The Korean Journal of Medicine

  • 제80권1호
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  • Pages.20-30
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  • 2011
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지

안지오텐신 전환효소 억제제/안지오텐신 수용체 차단제 사용과 고칼륨혈증

Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: A Closer Look at Hyperkalemia

  • 정성진 (가톨릭대학교 의과대학 내과학교실) ;
  • 박철휘 (가톨릭대학교 의과대학 내과학교실)
  • Chung, Sung-Jin (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Park, Cheol-Whee (Department of Internal Medicine, The Catholic University of Korea College of Medicine)
  • 발행 : 2011.01.01
⟨ 이전 논문 다음 논문 ⟩

초록

Therapeutic manipulation of the renin-angiotensin-aldosterone system (RAAS) is an important strategy for improving hypertension, diabetes, cardiovascular disease, and chronic kidney disease. Development of hyperkalemia after the administration of RAAS inhibitors is of particular concern because patients at highest risk for this complication are often the same patients who derive the greatest cardiovascular or renoprotective benefit. Based on an overview of the incidence of hyperkalemia during treatment with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers alone and in combination, this review suggests approaches for monitoring, detecting, and managing hyperkalemia in patients treated with RAAS inhibitors. Although the incidence of hyperkalemia with RAAS inhibitors is generally low, hyperkalemia can be associated with increased mortality. When using RAAS inhibitors, it is important to monitor on-treatment electrolyte levels and renal function parameters in patients with a high risk for hyperkalemia.

키워드

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