간경화 환자에서 Non-O1 Vibrio cholerae에 의한 고름근육염 1예

Pyomyositis Caused by Non-O1 Vibrio Cholerae in a Patient with Liver Cirrhosis

  • 박성근 (가천의과학대학교 길병원 내과) ;
  • 이지원 (가천의과학대학교 길병원 내과) ;
  • 김진용 (가천의과학대학교 길병원 내과) ;
  • 박윤수 (가천의과학대학교 길병원 내과) ;
  • 서일혜 (가천의과학대학교 길병원 진단검사의학과) ;
  • 조용균 (가천의과학대학교 길병원 내과)
  • Park, Sung-Keun (Department of Internal Medicine, Gil Hospital, Gachon University of Medicine and Science) ;
  • Lee, Ji-Won (Department of Internal Medicine, Gil Hospital, Gachon University of Medicine and Science) ;
  • Kim, Jin-Yong (Department of Internal Medicine, Gil Hospital, Gachon University of Medicine and Science) ;
  • Park, Yoon-Soo (Department of Internal Medicine, Gil Hospital, Gachon University of Medicine and Science) ;
  • Seo, Yiel-Hae (Department of Laboratory Medicine, Gil Hospital, Gachon University of Medicine and Science) ;
  • Cho, Yong-Kyun (Department of Internal Medicine, Gil Hospital, Gachon University of Medicine and Science)
  • 발행 : 2011.03.01

초록

본 증례는 간경화 환자에서 non-O1 V. cholerae에 의한 고름근육염이 발생한 국내 첫 예이다. 이러한 기저 질환이 있는 환자에서 고름근육염의 원인균으로 non-O1 V. cholerae도 고려하여야 한다.

A 63-year-old man with underlying liver cirrhosis was admitted with painful swelling of the right thigh. We identified a non-O1 Vibrio cholerae strain in blood cultures and multiple pyomyositis in the lower limbs. Non-O1 V. cholerae strains have caused several well-studied food-borne outbreaks of gastroenteritis and have been responsible for sporadic cases of otitis media, skin and soft tissue infection, and bacteremia. Skin and soft tissue infection due to non-O1 V. cholerae is rare and is commonly associated with the presence of chronic underlying disease, such as liver cirrhosis, diabetes mellitus, an immunocompromised state, or a hematological malignancy. We report the first case of pyomyositis caused by non-O1 V. cholerae in Korea. Physicians should consider non-O1 V. cholerae strains as a pathogen that can cause pyomyositis.

키워드

참고문헌

  1. Levin MJ, Gardner P, Waldvogel FA. An unusual infection due to staphylococcus aureus. N Engl J Med 1971;284:196-198. https://doi.org/10.1056/NEJM197101282840407
  2. Bickels J, Ben-Sira L, Kessler A, Wientroub S. Primary pyomyositis. J Bone Joint Surg Am 2002;84:2277-2286.
  3. Christin L, Sarosi GA. Pyomyositis in North America: case reports and review. Clin Infect Dis 1992;15:668-677.
  4. Harbarth SJ, Lew DP. Pyomyositis as a nontropical disease. Curr Clin Top Infect Dis 1997;17:37-50.
  5. Couzigou C, Lacombe K, Girard PM, Vittecoq D, Meynard JL. Non-O:1 and non-O:139 Vibrio cholerae septicemia and pyomyositis in an immunodeficient traveler returning from Tunisia. Travel Med Infect Dis 2007;5:44-46. https://doi.org/10.1016/j.tmaid.2006.06.002
  6. Thompson FL, Iida T, Swings J. Biodiversity of vibrios. Microbiol Mol Biol Rev 2004;68:403-431. https://doi.org/10.1128/MMBR.68.3.403-431.2004
  7. Blake PA, Merson MH, Weaver RE, Hollis DG, Heublein PC. Disease caused by a marine vibrio: clinical characteristics and epidemiology. N Engl J Med 1979;300:1-5. https://doi.org/10.1056/NEJM197901043000101
  8. Sack DA, Sack RB, Nair GB, Siddique AK. Cholera. Lancet 2004;363:223-233. https://doi.org/10.1016/S0140-6736(03)15328-7
  9. Suankratay C, Phantumchinda K, Tachawiboonsak W, Wilde H. Non-serogroup O:1 Vibrio cholerae bacteremia and cerebritis. Clin Infect Dis 2001;32:E117-E119. https://doi.org/10.1086/319596
  10. Ou TY, Liu JW, Leu HS. Independent prognostic factors for fatality in patients with invasive vibrio cholerae non-O1 infections. J Microbiol Immunol Infect 2003;36:117-122.
  11. Ko WC, Chuang YC, Huang GC, Hsu SY. Infections due to non-O1 vibrio cholerae in southern Taiwan: predominance in cirrhotic patients. Clin Infect Dis 1998;27:774-780. https://doi.org/10.1086/514947
  12. Aguinaga A, Portillo ME, Yuste JR, et al. Non-O1 vibrio cholerae inguinal skin and soft tissue infection with bullous skin lesions in a patient with a penis squamous cell carcinoma. Ann Clin Microbiol Antimicrob 2009;8:17. https://doi.org/10.1186/1476-0711-8-17
  13. Lin CJ, Chiu CT, Lin DY, Sheen IS, Lien JM. Non-O1 vibrio cholerae bacteremia in patients with cirrhosis: 5-yr experience from a single medical center. Am J Gastroenterol 1996;91:336-340.
  14. Choi SM, Lee DG, Kim MS, et al. Bacteremic cellulitis caused by non-O1, non-O139 vibrio cholerae in a patient following hematopoietic stem cell transplantation. Bone Marrow Transplant 2003;31:1181-1182. https://doi.org/10.1038/sj.bmt.1704044
  15. Uhm JS, Oh BS, Lee SH, et al. A case of skin and soft tissue infection caused by non-O1, non-O139 vibrio cholerae in a patient with liver cirrhosis. Infect Chemother 2005;37:104-106.
  16. Yang WI, Park SM, Kim YJ, et al. Necrotizing fasciitis and sepsis due to vibrio cholera in a patient with liver cirrhosis. Korean J Med 2008;74:S131-S134.
  17. Mandell GL, Bennett JE, Dolin R. Mandell, Douglas and Bennett's Principles and Practice of Infectious Disease. 7th ed. New York: Churchill Livingstone, 2005.