Journal of Cardiovascular Imaging

Korean Society of Echocardiography (한국심초음파학회)
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REVERSIBLE SYMPTOMATIC MYOCARDITIS INDUCED BY ALL-TRANS RETINOIC ACID ADMINISTRATION DURING INDUCTION TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA: RARE CARDIAC MANIFESTATION AS A RETINOIC ACID SYNDROME

  • Choi, Seong-Hoon (Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Hyeong-Su (Division of Cardiology, Department of Hemato-Oncology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Jung, Chang-Soo (Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Jung, Seong-Woong (Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Lee, Yun-Ja (Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Rheu, Jin-Kyeong (Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Jo, Jung-Rae (Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Lee, Nam-Ho (Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
  • Published : 2011.06.27
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Abstract

Treatment by All-trans retinoic acid (ATRA) followed by anthracycline-AraC chemotherapy has improved the outcome of acute promyelocytic leukemia. ATRA is usually well tolerated, but a few major side effects can be observed. Retinoic acid syndrome (RAS) often occurs during the induction chemotherapy of acute promyelocytic leukemia. A pericardial effusion is a common cardiac manifestation but myocarditis has been rarely documented. Here we reports a very rare case of fully recovered myocarditis as a result of RAS related to ATRA administration during induction treatment of acute promyelocytic leukemia which documented by echocardiographic evidence.

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References

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  1. Ivosidenib induction therapy complicated by myopericarditis and cardiogenic shock: A case report and literature review vol.26, pp.3, 2011, https://doi.org/10.1177/1078155219865934