DOI QR코드

DOI QR Code

Successful Treatment of Stereotactic Body Radiation Therapy Combined with Transarterial Chemolipiodolization for Hepatocellular Carcinoma with Biliary Obstruction

  • Park, Chan-Kwon (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Bae, Si-Hyun (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Yang, Hong-Jun (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Chun, Ho-Jong (Department of Radiation Oncology, The Catholic University of Korea School of Medicine) ;
  • Choi, Il-Bong (Department of Radiation Oncology, The Catholic University of Korea School of Medicine) ;
  • Choi, Jong-Young (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Yoon, Seung-Kew (Department of Internal Medicine, The Catholic University of Korea School of Medicine)
  • 발행 : 2011.03.01

초록

Conventional radiation therapy (RT) is a widely recognized treatment for hepatocellular carcinoma (HCC). However, conventional RT plays only a limited role in HCC treatment because of its low efficacy and the low tolerance of the liver for this modality. Stereotactic body radiation therapy (SBRT) was recently developed and represents the most advanced radiation therapy technique currently available. It can deliver a high dose in a short time to well-defined hepatic tumors, with rapid dose fall-off gradients. We believe that SBRT with transarterial chemolipiodolization (TACL) may prove promising as a combined treatment modality for HCC due to its precision and relative safety. Here we present a case of successful treatment of advanced HCC with obstructive jaundice using this combined modality.

키워드

참고문헌

  1. Park HC, Seong J, Han KH, Chon CY, Moon YM, Suh CO. Doseresponse relationship in local radiotherapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2002;54:150-155.
  2. Herfarth KK, Debus J, Lohr F, et al. Stereotactic single-dose radiation therapy of liver tumors: results of a phase I/II trial. J Clin Oncol 2001;19:164-170. https://doi.org/10.1200/JCO.2001.19.1.164
  3. Kwon JH, Bae SH, Kim JY, et al. Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection. Stereotactic radiotherapy for liver cancer. BMC Cancer 2010;10:475-484. https://doi.org/10.1186/1471-2407-10-475
  4. Seong J, Keum KC, Han KH, et al. Combined transcatheter arterial chemoembolization and local radiotherapy of unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 1999;43:393-397. https://doi.org/10.1016/S0360-3016(98)00415-5
  5. Han KH, Kim JK. Liver cancer in Korea. Hepatol Res 2007;37 Suppl 2:S106-S109. https://doi.org/10.1111/j.1872-034X.2007.00171.x
  6. Lau WY, Leung KL, Leung TW, et al. Obstructive jaundice secondary to hepatocellular carcinoma. Surg Oncol 1995;4:303-308. https://doi.org/10.1016/S0960-7404(10)80042-8
  7. Mallory TB, Castleman B, Parris EE. Case records of the Massachusetts General Hospital Case. N Engl J Med 1947;237:673-678. https://doi.org/10.1056/NEJM194710302371805
  8. Lai EC, Lau WY. Hepatocellular carcinoma presenting with obstructive jaundice. ANZ J Surg 2006;76:631-636. https://doi.org/10.1111/j.1445-2197.2006.03794.x
  9. Lau W, Leung K, Leung TW, et al. A logical approach to hepatocellular carcinoma presenting with jaundice. Ann Surg 1997;225:281-285. https://doi.org/10.1097/00000658-199703000-00007
  10. Yamada K, Izaki K, Sugimoto K, et al. Prospective trial of combined transcatheter arterial chemoembolization and threedimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2003;57:113-119. https://doi.org/10.1016/S0360-3016(03)00434-6
  11. Seong J, Park HC, Han KH, et al. Clinical results of 3-dimensional conformal radiotherapy combined with transarterial chemoembolization for hepatocellular carcinoma in the cirrhotic patients. Hepatol Res 2003;27:30-35. https://doi.org/10.1016/S1386-6346(03)00162-1
  12. You CR, Jang JW, Kang SH, et al. Efficacy of transarterial chemolipiodolization with or without 3-dimensional conformal radiotherapy for huge HCC with portal vein tumor thrombosis. Korean J Hepatol 2007;13:378-386. https://doi.org/10.3350/kjhep.2007.13.3.378
  13. Lawrence TS, Ten Haken RK, Kessler ML, et al. The use of 3-D dose volume analysis to predict radiation hepatitis. Int J Radiat Oncol Biol Phys 1992;23:781-788. https://doi.org/10.1016/0360-3016(92)90651-W
  14. Blomgren H, Lax I, Goranson H, et al. Radiosurgery for tumors in the body: clinical experience using a new method. J Radiosurgery 1998;1:63-74. https://doi.org/10.1023/B:JORA.0000010880.40483.c4

피인용 문헌

  1. Transcatheter Arterial Chemoembolization: History for More than 30 Years vol.2012, pp.None, 2011, https://doi.org/10.5402/2012/480650
  2. A case report of hepatocellular carcinoma adjacent to hepatic biloma successfully treated by stereotactic body radiation therapy vol.57, pp.1, 2011, https://doi.org/10.2957/kanzo.57.17
  3. Carbon ion radiotherapy for patients with hepatocellular carcinoma in the caudate lobe vol.51, pp.3, 2011, https://doi.org/10.1111/hepr.13606