Fisheries and Aquatic Sciences

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Anti-hyperlipidemia and Anti-arteriosclerosis Effects of Laminaria japonica in Sprague-Dawley Rats

  • Lee, Seung-Joo (Dept. of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Kim, Chong-Wook (Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Jang, Hyuk-Jai (Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Cho, Soon-Yeong (Dept. of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Choi, Jong-Won (College of Pharmacy, Kyungsung University)
  • Received : 2011.08.01
  • Accepted : 2011.11.10
  • Published : 2011.12.31
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Abstract

The anti-hyperlipidemic effects of dietary supplementation with sea tangle Laminaria japonica were investigated using an animal model in which normal rats were fed either sea tangle, sea tangle ethanol extract (EE-ST) and sea tangle extracted residue (ER-ST). Total lipid and triglyceride levels in the serum were significantly (P < 0.05) reduced in rats fed ER-ST at a dose of 200 mg/kg body weight when compared to hyperlipidemic control rats. Significant decreases in serum total cholesterol and low density lipoprotein-cholesterol levels also occurred in rats fed ER-ST at 200 mg/kg body weight. In addition, the atherosclerosis index and superoxide dismutase in blood lipids were significantly (P < 0.05) lowered in rats fed ER-ST at 200 mg/kg body weight as compared to control rats. In conclusion, sea tangle and ER-ST exhibited beneficial anti-hyperlipidemic and anti-arteriosclerosis effects.

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References

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