Clinical Endoscopy

The Korean Society of Gastrointestinal Endoscopy (대한소화기내시경학회)
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A Case of Gastrointestinal Amyloidosis as a Complication of Crohn's Disease

크론병에서 발생한 위장관 아밀로이드증 1예

  • Park, Kee-Tae (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute) ;
  • Kang, Dae-Hwan (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute) ;
  • Choi, Cheol-Woong (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute) ;
  • Park, Su-Bum (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute) ;
  • Lee, Jae-Hyung (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute) ;
  • Kim, Bong-Gap (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute) ;
  • Kim, Suk-Hun (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute) ;
  • Kim, Hyung-Wook (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute)
  • 박기태 (부산대학교 의학전문대학원 양산부산대학교병원 내과학교실) ;
  • 강대환 (부산대학교 의학전문대학원 양산부산대학교병원 내과학교실) ;
  • 최철웅 (부산대학교 의학전문대학원 양산부산대학교병원 내과학교실) ;
  • 박수범 (부산대학교 의학전문대학원 양산부산대학교병원 내과학교실) ;
  • 이재형 (부산대학교 의학전문대학원 양산부산대학교병원 내과학교실) ;
  • 김봉갑 (부산대학교 의학전문대학원 양산부산대학교병원 내과학교실) ;
  • 김석훈 (부산대학교 의학전문대학원 양산부산대학교병원 내과학교실) ;
  • 김형욱 (부산대학교 의학전문대학원 양산부산대학교병원 내과학교실)
  • Published : 2011.06.30
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Abstract

Amyloidosis is a disorder resulting from extracellular deposition of insoluble fibrils and causes dysfunction in many organs. Secondary amyloidosis, caused by chronic infectious and inflammatory disease, may involve the kidneys, liver, bone marrow and gastrointestinal tract. Involvement of the gastrointestinal tract is common and presents various symptoms according to location. Amyloidosis as a complication of Crohn's disease is a rare but serious complication that may worsen the prognosis. We report a case of gastrointestinal amyloidosis in a 59-year-old male patient with Crohn's disease that was diagnosed with an endoscopic forceps biopsy of the stomach, terminal ileum and colon.

아밀로이드증은 아밀로이드라는 불용성의 섬유단백이 세포외에 침착한 질환으로 침범된 장기의 부전을 일으킬 수 있다. 속발성 아밀로이드증은 만성 염증이나 감염 질환에 관련하여 생기는 질환으로 신장, 간, 골수, 위장관 등에서 발생한다. 위장관은 아밀로이드증이 흔히 침범하는 장기 중 하나로, 침범한 위치에 따라 다양한 증상과 임상경과를 보인다. 크론병에서 발생한 속발성 아밀로이드증은 드물지만 불량한 예후를 보이며 남자에서 흔하다. 저자들은 7년 전 크론병 진단 후 치료 중인 59세 남자가 반복되는 설사와 복통으로 내원하여 위, 회장 말단과 대장에서 시행한 점막 조직 생검을 통해 속발성 아밀로이드증으로 진단한 1예를 경험하여서 문헌고찰과 함께 보고한다.

Keywords

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