Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
권호 표지

The Influences of White Matter Hyperintensities on the Specific Cognitive Decline in the Patients with Mild Cognitive Impairment

백질 고신호 병변이 경도인지장애 환자의 인지영역 기능 저하에 미치는 영향

  • Ku, Bon D. (Department of Neurology, Kwandong University College of Medicine) ;
  • Park, Key Chung (Department of Neurology, KyungHee University School of Medicine)
  • 구본대 (관동대학교 의과대학 의학과 신경과학교실) ;
  • 박기정 (경희대학교 의학전문대학원 의학과 신경과학교실)
  • Published : 2011.03.31
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Abstract

Background: It is still unclear that white matter hyperintensities (WMH) would affect the specific cognitive decline of the patients with mild cognitive impairment (MCI). We explored whether WMH influence the specific cognitive decline to the patient with MCI. Methods: Patients with MCI were recruited from August 2005 to February 2009. We evaluated the degree of WMH by the combination of deep and periventricular WMH. Patients with MCI were divided into groups with minimal (Group I), moderate (Group II) and severe (Group III) hyperintensities by the degree of WMH. Being regarded as subcortical vascular MCI, the patients in the Group III were excluded. According to the affected cognitive domain, patients were divided into amnestic single, amnestic multiple, non-amnestic single and non-amnestic multiple MCI. Results: A total of 156 patients were recruited (118 in Group I and 38 in Group II). Mean score of MMSE was 24.9${\pm}$3.1 and that of CDR was 0.5${\pm}$0.1. The most frequent subtype was amnestic multiple MCI (67.9%). There were no differences in the affected cognitive domains and distribution of the MCI subtype between Group I and Group II. However, the frontal cognitive function declined significantly, in proportion to the increasing periventricular WMH. Conclusions: These results suggest that increasing of periventricular WMH may affect to the frontal cognitive decline in patients with MCI.

Keywords

References

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