The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Therapeutic Effect of the Impatiens balsamina Linne Extract on the Membranous Nephropathy

봉선화(鳳仙花) 추출물의 막성신증(膜性腎症)에 대한 치료효과(治療效果)

  • Wi, Gyeong (Department of Herbal Pharmaceutical Science, Joongbu University) ;
  • Yoo, Ji-Hyun (International Ginseng and Herb Research Institute Geumsan) ;
  • Doh, Eun-Soo (Department of Herbal Pharmaceutical Science, Joongbu University) ;
  • Chang, Jun-Pok (Department of Herbal Pharmaceutical Science, Joongbu University) ;
  • Kil, Ki-Jung (Department of Herbal Pharmaceutical Science, Joongbu University)
  • 위경 (중부대학교 한방제약과학과) ;
  • 유지현 ((재)금산국제인삼약초연구소) ;
  • 도은수 (중부대학교 한방제약과학과) ;
  • 장준복 (중부대학교 한방제약과학과) ;
  • 길기정 (중부대학교 한방제약과학과)
  • Received : 2011.11.09
  • Accepted : 2011.12.16
  • Published : 2011.12.30
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Abstract

Objective : Membranous nephropathy(MN) is one of the most common causes of nephrotic syndrome in adults. MN has been defined as granular subepithelial deposition of IgG immune complexes along the glomerular basement membrane(GBM). However, there is not a satisfactory treatment for MN. We aimed to identify the effect of Impatiens balsamina Linne(IBL) treatment on cationic bovine serum albumin(cBSA)-induced MN in a mouse model. Methods : Mice were divided into 4 groups. The normal group was injected with saline. The Control group was treated with cBSA(50 mg/kg i.p) only. The third group IBL-100, was treated with cBSA(50 mg/kg, i.p) and IBL(100 mg/kg, p.o). The fourth group IBL-400, was treated with cBSA(50 mg/kg, i.p) and IBL (400 mg/kg, p.o). After cBSA and IBL treatment for 6 weeks, we measured change of body weight, proteinuria, serum albumin, total cholesterol, triglyceride, BUN, creatinine, IgA, IgM, IgG, TNF-${\alpha}$, IL-6 and IL-$1{\beta}$ levels. The morphologic changes of renal glomeruli were also observed with a light microscope. Results : The level of proteinuria significantly decreased and serum albumin increased in groups treated with cBSA and IBL extract compared with the control. The levels of serum triglyceride, BUN, IgG, TNF-${\alpha}$, IL-$1{\beta}$ significantly decreased in both IBL groups. In histological findings of kidney tissue, thickening of GBM decreased in both IBL groups. Conclusions : This study shows that IBL might be effective for treatment of acute stage MN. More clinical data and studies are to be done for efficient application.

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References

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