옻닭 섭취 후 발생한 급성 콩팥기능상실 동반한 스티븐슨존슨증후군 1예

A Case of Stevens-Johnson Syndrome with Acute Renal Failure Induced by Rhus-Chicken Ingestion

  • Kang, Dong-Yoon (Department of Internal Medicine, Good Gang-An Hospital) ;
  • Kim, Min-Sung (Department of Internal Medicine, Good Gang-An Hospital) ;
  • Yoon, Sang-Suk (Department of Internal Medicine, Good Gang-An Hospital) ;
  • Yun, Tack-Su (Department of Internal Medicine, Good Gang-An Hospital) ;
  • Jeong, Dong-Il (Department of Internal Medicine, Good Gang-An Hospital) ;
  • Seol, Hee-Yun (Department of Internal Medicine, Good Gang-An Hospital) ;
  • Lee, Yong-Kyu (Department of Internal Medicine, Good Gang-An Hospital)
  • 발행 : 2011.11.01

초록

스티븐스존슨증후군/독성표피괴사융해증은 생명을 위협할 만큼 위험한 질환으로 대개 약물의 부작용으로 발생한다. 그러나 음식물로 인하여 발생하는 경우는 드물며, 특히 옻닭 섭취 후 발생한 스티븐스존슨증후군/독성표피괴사융해증의 보고는 없었다. 이에 저자들은 특별한 약물 복용력 없이 옻닭 섭취 후 급성콩팥기능상실을 동반하여 발생한 스티븐슨존슨증후군/독성표피괴사융해증을 진단하고 치료한 경험 1예가 있어 문헌고찰과 함께 보고한다.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, diffuse mucocutaneous reactions that can be elicited by drugs, infection, malignancy, and herbal supplements. A wide variety of mucocutaneous events, such as systemic contact dermatitis, have been reported to be elicited by Rhus chicken, although cases of SJS and TEN are rare. Here, we present a case of SJS caused by Rhus-chicken ingestion. A 48-year-old man who wanted to improve his health and treat a gastrointestinal problem ingested Rhus chicken in the traditional manner. Twenty-four hours later, he developed a multiple erythematous maculopapular skin rash with vesicles and bullaes on 30% of the body surface and multiple erosions on the lips. He was diagnosed with SJS/TEN and showed characteristic clinical findings induced by Rhus chicken. After the patient stopped Rhus-chicken ingestion and received methylprednisolone and antibiotics, his symptoms, signs, and laboratory findings improved. With this case, we emphasize that SJS and TEN can occur after ingesting Rhus chicken, although the incidence is very low.

키워드

참고문헌

  1. Park SD. Herb medicine-inducedadverse effects in dermatological field. J Korean Med Assoc 2005 April 30 [Epub]. http://dx. doi.org/10.5124/jkma.2005.48.4.325.
  2. Kim KJ, Lee SY, Choi KC, Chung BS. Differences in Antigen-presenting cells in dermatitis due to skin contact and ingestion of lacquer tree. Korean J Dermatol 2001;39:1238-1245.
  3. Won TH, Seo PS, Park SD, Kim DL, Park JH. Clinical features in 147 patients with systemic contact dermatitisdue to the ingestion of chicken boiled with japanese lacquer tree. Korean J Dermatol 2008;46:761-768.
  4. Cohen LM, Cohen JL. Erythema multiforme associated with contact dermatitis to poison ivy: three cases and a review of the literature. Cutis 1998;62:139-142.
  5. Trent J, Halem M, French LE, Kerdel F. Toxic epidermal necrolysis and intravenous immunoglobulin: a review. Semin Cutan Med Surg 2006;25:91-93. https://doi.org/10.1016/j.sder.2006.04.004
  6. French LE. Toxic epidermal necrolysis and Stevens Johnson syndrome: our current understanding. Allergol Int 2006;55:9-16. https://doi.org/10.2332/allergolint.55.9
  7. Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994;331:1272-1285. https://doi.org/10.1056/NEJM199411103311906
  8. Roujeau JC, Kelly JP, Naldi L, et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med 1995;333:1600-1607. https://doi.org/10.1056/NEJM199512143332404
  9. Bastuji-Garin S, Fouchard N, Bertocchi M, Roujeau JC, Revuz J, Welkenstein P. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol 2000;115:149-153. https://doi.org/10.1046/j.1523-1747.2000.00061.x
  10. Harr T, French LE. Severe cutaneousadverse reactions: acute generalized exanthematous pustulosis, toxic epidermal necrolysis and Stevens-Johnson syndrome. Med Clin North Am 2010;94: 727-742. https://doi.org/10.1016/j.mcna.2010.04.004
  11. Fournier S, Bastuji-Garin S, Mentec H, Revuz J, Roujeau JC. Toxic epidermal necrolysis associated with mycoplasma pneumoniae infection. Eur J Clin Microbiol Infect Dis 1995; 14:558-559. https://doi.org/10.1007/BF02113442
  12. Avakian R, Flowers FP, Araujo OE, Ramos-Caro FA. Toxic epidermal necrolysis: a review. J Am Acad Dermatol 1991;25(1 Pt 1):69-79. https://doi.org/10.1016/0190-9622(91)70176-3
  13. Lee JH, Lee YM. A case of Stevens-Johnson syndrome caused by ciprofloxacin. Korean J Med 2008;75:909-912.
  14. Ma JE, Kim HS, Park DJ, et al. A case of Stevens-Johnson syndrome induced by gabapentin. Korean J Asthma Allergy Clin Immunol 2007;27:283-286.
  15. Chung WH, Hung SI, Yang JY, et al. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med 2008;14:1343-1350. https://doi.org/10.1038/nm.1884
  16. Mangla K, Rastogi S, Goyal P, Solanki RB, Rawal RC. Efficacy of low dose intravenous immunoglobulins in children with toxic epidermal necrolysis: an open uncontrolled study. Indian J Dermatol Venereol Leprol 2005;71:398-400. https://doi.org/10.4103/0378-6323.18943
  17. Tristani-Firouzi P, Petersen MJ, Saffle JR, Morris SE, Zone JJ. Treatment of toxic epidermal necrolysis with intravenous immunoglobulin in children. J Am Acad Dermatol 2002;47: 548-552. https://doi.org/10.1067/mjd.2002.127249
  18. Zipitis CS, Thalange N. Intravenous immunoglobulins for the management of Stevens-Johnson syndrome with minimal skin manifestations. Eur J Pediatr 2007;166:585-588. https://doi.org/10.1007/s00431-006-0287-9
  19. Wolf R, Davidovici B. Severe cutaneous adverse drug reactions: who should treat, where and how? Facts and controversies. Clin Dermatol 2010;28:344-348. https://doi.org/10.1016/j.clindermatol.2009.06.020
  20. De Prost N, Ingen-Housz-Oro S, Duong T, et al. Bacteremia in Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiology, risk factors, and predictive value of skin cultures. Medicine (Baltimore) 2010;89:28-36. https://doi.org/10.1097/MD.0b013e3181ca4290