The Korean Journal of Medicine

  • 제80권1호
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  • Pages.113-117
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  • 2011
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지

비소세포 폐암의 신생물딸림증후군으로 발생한 호산구증가증 1예

A Case of Eosinophilia as a Manifestation of Paraneoplastic Syndrome in Non-Small-Cell Lung Cancer

  • 김희정 (강원대학교 의과대학 내과학교실) ;
  • 정대준 (강원대학교 의과대학 내과학교실) ;
  • 이희영 (강원대학교 의과대학 내과학교실) ;
  • 황인규 (중앙대학교 의과대학 내과학교실) ;
  • 송서영 (강원대학교 의과대학 내과학교실)
  • Kim, Hee-Jung (Department of Internal Medicine, Kangwon National University College of Medicine) ;
  • Jeong, Dae-Joon (Department of Internal Medicine, Kangwon National University College of Medicine) ;
  • Lee, Hui-Young (Department of Internal Medicine, Kangwon National University College of Medicine) ;
  • Hwang, In-Gyu (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Song, Seo-Young (Department of Internal Medicine, Kangwon National University College of Medicine)
  • 발행 : 2011.01.01
⟨ 이전 논문 다음 논문 ⟩

초록

저자들은 말초혈액 호산구 증가증이 동반된 73세 여자 환자에서 불량한 예후를 보인 비소세포성 폐암 1예를 경험하였고, 이에 대한 국내의 보고가 없어 문헌고찰과 함께 보고하는 바이다.

Eosinophilia is most frequently associated with asthma, allergic conditions, and parasitic infestation. Eosinophilia can also be associated with many forms of cancer. However, eosinophilia is infrequently associated with solid tumors. We experienced a 73-year-old-woman with eosinophilia as a manifestation of paraneoplastic syndrome that was combined with non-small-cell lung cancer (NSCLC). Initially, she was diagnosed with idiopathic hypereosinophilic syndrome, but was diagnosed with NSCLC 1 month later. Here, we report this case with a brief review of the literature.

키워드

참고문헌

  1. Lo Re V 3rd, Fox KR, Ferrari VA, Scott CH, Kossev PM, Kostman JR. Hypereosinophilia associated with cardiac rhabdomyosarcoma. Am J Hematol 2003;74:64-67. https://doi.org/10.1002/ajh.10373
  2. Devita VT, Samuel H, Rosenberg SA. Cancer Principles and Practice of Oncology. 7th ed. Philadelphia: Lippincott Williams & Wilkins, 2005:2194.
  3. Haskell CM, Berek JS. Cancer Treatment. 5th ed. Philadelphia: W.B. Saunders Company, 2001:249.
  4. Matsumoto S, Tamai T, Yanagisawa K, Kawamura S, Fujita S. Lung cancer with eosinophilia in the peripheral blood and the pleural fluid. Intern Med 1992;31:525-529. https://doi.org/10.2169/internalmedicine.31.525
  5. Reddy SS, Hyland RH, Alison RE, Sturgeon JF, Hutcheon MA. Tumor-associated peripheral eosinophilia: two unusual cases. J Clin Oncol 1984;2:1165-1169. https://doi.org/10.1200/JCO.1984.2.10.1165
  6. Yuen BH, Reyes CV, Rawal PA, Sosman J, Jensen J. Severe eosinophilia and hepatocellular carcinoma: an unusual association. Diagn Cytopathol 1995;13:151-154. https://doi.org/10.1002/dc.2840130215
  7. Hirata J, Koga T, Nishimura J, Ibayashi H. Pancreatic carcinoma associated with marked eosinophilia: a case report. Eur J Haematol 1987;39:462-466.
  8. Pandit R, Scholnik A, Wulfekuhler L, Dimitrov N. Non-small-cell cancer associated with excessive eosinophilia and secretion of interleukin- 5 as a paraneoplastic syndrome. Am J Hematol 2007;82: 234-237. https://doi.org/10.1002/ajh.20789
  9. Kodama T, Takada K, Kameya T, Shimosato Y, Tsuchiya R, Okabe T. Large cell carcinoma of the lung associated with marked eosinophilia: a case report. Cancer 1984;54:2313-2317. https://doi.org/10.1002/1097-0142(19841115)54:10<2313::AID-CNCR2820541044>3.0.CO;2-I
  10. EI-Osta H, EI Haddad P, Nabbout N. Lung carcinoma associated with excessive eosinophilia. J Clin Oncol 2008;26:3456-3457. https://doi.org/10.1200/JCO.2007.15.8899
  11. Weller PF. The immunobiology of eosinophils. N Engl J Med 1991;324:1110-1118. https://doi.org/10.1056/NEJM199104183241607
  12. Chung JP, Nam DK, Lee SJ, Lee EK, Hahn JS, Ko YW. A clinical study on eosinophilia: with a report of 5 cases of hypereosinophilic syndrome. Korean J Hematol 1988;23:127-137.
  13. Lowe D, Jorizzo J, Hutt MS. Tumor-associated eosinophilia: a review. J Clin Pathol 1981;34:1343-1348. https://doi.org/10.1136/jcp.34.12.1343
  14. Sul HR, Kim SJ, Kim DI, et al. Peripheral blood eosinophilia: an unusual presentation of bone marrow involvement in a patient with relapsed thyroid papillary carcinoma. Korean J Hematol 2005;40:274-277. https://doi.org/10.5045/kjh.2005.40.4.274
  15. Lee NR, Jeon SM, Cha BH, Park KH, Lee JS, Moon DH. A case of paraneoplastic peripheral eosinophilia associated with a sigmoid colon cancer. Korean J Med 2005;69:S753-S757.
  16. Dellon AL, Hume RB, Chretien PB. Eosinophilia in bronchogenic carcinoma. N Engl J Med 1974;291:207-208.
  17. Ghossein NA, Stacey P. The prognostic significance of radiation- related eosinophilia: a preliminary report. Radiology 1973; 107:631-633. https://doi.org/10.1148/107.3.631