The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Overlap Syndrome of Antisynthetase Syndrome and Rheumatoid Arthritis: A Case Report

항합성효소증후군과 류마티스 관절염의 중첩증후군 1예

  • Jang, Hui-Won (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Ha, You-Jung (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kang, Yoon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lee, Kwang-Hoon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Park, Yong-Beom (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lee, Soo-Kon (Department of Internal Medicine, Yonsei University College of Medicine)
  • 장희원 (연세대학교 의과대학 내과학교실) ;
  • 하유정 (연세대학교 의과대학 내과학교실) ;
  • 강윤 (연세대학교 의과대학 내과학교실) ;
  • 이광훈 (연세대학교 의과대학 내과학교실) ;
  • 박용범 (연세대학교 의과대학 내과학교실) ;
  • 이수곤 (연세대학교 의과대학 내과학교실)
  • Published : 2011.11.01
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Abstract

The antisynthetase syndrome is characterized by anti-Jo-1 antibody production, interstitial lung disease, inflammatory muscle disease, and, in many cases, fever, polyarthritis, Raynaud's phenomenon, and mechanic's hands. Joint signs and symptoms occur in up to 90% of patients with antisynthetase syndrome, occasionally as the initial manifestations. Although visual inspection of the hands shows changes that are highly suggestive of rheumatoid arthritis, notable differences exist. Antisynthetase syndrome is a predominantly nonerosive arthropathy with subluxations of the distal interphalangeal joints. It manifests as overlap syndrome with other connective tissue diseases. However, overlap syndrome of antisynthetase syndrome and rheumatoid arthritis is rare. We treated a 51-year-old male patient with overlap syndrome of antisynthetase syndrome and rheumatoid arthritis, and report the case with a review of the literature.

저자들은 관절염과 근염을 동반한 중년 남성에서 류마티스 관절염과 항합성효소증후군이 동반된 중첩증후군을 진단하고 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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