The Korean Journal of Medicine

  • 제80권4호
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  • Pages.405-407
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  • 2011
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지

프로톤펌프억제제와 클로피도그렐(clopidogrel) 병용투여는 안전한가?

Proton Pump Inhibitors with Clopidogrel: Is There Benefit or Harm?

  • 전성우 (경북대학교 의학전문대학원 내과학교실)
  • Jeon, Seong-Woo (Department of Internal Medicine, Kyungpook National University School of Medicine)
  • 발행 : 2011.04.01
⟨ 이전 논문 다음 논문 ⟩

초록

The treatment of acute coronary syndromes involves a combination of antiplatelet therapies. Proton pump inhibitors (PPIs) are often recommended for prophylaxis of gastrointestinal bleeding. Recent studies have shown that the cardiovascular harmful effects of the combination therapy with these two drugs cause serious results in patients with acute coronary syndrome. However, the data on this subject, especially on the clinical outcomes, are conflicting. Based on the available data, the decision to prescribe a PPI to a patient on clopidogrel should be done after evaluation of the cardiovascular risk and the gastrointestinal benefit. Further prospective randomized trials are needed to jump to the conclusions.

키워드

참고문헌

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