Korean Journal of Radiology

  • 제12권1호
  • /
  • Pages.66-77
  • /
  • 2011
  • /
  • 1229-6929(pISSN)
  • /
  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지
DOI QR코드

DOI QR Code

Serial MR Imaging of Intramuscular Hematoma: Experimental Study in a Rat Model with the Pathologic Correlation

  • Lee, Yeon-Soo (Department of Radiology, Daejeon St. Mary’s Hospital, The Catholic University of Korea) ;
  • Kwon, Soon-Tae (Department of Radiology, Chungnam National University, School of Medicine) ;
  • Kim, Jong-Ok (Department of Pathology, Daejeon St. Mary’s Hospital, The Catholic University of Korea) ;
  • Choi, Eun-Seok (Department of Rehabilitation Medicine, Daejeon St. Mary’s Hospital, The Catholic University of Korea)
  • 발행 : 2011.02.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: We wanted to demonstrate the temporal changes of the magnetic resonance imaging (MRI) findings in experimentally-induced intramuscular hematomas in rats and to correlate these data with the concurrent pathologic observations. Materials and Methods: Intramuscular hematoma was induced in 30 rats. The MR images were obtained at 1, 4, 7 and 10 days and at 2, 3, 4, 6 and 8 weeks after muscle injury. The characteristic serial MRI fi ndings were evaluated and the relative signal intensities were calculated. Pathologic specimens were obtained at each time point. Results: On the T1-weighted imaging (T1WI), the intramuscular hematomas exhibited isointensity compared to that of muscle or the development of a high signal intensity (SI) rim on day one after injury. The high SI persisted until eight weeks after injury. On the T2-weighted imaging (T2WI), the hematomas showed high SI or centrally low SI on day one after injury, and mainly high SI after four days. A dark signal rim was apparent after seven days, which was indicative of hemosiderin on the pathology. The gradient echo (GRE) imaging yielded dark signal intensities at all stages. Conclusion: Unlike brain hematomas, experimentally-induced intramuscular hematomas show increased SI on both the T1WI and T2WI from the acute stage onward, and this is pathologically correlated with a rich blood supply and rapid healing response to injury in the muscle. On the T2WI and GRE imaging, high SI with a peripheral dark signal rim is apparent from seven days to the chronic stage.

키워드

참고문헌

  1. Crundwell N, O'Donnell P, Saifuddin A. Non-neoplastic conditions presenting as soft-tissue tumours. Clin Radiol 2007;62:18-27 https://doi.org/10.1016/j.crad.2006.08.007
  2. Papp DF, Khanna AJ, McCarthy EF, Carrino JA, Farber AJ, Frassica FJ. Magnetic resonance imaging of soft-tissue tumors: determinate and indeterminate lesions. J Bone Joint Surg Am 2007;89:103-115
  3. McKenzie G, Raby N, Ritchie D. Pictorial review: nonneoplastic soft-tissue masses. Br J Radiol 2009;82:775-785 https://doi.org/10.1259/bjr/17870414
  4. Bush CH. The magnetic resonance imaging of musculoskeletal hemorrhage. Skeletal Radiol 2000;29:1-9 https://doi.org/10.1007/s002560050001
  5. Bradley WG Jr. MR appearance of hemorrhage in the brain. Radiology 1993;189:15-26 https://doi.org/10.1148/radiology.189.1.8372185
  6. Di Chiro G, Brooks RA, Girton ME, Caporale T, Wright DC, Dwyer AJ, et al. Sequential MR studies of intracerebral hematomas in monkeys. AJNR Am J Neuroradiol 1986;7:193-199
  7. Allkemper T, Tombach B, Schwindt W, Kugel H, Schilling M, Debus O, et al. Acute and subacute intracerebral hemorrhages: comparison of MR imaging at 1.5 and 3.0 T--initial experience. Radiology 2004;232:874-881 https://doi.org/10.1148/radiol.2323030322
  8. Küllmer K, Sievers KW, Rompe JD, Nägele M, Harland U. Sonography and MRI of experimental muscle injuries. Arch Orthop Trauma Surg 1997;116:357-361 https://doi.org/10.1007/BF00433990
  9. De Smet AA. Magnetic resonance fi ndings in skeletal muscle tears. Skeletal Radiol 1993;22:479-484 https://doi.org/10.1007/BF00209094
  10. Ehman RL, Berquist TH. Magnetic resonance imaging of musculoskeletal trauma. Radiol Clin North Am 1986;24:291-319
  11. De Smet AA, Fisher DR, Heiner JP, Keene JS. Magnetic resonance imaging of muscle tears. Skeletal Radiol 1990;19:283-286 https://doi.org/10.1007/BF00191673
  12. Dooms GC, Fisher MR, Hricak H, Higgins CB. MR imaging of intramuscular hemorrhage. J Comput Assist Tomogr 1985;9:908-913 https://doi.org/10.1097/00004728-198509000-00013
  13. Rybak LD, Torriani M. Magnetic resonance imaging of sportsrelated muscle injuries. Top Magn Reson Imaging 2003;14:209-219 https://doi.org/10.1097/00002142-200304000-00008
  14. Fleckenstein JL, Weatherall PT, Parkey RW, Payne JA, Peshock RM. Sports-related muscle injuries: evaluation with MR imaging. Radiology 1989;172:793-798 https://doi.org/10.1148/radiology.172.3.2772190
  15. Koulouris G, Connell D. Evaluation of the hamstring muscle complex following acute injury. Skeletal Radiol 2003;32:582-589 https://doi.org/10.1007/s00256-003-0674-5
  16. Kneeland JP. MR imaging of muscle and tendon injury. Eur J Radiol 1997;25:198-208
  17. Steinbach L, Fleckenstein JL, Mink JH. Magnetic resonance imaging of muscle injuries. Orthopedics 1994;17:991-999
  18. Connell DA, Schneider-Kolsky ME, Hoving JL, Malara F, Buchbinder R, Koulouris G, et al. Longitudinal study comparing sonographic and MRI assessments of acute and healing hamstring injuries. AJR Am J Roentgenol 2004;183:975-984 https://doi.org/10.2214/ajr.183.4.1830975
  19. Weishaupt D, Schweitzer ME, Morrison WB. Injuries to the distal gastrocnemius muscle: MR findings. J Comput Assist Tomogr 2001;25:677-682 https://doi.org/10.1097/00004728-200109000-00003
  20. Bohndorf K, Kilcoyne RF. Traumatic injuries: imaging of peripheral musculoskeletal injuries. Eur Radiol 2002;12:1605-1616 https://doi.org/10.1007/s00330-002-1461-8
  21. Mellerowicz H, Lubasch A, Dulce MC, Dulce K, Wagner S, Wolf KJ. Diagnosis and follow-up of muscle injuries by means of plain and contrast-enhanced MRT: experimental and clinical studies. Rofo 1997;166:437-445 [German] https://doi.org/10.1055/s-2007-1015454
  22. Niemi P, Paajanen H, Kormano M, Alanen A, Maattanen H, Dean PB. MR imaging of experimental intramuscular hemorrhage at 0.02 T. Contrast enhancement with Gd-DOTA. Acta Radiol 1990;31:455-458 https://doi.org/10.1177/028418519003100506
  23. Hurme T, Kalimo H, Lehto M, Jarvinen M. Healing of skeletal muscle injury: an ultrastructural and immunohistochemical study. Med Sci Sports Exerc 1991;23:801-810
  24. Kaariainen M, Kaariainen J, Jarvinen TL, Sievanen H, Kalimo H, Jarvinen M. Correlation between biomechanical and structural changes during the regeneration of skeletal muscle after laceration injury. J Orthop Res 1998;16:197-206 https://doi.org/10.1002/jor.1100160207
  25. Terada N, Takayama S, Yamada H, Seki T. Muscle repair after a transsection injury with development of a gap: an experimental study in rats. Scand J Plast Reconstr Surg Hand Surg 2001;35:233-238 https://doi.org/10.1080/028443101750523131
  26. Sanchez-Marquez A, Gil-Garcaa M, Valls C, Portabella-Blavia F, Narvaez-Garcia J, Andia-Navarro E, et al. Sports-related muscle injuries of the lower extremity: MR imaging appearances. Eur Radiol 1999;9:1088-1093 https://doi.org/10.1007/s003300050795
  27. Brooks RA, Di Chiro G, Patronas N. MR imaging of cerebral hematomas at different fi eld strengths: theory and applications. J Comput Assist Tomogr 1989;13:194-206 https://doi.org/10.1097/00004728-198903000-00002
  28. Edelman RR, Johnson K, Buxton R, Shoukimas G, Rosen BR, Davis KR, et al. MR of hemorrhage: a new approach. AJNR Am J Neuroradiol 1986;7:751-756
  29. Boutin RD, Fritz RC, Steinbach LS. Imaging of sports-related muscle injuries. Radiol Clin North Am 2002;40:333-362 https://doi.org/10.1016/S0033-8389(02)00008-8
  30. El-Khoury GY, Brandser EA, Kathol MH, Tearse DS, Callaghan JJ. Imaging of muscle injuries. Skeletal Radiol 1996;25:3-11 https://doi.org/10.1007/s002560050024

피인용 문헌

  1. Quantitative assessment of changes in carotid plaques during cilostazol administration using three-dimensional ultrasonography and non-gated magnetic resonance plaque imaging vol.54, pp.9, 2011, https://doi.org/10.1007/s00234-012-1011-2
  2. Relation between microcurrent therapy and satellite cells in the regeneration of induced skeletal muscle injury in rat : vol.36, pp.2, 2011, https://doi.org/10.1097/01.ehx.0000428366.81246.0a
  3. Possible Local Stem Cells Activation by Microcurrent Application in Experimentally Injured Soleus Muscle vol.7, pp.2, 2014, https://doi.org/10.15283/ijsc.2014.7.2.79
  4. A Potential Diagnostic Pitfall in the Differentiation of Hemorrhagic and Fatty Lesions Using Short Inversion Time Inversion Recovery: a Case Report vol.20, pp.3, 2011, https://doi.org/10.13104/imri.2016.20.3.181
  5. Malignant Lymphoma in the Psoas Major Muscle vol.2017, pp.None, 2011, https://doi.org/10.1155/2017/3902748
  6. MRI appearance does not change in the first 7 days after acute hamstring injury—a prospective study vol.51, pp.14, 2011, https://doi.org/10.1136/bjsports-2016-096881
  7. L’IRM des lésions musculaires du sportif vol.98, pp.6, 2011, https://doi.org/10.1016/j.jradio.2017.09.007
  8. Hemorrhage of MRI and Immunohistochemical Panels Distinguish Secretory Carcinoma From Acinic Cell Carcinoma vol.3, pp.4, 2011, https://doi.org/10.1002/lio2.169
  9. Multimodality Imaging of Foreign Bodies: New Insights into Old Challenges vol.40, pp.7, 2011, https://doi.org/10.1148/rg.2020200061