The Korean Journal of Medicine

  • 제80권4호
  • /
  • Pages.469-472
  • /
  • 2011
  • /
  • 1738-9364(pISSN)
  • /
  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지

최소변화콩팥병증 환자에 동반된 얇은기저막병 1예

Concurrent Thin Basement Membrane Disease and Minimal Change Disease: A Case Report

  • 서재원 (서울보훈병원 신장내과) ;
  • 임병훈 (서울보훈병원 신장내과) ;
  • 이현정 (서울보훈병원 신장내과) ;
  • 강은미 (서울보훈병원 신장내과) ;
  • 이병욱 (서울보훈병원 신장내과) ;
  • 김범 (서울보훈병원 신장내과) ;
  • 조영미 (울산대학교 의과대학 서울아산병원 병리과)
  • Seo, Jae-Won (Department of Internal Medicine, Seoul Veterans Hospital) ;
  • Lim, Byung-Hoon (Department of Internal Medicine, Seoul Veterans Hospital) ;
  • Lee, Hyun-Jeong (Department of Internal Medicine, Seoul Veterans Hospital) ;
  • Kang, Eun-Mi (Department of Internal Medicine, Seoul Veterans Hospital) ;
  • Lee, Byung-Uk (Department of Internal Medicine, Seoul Veterans Hospital) ;
  • Kim, Beom (Department of Internal Medicine, Seoul Veterans Hospital) ;
  • Cho, Yong-Mee (Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine)
  • 발행 : 2011.04.01
⟨ 이전 논문 다음 논문 ⟩

초록

저자들은 최소변화콩팥병증에 동반된 얇은기저막병 증례를 경험하였으며, 통상적인 고용량 스테로이드 치료에 좋은 반응을 보였다. 향후 우리나라 성인에 있어서 얇은기저막병이 동반된 최소변화콩팥병증의 임상상에 대한 자료 수집과 분석이 필요할 것으로 생각된다.

Thin basement membrane disease is defined as diffuse thinning of the glomerular basement membrane, and is clinically characterized by persistent hematuria, minimal proteinuria, normal renal function, and a benign course. It can occur together with other glomerular diseases. We experienced a case of thin basement membrane disease concurrent with minimal-change disease. Treatment with corticosteroid resulted in improved proteinuria and peripheral edema during the follow-up period.

키워드

참고문헌

  1. Rogers PW, Kurtzman NA, Bunn SM Jr, White MG. Familial benign essential hematuria. Arch Intern Med 1973;131:257-262. https://doi.org/10.1001/archinte.1973.00320080093013
  2. Abe S, Amagasaki Y, Iyori S, et al. Thin basement membrane syndrome in adults. J Clin Pathol 1987;40:318-322. https://doi.org/10.1136/jcp.40.3.318
  3. Aarons I, Smith PS, Davies RA, Woodroffe AJ, Clarkson AR. Thin membrane nephropathy: a clinico-pathological study. Clin Nephrol 1989;32:151-158.
  4. Tiebosch AT, Frederik PM, van Breda Vriesman PJ, et al. Thin-basement-membrane nephropathy in adults with persistent hematuria. N Engl J Med 1989;320:14-18. https://doi.org/10.1056/NEJM198901053200103
  5. Sue YM, Huang JJ, Hsieh RY, Chen FF. Clinical features of thin basement membrane disease and associated glomerulopathies. Nephrology 2004;9:14-18. https://doi.org/10.1111/j.1440-1797.2003.00223.x
  6. Tóth T, Naito I, Takebayashi S. Diffuse thin glomerular basement membrane in association with idiopathic membranous glomerulonephritis. Clin Nephrol 1998;50:137-143.
  7. 김창우, 조민현, 고철우, 구자훈, 곽정식. 사구체 기저막 비박화 소견을 보인 미세변화 신증후군에 관한 고찰. 대한소아신장학회지 2002;6:48-55.
  8. 최혁준, 이현철, 장민화 등. 성인 비박형 사구체 기저막질환 (Thin Glomerular Basement Membrane Disease: TGBMD)의 임상소견. 대한신장학회 2002;21:163.
  9. 김종화, 심윤숙, 박재호 등. 얇은 사구체기저막병(Thin Basement Membrane Disease)이 동반된 미세변화신질환 1예. 대한신장학회 2006;25:274.
  10. 정재권, 황중하, 김성호 등. 비박성 기저막 신병증을 동반한 미세 변화 신증후군 1례. 대한신장학회 2003;22:229.
  11. Cosio FG, Falkenhain ME, Sedmak DD. Association of thin glomerular basement membrane with other glomerulopathies. Kidney Int 1994;46:471-474. https://doi.org/10.1038/ki.1994.296
  12. Coleman M, Stirling JW. Glomerular basement membrane thinning is acquired in minimal change disease. Am J Nephrol 1991;11:437-438. https://doi.org/10.1159/000168352
  13. Monnens LA. Thin glomerular basement membrane disease. Kidney Int 2001;60:799-800. https://doi.org/10.1046/j.1523-1755.2001.060002799.x
  14. 서영미, 정재걸, 유은실, 정진영, 박영서. 미세변화 신증후군의 임상소견을 보인 비박형 기저막신증 2예. 소아과 2000;43:978-982.
  15. Wolf G, Sharma K, Chen Y, Ericksen M, Ziyadeh FN. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta. Kidney Int 1992;42:647-656. https://doi.org/10.1038/ki.1992.330
  16. Shigematsu H, Kobayashi Y, Tateno S, Hiki Y, Kuwao S. Ultrastructural glomerular loop abnormalities in IgA nephritis. Nephron 1982;30:1-7. https://doi.org/10.1159/000182423
  17. Norby SM, Cosio FG. Thin basement membrane nephropathy associated with other glomerular diseases. Semin Nephrol 2005;25:176-179. https://doi.org/10.1016/j.semnephrol.2005.01.010
  18. Waldman M, Crew RJ, Valeri A, et al. Adult minimal-change disease: clinical characteristics, treatment, and outcomes. Clin J Am Soc Nephrol 2007;2:445-453. https://doi.org/10.2215/CJN.03531006