Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
권호 표지
DOI QR코드

DOI QR Code

A Comparison of the Use of Contrast Media with Different Iodine Concentrations for Multidetector CT of the Kidney

  • Jung, Seung-Chai (Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Institute of Radiation Medicine and Kidney Research Institute, Seoul National University Medical Research Center) ;
  • Kim, Seung-Hyup (Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Institute of Radiation Medicine and Kidney Research Institute, Seoul National University Medical Research Center) ;
  • Cho, Jeong-Yeon (Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Institute of Radiation Medicine and Kidney Research Institute, Seoul National University Medical Research Center)
  • Published : 2011.12.01
⟨ Previous Next ⟩

Abstract

Objective: To determine the optimal iodine concentration of contrast media for kidney multidetector computed tomography (MDCT) by comparing the degree of renal parenchymal enhancement and the severity of the renal streak artifact with contrast media of different iodine concentrations. Materials and Methods: A 16-row MDCT was performed in 15 sedated rabbits by injection of 2 mL contrast media/kg body weight at a rate of 0.3 mL/sec. Monomeric nonionic contrast media of 250, 300, and 370 mg iodine/mL were injected at 1-week intervals. Mean attenuation values were measured in each renal structure with attenuation differences among the structures. The artifact was evaluated by CT window width/level and three grading methods. The values were compared with iodine concentrations. Results: The 370 mg iodine/mL concentration showed significantly higher cortical enhancement than 250 mg iodine/mL in all phases (p < 0.05). There was however no significant difference in the degree of enhancement between the 300 mg iodine/mL and 370 mg iodine/mL concentrations in all phases. There is a significant difference in attenuation for the cortex-outer medulla between 250 mg iodine/mL and 300 mg iodine/mL (p < 0.05). The artifact was more severe with a medium of 370 mg iodine/mL than with 250 mg iodine/mL by all grading methods (p < 0.05). Conclusion: The 300 mg iodine/mL is considered to be the most appropriate iodine concentration in an aspect of the enhancement and artifact on a kidney MDCT scan.

Keywords

References

  1. Marchiano A, Spreafico C, Lanocita R, Frigerio L, Di Tolla G, Patelli G, et al. Does iodine concentration affect the diagnostic efficacy of biphasic spiral CT in patients with hepatocellular carcinoma? Abdom Imaging 2005;30:274-280 https://doi.org/10.1007/s00261-004-0233-0
  2. Yamashita Y, Komohara Y, Takahashi M, Uchida M, Hayabuchi N, Shimizu T, et al. Abdominal helical CT: evaluation of optimal doses of intravenous contrast material--a prospective randomized study. Radiology 2000;216:718-723 https://doi.org/10.1148/radiology.216.3.r00se26718
  3. Fenchel S, Fleiter TR, Aschoff AJ, van Gessel R, Brambs HJ, Merkle EM. Effect of iodine concentration of contrast media on contrast enhancement in multislice CT of the pancreas. Br J Radiol 2004;77:821-830 https://doi.org/10.1259/bjr/19527646
  4. Cademartiri F, Mollet NR, van der Lugt A, McFadden EP, Stijnen T, de Feyter PJ, et al. Intravenous contrast material administration at helical 16-detector row CT coronary angiography: effect of iodine concentration on vascular attenuation. Radiology 2005;236:661-665 https://doi.org/10.1148/radiol.2362040468
  5. Sandstede JJ, Kaupert C, Roth A, Jenett M, Harz C, Hahn D. Comparison of different iodine concentrations for multidetector row computed tomography angiography of segmental renal arteries. Eur Radiol 2005;15:1211-1214 https://doi.org/10.1007/s00330-005-2677-1
  6. Sandstede JJ, Werner A, Kaupert C, Roth A, Jenett M, Harz C, et al. A prospective study comparing different iodine concentrations for triphasic multidetector row CT of the upper abdomen. Eur J Radiol 2006;60:95-99 https://doi.org/10.1016/j.ejrad.2006.05.012
  7. Setty BN, Sahani DV, Ouellette-Piazzo K, Hahn PF, Shepard JA. Comparison of enhancement, image quality, cost, and adverse reactions using 2 different contrast medium concentrations for routine chest CT on 16-slice MDCT. J Comput Assist Tomogr 2006;30:818-822 https://doi.org/10.1097/01.rct.0000229999.30897.3b
  8. Bayrak IK, Ozmen Z, Nural MS, Danaci M, Diren B. A comparison of low-dose and normal-dose gadobutrol in MR renography and renal angiography. Korean J Radiol 2008;9:250-257 https://doi.org/10.3348/kjr.2008.9.3.250
  9. Singer AA, Tagliabue JR, Paushter DM, Borkowski GP, Einstein DM. Comparison of iohexol-240 versus iohexol-300 in abdominal CT. Gastrointest Radiol 1992;17:122-124 https://doi.org/10.1007/BF01888525
  10. Furuta A, Ito K, Fujita T, Koike S, Shimizu A, Matsunaga N. Hepatic enhancement in multiphasic contrast-enhanced MDCT: comparison of high- and low-iodine-concentration contrast medium in same patients with chronic liver disease. AJR Am J Roentgenol 2004;183:157-162 https://doi.org/10.2214/ajr.183.1.1830157
  11. Behrendt FF, Mahnken AH, Stanzel S, Seidensticker P, Jost E, Gunther RW, et al. Intraindividual comparison of contrast media concentrations for combined abdominal and thoracic MDCT. AJR Am J Roentgenol 2008;191:145-150 https://doi.org/10.2214/AJR.07.3176
  12. Tozaki M, Naruo K, Fukuda K. Dynamic contrast-enhanced MDCT of the liver: analysis of the effect of different iodine concentrations with the same total iodine dose in the same chronic liver disease patients. Radiat Med 2005;23:533-538
  13. Bae KT, Heiken JP, Brink JA. Aortic and hepatic contrast medium enhancement at CT. Part I. Prediction with a computer model. Radiology 1998;207:647-655 https://doi.org/10.1148/radiology.207.3.9609886
  14. Bae KT, Tran HQ, Heiken JP. Uniform vascular contrast enhancement and reduced contrast medium volume achieved by using exponentially decelerated contrast material injection method. Radiology 2004;231:732-736 https://doi.org/10.1148/radiol.2313030497
  15. Bae KT, Heiken JP, Brink JA. Aortic and hepatic contrast medium enhancement at CT. Part II. Effect of reduced cardiac output in a porcine model. Radiology 1998;207:657-662 https://doi.org/10.1148/radiology.207.3.9609887
  16. Tello R, Seltzer S. Effects of injection rates of contrast material on arterial phase hepatic CT. AJR Am J Roentgenol 1999;173:237-238 https://doi.org/10.2214/ajr.173.1.10397134
  17. Sussman SK, Illescas FF, Opalacz JP, Yirga P, Foley LC. Renal streak artifact during contrast-enhanced CT: comparison of low versus high osmolality contrast media. Abdom Imaging 1993;18:180-185
  18. Tsurusaki M, Sugimoto K, Fujii M, Sugimura K. Multi-detector row helical CT of the liver: quantitative assessment of iodine concentration of intravenous contrast material on multiphasic CT--a prospective randomized study. Radiat Med 2004;22:239-245
  19. Thomsen HS, Morcos SK, Erley CM, Grazioli L, Bonomo L, Ni Z, et al. The ACTIVE Trial: comparison of the effects on renal function of iomeprol-400 and iodixanol-320 in patients with chronic kidney disease undergoing abdominal computed tomography. Invest Radiol 2008;43:170-178 https://doi.org/10.1097/RLI.0b013e31815f3172
  20. Sultana S, Morishita S, Awai K, Kawanaka K, Ohyama Y, Nakayama Y, et al. Evaluation of hypervascular hepatocellular carcinoma in cirrhotic liver by means of helical CT: comparison of different contrast medium concentrations within the same patient. Radiat Med 2003;21:239-245
  21. Engeroff B, Kopka L, Harz C, Grabbe E. [Impact of different iodine concentrations on abdominal enhancement in biphasic multislice helical CT (MS-CT)]. Rofo 2001;173:938-941 https://doi.org/10.1055/s-2001-17591
  22. Fenchel S, Boll DT, Fleiter TR, Brambs HJ, Merkle EM. Multislice helical CT of the pancreas and spleen. Eur J Radiol 2003;45 Suppl 1:S59-72 https://doi.org/10.1016/S0720-048X(02)00363-7
  23. Young SW, Muller HH, Marshall WH. Computed tomography: beam hardening and environmental density artifact. Radiology 1983;148:279-283 https://doi.org/10.1148/radiology.148.1.6856849
  24. Kuhn MJ, Chen N, Sahani DV, Reimer D, van Beek EJ, Heiken JP, et al. The PREDICT study: a randomized double-blind comparison of contrast-induced nephropathy after low- or isoosmolar contrast agent exposure. AJR Am J Roentgenol 2008;191:151-157 https://doi.org/10.2214/AJR.07.3370

Cited by

  1. Optimizing imaging quality in endourology with the Uro Dyna-CT: contrast agent dilution matters vol.31, pp.5, 2011, https://doi.org/10.1007/s00345-012-0903-4
  2. Imaging Quality Evaluation of Low Tube Voltage Coronary CT Angiography Using Low Concentration Contrast Medium vol.10, pp.3, 2011, https://doi.org/10.1371/journal.pone.0120539
  3. Computed tomography urography with iterative reconstruction algorithm in congenital urinary tract abnormalities in children – association of radiation dose with image quality vol.83, pp.None, 2011, https://doi.org/10.5114/pjr.2018.75808
  4. Use of Iterative Reconstruction and a Small Contrast Volume in Rabbit Kidney CT: Comparison with Conventional Protocol vol.79, pp.2, 2018, https://doi.org/10.3348/jksr.2018.79.2.77