Korean Circulation Journal

  • 제41권11호
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  • Pages.649-653
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  • 2011
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Predictors of Echocardiographic Progression in Patients With Mild Aortic Stenosis

  • Seo, Jeong-Sook (Department of Cardiology, College of Medicine, Inje University, Pusan Paik Hospital) ;
  • Kang, Duk-Hyun (Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Dae-Hee (Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Song, Jong-Min (Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Song, Jae-Kwan (Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center)
  • 발행 : 2011.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: The factors related to the progression of mild aortic stenosis (AS) remain unknown. We wanted to evaluate the long-term outcomes and predictors of echocardiographic progression in patients with mild AS. Subjects and Methods: We prospectively included 103 consecutive asymptomatic patients (62.1${\pm}$11.9 years, 31 males) with mild AS. Mild AS was defined as aortic valve (AV) thickening accompanied by a peak aortic jet velocity (AV Vmax) $\geq$2.0 and <3.0 m/sec, and rapid progression of AS was defined as an average annual increase in the AV Vmax $\geq$0.2 m/sec, and cardiac events were defined as cardiac death or AV replacement. Results: During a median echocardiographic follow-up time of 6.0 years, the average change in the AV Vmax was 0.08${\pm}$0.10 m/sec per year. The rate of progression was significantly associated with age, moderate-to-severe AV calcification and the baseline AV Vmax, but not with the serum cholesterol level. The baseline AV Vmax (2.6${\pm}$0.3 m/sec vs. 2.2${\pm}$0.3 m/sec, respectively, p<0.001) and the incidence of moderate-to-severe AV calcification (92.9% vs. 36.5%, respectively, p<0.001) were significantly higher in the rapid progression group than in the slow progression group. The 7-year cardiac event-free survival rate was lower in the rapid progression group than in the slow pro-gression group (87.5${\pm}$8.3% vs. 100%, respectively). Conclusion: The progression of AS was slower than expected and it was re-lated to age, the baseline AV Vmax and AV calcification. Because of the marked individual variability in progression, the patients showing rapid progression of AS need closer follow-up.

키워드

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피인용 문헌

  1. Implementation of diagnosis in asymptomatic patients with aortic stenosis : the Implementation of Diagnosis in asymptomatic patiEnts with Aortic Stenosis registry vol.16, pp.4, 2011, https://doi.org/10.2459/jcm.0000000000000021