Pulmonary Lipiodol Accumulation after Transarterial Chemoembolization: CT Findings and Its Radiologic Outcomes

경도관동맥화학색전술 후 발생한 폐 리피오돌 침착: CT 소견과 영상의학적 예후

  • Youn, In-Young (Department of Radiology, Chung-Ang University Medical Center, Chung-Ang University College of Medicine) ;
  • Chong, Se-Min (Department of Radiology, Chung-Ang University Medical Center, Chung-Ang University College of Medicine) ;
  • Kwak, Byung-Kook (Department of Radiology, Chung-Ang University Medical Center, Chung-Ang University College of Medicine) ;
  • Shim, Hyung-Jin (Department of Radiology, Chung-Ang University Medical Center, Chung-Ang University College of Medicine) ;
  • Seo, Gi-Young (Department of Radiology, Chung-Ang University Medical Center, Chung-Ang University College of Medicine) ;
  • Seo, Jae-Seung (Department of Radiology, Chung-Ang University Medical Center, Chung-Ang University College of Medicine) ;
  • Kim, Jae-Kyun (Department of Radiology, Chung-Ang University Medical Center, Chung-Ang University College of Medicine)
  • 윤인영 (중앙대학교 의과대학 중앙대학교병원 영상의학과학교실) ;
  • 정세민 (중앙대학교 의과대학 중앙대학교병원 영상의학과학교실) ;
  • 곽병국 (중앙대학교 의과대학 중앙대학교병원 영상의학과학교실) ;
  • 심형진 (중앙대학교 의과대학 중앙대학교병원 영상의학과학교실) ;
  • 서기영 (중앙대학교 의과대학 중앙대학교병원 영상의학과학교실) ;
  • 서재승 (중앙대학교 의과대학 중앙대학교병원 영상의학과학교실) ;
  • 김재균 (중앙대학교 의과대학 중앙대학교병원 영상의학과학교실)
  • Published : 2011.12.01

Abstract

Purpose: To evaluate CT findings and radiologic outcomes of pulmonary lipiodol accumulation (PLA) after transarterial chemoembolization (TACE). Materials and Methods: This retrospective study involved 488 TACEs for hepatocellular carcinoma (HCC) (n = 160) and hepatic metastasis for non-hepatic malignancies (n = 7) in 167 patients. We reviewed the patient clinicoradiologic findings before and after TACE and calculated the incidence of PLA and PLA resolution time after initial CT and after TACE. Results: Lipiodol accumulation in the lungs was seen under CT after TACE in seven patients (M : F = 6 : 1, mean age 61 years). The incidence of PLA at CT was 4.1% (7/167 patients). In five patients, associated intrathoracic abnormalities including pleural effusion with (n = 3) or without consolidation (n = 2) were revealed at CT scans. The CT resolution time and PLA recovery time were 56 ${\pm}$ 54 days and 66 ${\pm}$ 52 days, respectively. Conclusion: The recovery time for lipiodol accumulation was 66 days. It is believed that the clinical and radiologic outcome of PLA without respiratory failure is promising, and conservative treatment will suffice when lipiodol accumulation in the lungs is seen in CT images after TACE.

목적: 경도관동맥화학색전술 후 발생한 폐 리피오돌 침착의 CT 소견과 영상의학적 예후를 평가하는 것이었다. 대상과 방법: 간세포암(n = 160)과 간 외 악성질환의 간 전이(n = 7) 치료를 위해 167명의 환자에서 시행된 전체 488건의 경도관동맥화학색전술을 대상으로 후향적으로 시행되었다. 경도관동맥화학색전술 전후의 임상적 영상의학적 소견을 검토하였고, 시술 전후의 CT를 이용하여 폐 리피오돌 침착의 발생률과 회복 시간을 계산하였다. 결과: 경도관동맥화학색전술 후 CT에서 폐의 리피오돌 침착은 7명의 환자에서 관찰되었고(M : F = 6 : 1, mean 61 years), CT에서 폐 리피오돌 침착의 발생률은 4.1%였다(7/167 patients). 그 중 5명이 CT에서 흉막삼출액(n = 2) 또는 폐경화와 흉막삼출액(n = 3)의 흉강 내 이상을 동반하였다. PLA의 CT 소실 시간과 회복 시간은 각각 56 ${\pm}$ 54일, 66 ${\pm}$ 52일이었다. 결론: 폐 리피오돌 침착의 평균 회복 시간은 66일이었다. 시술 후 CT에서 폐 리피오돌 침착이 관찰된다 하더라도 호흡부전 증상을 동반하지 않는다면 임상적, 영상의학적 예후는 긍정적이며, 보존적 치료만으로도 충분할 것으로 생각된다.

Keywords

References

  1. Xia J, Ren Z, Ye S, Sharma D, Lin Z, Gan Y, et al. Study of severe and rare complications of transarterial chemoembolization (TACE) for liver cancer. Eur J Radiol 2006;59:407-412 https://doi.org/10.1016/j.ejrad.2006.03.002
  2. Lee KH, Sung KB, Lee DY, Park SJ, Kim KW, Yu JS. Transcatheter arterial chemoembolization for hepatocellular carcinoma: anatomic and hemodynamic considerations in the hepatic artery and portal vein. Radiographics 2002;22:1077-1091
  3. Chung JW, Park JH, Im JG, Han JK, Han MC. Pulmonary oil embolism after transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 1993;187:689-693
  4. Tajima T, Honda H, Kuroiwa T, Yabuuchi H, Okafuji T, Yosimitsu K, et al. Pulmonary complications after hepatic artery chemoembolization or infusion via the inferior phrenic artery for primary liver cancer. J Vasc Interv Radiol 2002;13: 893-900 https://doi.org/10.1016/S1051-0443(07)61772-2
  5. Choi SY, Goo JM, Chun HJ, Han DH. Lipiodol can simulate cement embolism in patients having undergone vertebroplasty due to metastasis from hepatocellular carcinoma. AJNR Am J Neuroradiol 2010;31:E2-E3 https://doi.org/10.3174/ajnr.A1886
  6. Wu GC, Perng WC, Chen CW, Chian CF, Peng CK, Su WL. Acute respiratory distress syndrome after transcatheter arterial chemoembolization of hepatocellular carcinomas. Am J Med Sci 2009;338:357-360 https://doi.org/10.1097/MAJ.0b013e3181b15625
  7. Raoul JL, Bourguet P, Bretagne JF, Duvauferrier R, Coornaert S, Darnault P, et al. Hepatic artery injection of I-131-labeled lipiodol. Part I. Biodistribution study results in patients with hepatocellular carcinoma and liver metastases. Radiology 1988;168:541-545
  8. Lin MT, Kuo PH. Pulmonary lipiodol embolism after transcatheter arterial chemoembolization for hepatocellular carcinoma. JRSM Short Rep 2010;1:6 https://doi.org/10.1258/shorts.2009.090352
  9. Fraimow W, Wallace S, Lewis P, Greening RR, Cathcart RT. Changes in pulmonary function due to lymphangiography. Radiology 1965;85:231-241
  10. Samejima M, Tamura S, Kodama T, Yuuki Y, Takasaki J, Sekiva R, et al. [Pulmonary complication following intra-arterial infusion of lipiodol-adriamycin emulsion for hepatocellular carcinoma, report of a case]. Nihon Igaku Hoshasen Gakkai Zasshi 1990;50:24-28
  11. Lorcher U, Peters J, Kollath J. [Changes in the lungs and pleura following chemoembolization of liver tumors with mitomycin-lipiodol]. Rofo 1990;152:569-573 https://doi.org/10.1055/s-2008-1046923
  12. Charnsangavej C, Chuang VP, Wallace S, Soo CS, Bowers T. Angiographic classification of hepatic arterial collaterals. Radiology 1982;144:485-494
  13. Koehler RE, Korobkin M, Lewis F. Arteriographic demonstration of collateral arterial supply to the liver after hepatic artery ligation. Radiology 1975;117:49-54
  14. Han D, Lee KS, Franquet T, Muller NL, Kim TS, Kim H, et al. Thrombotic and nonthrombotic pulmonary arterial embolism: spectrum of imaging findings. Radiographics 2003;23: 1521-1539 https://doi.org/10.1148/rg.1103035043
  15. Rossi SE, Goodman PC, Franquet T. Nonthrombotic pulmonary emboli. AJR Am J Roentgenol 2000;174:1499-1508 https://doi.org/10.2214/ajr.174.6.1741499