Korean Circulation Journal

  • 제41권9호
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  • Pages.535-541
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  • 2011
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Effects of Ramiprilat-Coated Stents on Neointimal Hyperplasia, Inflammation, and Arterial Healing in a Porcine Coronary Restenosis Model

  • Hong, Young-Joon (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Jeong, Myung-Ho (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Song, Sun-Jung (Center for Functional Nano Fine Chemicals & School of Applied Chemical Engineering, Chonnam National University) ;
  • Sim, Doo-Sun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kim, Jung-Ha (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Lim, Kyung-Seob (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Hachinohe, Daisuke (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Ahmed, Khurshid (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Hwang, Seung-Hwan (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Lee, Min-Goo (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Ko, Jum-Suk (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Park, Keun-Ho (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Yoon, Hyun-Ju (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Yoon, Nam-Sik (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kim, Kye-Hun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Park, Hyung-Wook (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kim, Ju-Han (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Ahn, Young-Keun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Cho, Jeong-Gwan (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Cho, Dong-Lyun (Center for Functional Nano Fine Chemicals & School of Applied Chemical Engineering, Chonnam National University) ;
  • Park, Jong-Chun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kang, Jung-Chaee (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences)
  • 발행 : 2011.09.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: The renin-angiotensin-aldosterone system has been implicated in the pathogenesis of neointimal hyperplasia, and a role for angiotensin II in the migration and proliferation of vascular smooth muscle cells in restenotic lesions has been proposed. The aim of this study was to determine the anti-proliferative and anti-inflammatory effects of ramiprilat-coated stents in a porcine coronary overstretch restenosis model. Subjects and Methods: Pigs were randomized into two groups in which the coronary arteries {16 pigs (16 coronaries in each group)} had a 3.0${\times}$17 mm ramiprilat-coated MAC stent or a 3.0${\times}$17 mm control MAC stent (AMG, Munich, Germany) implanted with oversizing (stent-to-artery ratio, 1.3 : 1) in porcine coronary arteries, and histopathologic analysis was assessed 28 days after stenting. Results: There were no significant differences in the injury and inflammation scores between the two groups (1.20${\pm}$0.43 vs. 1.23${\pm}$0.57, p=0.8; and 1.21${\pm}$0.39 vs. 1.25${\pm}$0.49, p=0.6, respectively). Within the neointima, most inflammatory cells were lymphohistiocytes. Significant positive correlations existed between inflammatory cell counts and the neointima areas (r=0.567, p<0.001), and between inflammatory cell counts and the percent area stenosis (r=0.478, p<0.001). There was no significant difference in the inflammatory cell counts normalized to the injury (110${\pm}$89 vs. 123${\pm}$83, p=0.4) and fibrin scores (0.15${\pm}$0.06 vs. 0.17${\pm}$0.07, p= 0.8) between the 2 groups. There were trends toward a smaller neointima area (1.06${\pm}$0.51 $mm^{2}$ vs. 1.28${\pm}$0.35 $mm^{2}$, p=0.083) and a smaller percent area stenosis (18.9${\pm}$8.7% vs. 21.8${\pm}$7.2%, p=0.088) in the ramiprilat-coated stent group. Conclusion: Although the ramiprilat-coated stent did not show significant inhibitory effects on neointimal hyperplasia, the ramiprilat-coated stent showed good effects on the inflammatory reaction and arterial healing similar to the control stent in a porcine coronary restenosis model.

키워드

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