Neonatal Medicine

  • 제18권2호
  • /
  • Pages.383-386
  • /
  • 2011
  • /
  • 2287-9412(pISSN)
  • /
  • 2287-9803(eISSN)
대한신생아학회 (The Korean Society of Neonatology)
권호 표지
DOI QR코드

DOI QR Code

혈중 아연 농도가 정상인 모유수유를 한 미숙아에서 보인 장병성 선단 피부염 1례

A Case of Acrodermatitis Enteropathica with Normal Serum Zinc Level in a Breastfed Preterm Infant

  • 백정현 (고려대학교 의과대학 소아청소년과학교실) ;
  • 박철 (고려대학교 의과대학 소아청소년과학교실) ;
  • 박규희 (고려대학교 의과대학 소아청소년과학교실) ;
  • 이정화 (고려대학교 의과대학 소아청소년과학교실) ;
  • 홍영숙 (고려대학교 의과대학 소아청소년과학교실) ;
  • 이주원 (고려대학교 의과대학 소아청소년과학교실) ;
  • 백유상 (고려대학교 의과대학 피부과학교실) ;
  • 송해준 (고려대학교 의과대학 피부과학교실) ;
  • 이장훈 (아주대학교 의과대학 소아과학교실)
  • Baek, Jung-Hyun (Department of Pediatrics, College of Medicine, Korea University) ;
  • Park, Chul (Department of Pediatrics, College of Medicine, Korea University) ;
  • Park, Kyu-Hee (Department of Pediatrics, College of Medicine, Korea University) ;
  • Lee, Jung-Hwa (Department of Pediatrics, College of Medicine, Korea University) ;
  • Hong, Young-Sook (Department of Pediatrics, College of Medicine, Korea University) ;
  • Lee, Joo-Won (Department of Pediatrics, College of Medicine, Korea University) ;
  • Baek, Yoo-Sang (Department of Dermatology, College of Medicine, Korea University) ;
  • Song, Hae-Jun (Department of Dermatology, College of Medicine, Korea University) ;
  • Lee, Jang-Hoon (Department of Pediatrics, Ajou University School of Medicine)
  • 발행 : 2011.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

Acrodermatitis enteropathica due to zinc deficiency is characterized by periorificial dermatitis, alopecia, and intractable diarrhea. Here we report a case of transient acrodermatitis enteropathica in a 2-month-old preterm infant, whose skin is erythematous, scaly, eczematous, with an eruption starting from the periorificial area. While her serum zinc level was normal at 118.2 ug/dL, the serum alkaline phosphatase level was low at 48 IU/L and the serum alkaline phosphatase level get increased concordant with clinical improvement after zinc supplementation. Hence, this case shows that the diagnosis of zinc deficiency can be aided with a low level of serum alkaline phoaphatase although serum zinc level is normal.

키워드

참고문헌

  1. Aggett PJ. Acrodermatitis enteropathica. J Inherit Metab Dis 1983; 6 Suppl 1:39-43.
  2. Krebs NF, Hambidge KM. Zinc requirements and zinc intakes of breast-fed infants. Am J Clin Nutr 1986;43:288-92.
  3. Bilinski DL, Ehrenkranz RA, Cooley-Jacobs J, McGuire J. Symptomatic zinc deficiency in a breast-fed, premature infant. Arch Dermatol 1987;123:1221-4. https://doi.org/10.1001/archderm.1987.01660330132026
  4. Maverakis E, Fung MA, Lynch PJ, Draznin M, Michael DJ, Ruben B, et al. Acrodermatitis enteropathica and an overview of zinc metabolism. J Am Acad Dermatol 2007;56:116-24. https://doi.org/10.1016/j.jaad.2006.08.015
  5. Krieger I, Evans GW. Acrodermatitis enteropathica without hypozincemia: therapeutic effect of a pancreatic enzyme preparation due to a zinc-binding ligand. J Pediatr 1980;96:32-5. https://doi.org/10.1016/S0022-3476(80)80319-2
  6. Weismann K, Hoyer H. Serum alkaline phosphatase and serum zinc levels in the diagnosis and exclusion of zinc deficiency in man. Am J Clin Nutr 1985;41:1214-9.
  7. Obladen M, Loui A, Kampmann W, Renz H. Zinc deficiency in rapidly growing preterm infants. Acta Paediatr 1998;87:685-91. https://doi.org/10.1111/j.1651-2227.1998.tb01531.x
  8. Coelho S, Fernandes B, Rodrigues F, Reis JP, Moreno A, Figueiredo A. Transient zinc deficiency in a breast fed, premature infant. Eur J Dermatol 2006;16:193-5.
  9. Pi SW. Manual of Neonatal Care. 2nd ed. Seoul: The Korean Socitey of Neonatology, 2008:114.
  10. Krebs NF, Westcott J. Zinc and breastfed infants: if and when is there a risk of deficiency? Adv Exp Med Biol 2002;503:69-75.
  11. Mandato F, Rubegni P, Buonocore G, Fimiani M. A case of transient zinc deficiency in a breast-fed preterm infant successfully treated with oral zinc supplementation: review of zinc metabolism and related diseases. G Ital Dermatol Venereol 2009;144:729-34.
  12. Kienast A, Roth B, Bossier C, Hojabri C, Hoeger PH. Zinc-deficiency dermatitis in breast-fed infants. Eur J Pediatr 2007;166:189-94. https://doi.org/10.1007/s00431-006-0218-9
  13. Oh KI, Kim JH, Lee JE, Lim DH, Son BK. A case of acquired acrodermatitis enteropathica with a normal serum zinc level but a low level in the hair. Korean J Pediatr 2007;50:209-12. https://doi.org/10.3345/kjp.2007.50.2.209
  14. Song JK, Kim SJ, Kang JH, Jung GY. A case of transient symptomatic zinc deficiency. J Korean Soc Neonatol 1998;5:100-3.