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A Case of Left Atrial Metastasis From Hepatocellular Carcinoma: Life-Saving Palliative Resection Using Cardiopulmonary Bypass

  • Seo, Jae-Bin (Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center/Seoul National University College of Medicine) ;
  • Kim, Jun-Sung (Department of Thoracic and Cardiovascular Surgery, Seoul National University Boramae Medical Center/Seoul National University College of Medicine) ;
  • Jeong, Dong-Seop (Department of Thoracic and Cardiovascular Surgery, Seoul National University Boramae Medical Center/Seoul National University College of Medicine) ;
  • Chung, Woo-Young (Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center/Seoul National University College of Medicine) ;
  • Kim, Sang-Hyun (Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center/Seoul National University College of Medicine) ;
  • Kim, Myoung-A. (Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center/Seoul National University College of Medicine) ;
  • Zo, Joo-Hee (Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center/Seoul National University College of Medicine)
  • Published : 2011.09.30

Abstract

Hepatocellular carcinoma (HCC) with metastasis to the heart is uncommon. We report a rare case of left atrial metastasis of HCC which was resected palliatively as a live-saving procedure with the use of cardiopulmonary bypass. Despite chemoembolization, which was undertaken 11 times, cardiac metastasis occurred. Moreover, the right and left atria and left ventricle were involved simultaneously. The severe dyspnea improved dramatically after surgery. Following this, the patient underwent systemic chemotherapy and lived a life without recurrence of symptoms associated with mitral valve obstruction.

Keywords

References

  1. McManus B, Lee CH. Primary tumors of the heart. In: Libby P, Bonow RO, Mann DL, Zipes DP, editors. Braundwald's Heart Disease: a Textbook of Cardiovascular Medicine. 8th ed. Philadelphia: W.B. Saunders;2007. p.1815-28.
  2. Kew MC. Hepatic tumors and cysts. In: Feldman M, Friedman LS, Brandt LJ, editors. Sleisenger & Fordtran's Gastrointestinal and Liver Disease. 8th ed. Philadelphia: W.B. Saunders;2006. p.2007-33.
  3. Martinez Baca-Lopez F, Ramirez-Arias E, Rayas-Gomez AL, Bernal-Ruiz EA, Saturno-Chiu G. Hepatocellular carcinoma with invasion into right cardiac cavities: report of a case and literature review. J Am Soc Echocardiogr 2004;17:192-4. https://doi.org/10.1016/j.echo.2003.10.007
  4. Uemura M, Sasaki Y, Yamada T, et al. Surgery hepatocellular carcinoma with tumor thrombus extending into the right atrium: report of a successful resection without the use of cardiopulmonary bypass. Hepatogastroenterology 2004;51:1259-62.
  5. Mansour Z, Gerelli S, Kindo MJ, Billaud PJ, Eisenmann B, Mazzucotelli JP. Right atrial metastasis from hepatocellular carcinoma. J Card Surg 2007;22:231-3. https://doi.org/10.1111/j.1540-8191.2007.00397.x
  6. Abraham KP, Reddy V, Gattuso P. Neoplasms metastatic to the heart: review of 3314 consecutive autopsies. Am J Cardiovasc Pathol 1990;3:195-8.
  7. Masci G, Magagnoli M, Grimaldi A, et al. Metastasis of hepatocellular carcinoma to the heart: a case report and review of the literature. Tumori 2004;90:345-7.
  8. Ayoola EA, Olubuyide IO, Thomas J. Cardiovascular systemic invasion by hepatocellular carcinoma: incidence and pattern in a west African population. Afr J Med Med Sci 1994;23:61-6.
  9. Kojiro M, Nakahara H, Sugihara S, Murakami T, Nakashima T, Kawasaki H. Hepatocellular carcinoma with intra-atrial tumor growth: a clinicopathologic study of 18 autopsy cases. Arch Pathol Lab Med 1984;108:989-92.
  10. Lei MH, Ko YL, Kuan P, Lien WP, Chen DS. Metastasis of hepatocellular carcinoma to the heart: unusual patterns in three cases with antemortem diagnosis. J Formos Med Assoc 1992;91:457-61.
  11. Barasch E, Frazier OH, Silberman H, Shannon RL, Wilansky S. Left atrial metastasis from hepatocellular carcinoma: a case report. J Am Soc Echocardiogr 1994;7:547-9. https://doi.org/10.1016/S0894-7317(14)80015-1
  12. Ryu KH, Zang DY, Park SS, et al. Intracavitary cardiac metastasis in primary hepatoma. Korean Circ J 1993;23:123-8. https://doi.org/10.4070/kcj.1993.23.1.123
  13. Salcedo EE, Cohen GI, White RD, Davison MB. Cardiac tumors: diagnosis and management. Curr Probl Cardiol 1992;17:73-137.
  14. Matsumura M, Takamoto S, Kyo S, Yokote Y, Omoto R. Advantages of transesophageal color Doppler echocardiography in the diagnosis and surgical treatment of cardiac masses. J Cardiol 1990;20:701-14.
  15. Ekmektzoglou KA, Samelis GF, Xanthos T. Heart and tumors: location, metastasis, clinical manifestations, diagnostic approaches and therapeutic considerations. J Cardiovasc Med (Hagerstown) 2008;9:769-77. https://doi.org/10.2459/JCM.0b013e3282f88e49
  16. Godwin JD, Axel L, Adams JR, Schiller NB, Simpson PC Jr, Gertz EW. Computed tomography: a new method for diagnosing tumor of the heart. Circulation 1981;63:448-51. https://doi.org/10.1161/01.CIR.63.2.448
  17. Lee KS, Lee HH, Youn TJ, Nam GB, Kim DW, Cho MC. Resection of cardiac metastasis of malignant melanoma. Korean Circ J 2000;30:1170-4. https://doi.org/10.4070/kcj.2000.30.9.1170
  18. Lin YS, Jung SM, Tsai FC, et al. Hepatoma with cardiac metastasis: an advanced cancer requiring advanced treatment. World J Gastroenterol 2007;13:3513-6. https://doi.org/10.3748/wjg.v13.i25.3513
  19. Kotani E, Kiuchi K, Takayama M, et al. Effectiveness of transcoronary chemoembolization for metastatic right ventricular tumor derived from hepatocellular carcinoma. Chest 2000;117:287-9. https://doi.org/10.1378/chest.117.1.287
  20. Dazai Y, Katoh T, Katoh I, Sueda S, Yoshida R. Effectiveness of chemoembolization therapy for metastatic right atrial tumor thrombus associated with hepatocellular carcinoma. Chest 1989;96:434-6. https://doi.org/10.1378/chest.96.2.434