The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지

$HbA_{1c}$ for Diagnosis of Type 2 Diabetes in Korea

한국인 당뇨병의 진단을 위한 당화혈색소 측정의 유용성

  • Sung, Yeon-Ah (Department of Internal Medicine, Ewha Womans University School of Medicine)
  • 성연아 (이화여자대학교 의과대학 내과학교실)
  • Published : 2011.03.01
⟨ Previous Next ⟩

초록

Glycated hemoglobin ($HbA_{1c}$, A1C) is a widely used marker of chronic glycemia, reflecting average blood glucose levels over a 2- to 3-month period of time. Recently role of A1C in diagnosing diabetes has been extensively reviewed and International Expert Committee and American diabetes Association recommended the use of the A1C test to diagnose diabetes, with a threshold of ${\geq}$ 6.5%. The diagnostic A1C cut point of 6.5% is associated with an inflection point for retinopathy prevalence, as are the diagnostic thresholds for plasma glucose levels. But A1C levels vary with different races. Meta-analyses for previous studies regarding A1C cut off value for plasma glucose in Koreans and determination of A1C cut point based on the development of diabetic microvascular complications in community based cohorts should be performed to establish diagnostic A1C cut point in Korean population.

키워드

참고문헌

  1. International Expert Committee. International Expert Committee Report on the Role of the A1C Assay in the Diagnosis of Diabetes. Diabetes Care 2009;32:1327-1334. https://doi.org/10.2337/dc09-9033
  2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010;33(Suppl 1):562-569.
  3. Nakagami T, Tominaga M, Nishimura R, et al. Is the measurement of glycated hemoglobin A1c alone an efficient screening test for undiagnosed diabetes? Japan National Diabetes Survey. Diabetes Res Clin Pract 2007;76:251-256. https://doi.org/10.1016/j.diabres.2006.09.015
  4. Kim KS, Kim SK, Lee YK, Park SW, Cho YW. Diagnostic value of glycated haemoglobin HbA(1c) for the early detection of diabetes in high-risk subjects. Diabet Med 2008;25:997-1000. https://doi.org/10.1111/j.1464-5491.2008.02489.x
  5. Kim SY, Park JH, Kang SM, Jin HY, Baek HS, Park TS. Value of HbA1c for diabetic screening in subject with normal fasting glucose. Korean Diabetes J 2008;32(Suppl 2):S218.
  6. Ku YH, Yoo SH, Jung HS, et al. Diagnostic value of HbA1c different clinical setting with different prevalence of diabetes mellitus. Korean Diabetes J 2008;32(Suppl 8):S311.
  7. Bae JC, Rhee EJ, Choi ES, et al. The cutoff value of HbA1c in predicting diabetes in Korean adults in a University Hospital in Seoul. Korean Diabetes J 2009;33:503-510. https://doi.org/10.4093/kdj.2009.33.6.503
  8. Saudek CD, Herman WH, Sacks DB, Bergenstal RM, Edelman D, Davidson MB. A new look at screening and diagnosing diabetes mellitus. J Clin Endocrinol Metab 2008;93:2447-2453. https://doi.org/10.1210/jc.2007-2174