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Comparison of Clinico-Radiological Features between Congenital Cystic Neuroblastoma and Neonatal Adrenal Hemorrhagic Pseudocyst

  • Eo, Hong (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Ji-Hye (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jang, Kyung-Mi (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Yoo, So-Young (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lim, Gye-Yeon (Department of Radiology, St. Mary’s Hospital Catholic University) ;
  • Kim, Myung-Joon (Department of Radiology, Severance Hospital Yonsei University) ;
  • Kim, Ok-Hwa (Department of Radiology, Ajou University Hospital)
  • 발행 : 2011.02.01

초록

Objective: To evaluate the radiological and clinical fi ndings of congenital cystic neuroblastomas as compared with those of the cystic presentation of neonatal adrenal hemorrhage. Materials and Methods: We analyzed the US (n = 52), CT (n = 24), and MR (n = 4) images as well as the medical records of 28 patients harboring congenital cystic neuroblastomas (n = 16) and neonatal adrenal hemorrhagic pseudocysts (n = 14). The history of prenatal detection, location, size, presence of outer wall enhancement, internal septations, solid portion, calcifi cation, turbidity, vascular fl ow on a Doppler examination, and evolution patterns were compared in two groups of cystic lesions, by Fischer's exact test. Results: All (100%) neuroblastomas and three (21%) of the 14 hemorrhagic pseudocysts were detected prenatally. Both groups of cystic lesions occurred more frequently on the right side; 11 of 16 (69%) for neuroblastomas and 11 of 14 (79%) for hemorrhagic pseudocysts. The size, presence of solid portion, septum, enhancement, and turbidity did not differ signifi cantly (p > 0.05) between the two groups of cystic lesions. However, tiny calcifi cations (n = 3) and vascular fl ow on color Doppler US (n = 3) were noted in only neuroblastomas. The cystic neuroblastomas became complex solid and cystic masses, and did not disappear for up to 90 days in the three following cases, whereas 11 of the 14 (79%) hemorrhagic pseudocysts disappeared completely and the three remaining (27%) evolved to calcifi cations only. Conclusion: Although the imaging fi ndings of two groups of cystic lesions were similar, prenatal detection, the presence of calcifi cation on initial images, vascularity on color Doppler US, and evolution to a more complex mass may all favor neuroblastomas.

키워드

참고문헌

  1. Lee J, Park CM, Kim KA, Lee CH, Choi JW, Shin BK, et al. Cystic lesions of the gastrointestinal tract: multimodality imaging with pathologic correlations. Korean J Radiol 2010; 11:457-468 https://doi.org/10.3348/kjr.2010.11.4.457
  2. Gotoh T, Adachi Y, Nounaka O, Mori T, Koyanagi T. Adrenal hemorrhage in the newborn with evidence of bleeding in utero. J Urol 1989;141:1145-1147 https://doi.org/10.1016/S0022-5347(17)41195-5
  3. Acharya S, Jayabose S, Kogan SJ, Tugal O, Beneck D, Leslie D, et al. Prenatally diagnosed neuroblastoma. Cancer 1997;80:304-310 https://doi.org/10.1002/(SICI)1097-0142(19970715)80:2<304::AID-CNCR19>3.0.CO;2-Y
  4. Stevens MC. Neonatal tumours. Arch Dis Child 1988;63:1122-1125 https://doi.org/10.1136/adc.63.10_Spec_No.1122
  5. Eklof O, Mortensson W, Sandstedt B. Suprarenal haematoma versus neuroblastoma complicated by haemorrhage. A diagnostic dilemma in the newborn. Acta Radiol Diagn (Stockh) 1986;27:3-10 https://doi.org/10.1177/028418518602700102
  6. Atkinson GO Jr, Zaatari GS, Lorenzo RL, Gay BB Jr, Garvin AJ. Cystic neuroblastoma in infants: radiographic and pathologic features. AJR Am J Roentgenol 1986;146:113-117 https://doi.org/10.2214/ajr.146.1.113
  7. Chen CP, Chen SH, Chuang CY, Lee HC, Hwu YM, Chang PY, et al. Clinical and perinatal sonographic features of congenital adrenal cystic neuroblastoma: a case report with review of the literature. Ultrasound Obstet Gynecol 1997;10:68-73 https://doi.org/10.1046/j.1469-0705.1997.10010068.x
  8. Richards ML, Gundersen AE, Williams MS. Cystic neuroblastoma of infancy. J Pediatr Surg 1995;30:1354-1357 https://doi.org/10.1016/0022-3468(95)90504-9
  9. Yamagiwa I, Obata K, Saito H. Prenatally detected cystic neuroblastoma. Pediatr Surg Int 1998;13:215-217 https://doi.org/10.1007/s003830050298
  10. Hamada Y, Ikebukuro K, Sato M, Tanano A, Kato Y, Takada K, et al. Prenatally diagnosed cystic neuroblastoma. Pediatr Surg Int 1999;15:71-74 https://doi.org/10.1007/s003830050518
  11. Vollersen E, Hof M, Gembruch U. Prenatal sonographic diagnosis of fetal adrenal gland hemorrhage. Fetal Diagn Ther 1996;11:286-291 https://doi.org/10.1159/000264316
  12. Burbige KA. Prenatal adrenal hemorrhage confi rmed by postnatal surgery. J Urol 1993;150:1867-1869 https://doi.org/10.1016/S0022-5347(17)35917-7
  13. Yamamoto K, Hanada R, Kikuchi A, Ichikawa M, Aihara T, Oguma E, et al. Spontaneous regression of localized neuroblastoma detected by mass screening. J Clin Oncol 1998;16:1265-1269 https://doi.org/10.1200/JCO.1998.16.4.1265
  14. Deeg KH, Bettendorf U, Hofmann V. Differential diagnosis of neonatal adrenal haemorrhage and congenital neuroblastoma by colour coded Doppler sonography and power Doppler sonography. Eur J Pediatr 1998;157:294-297 https://doi.org/10.1007/s004310050814
  15. Carlsen NL. How frequent is spontaneous remission of neuroblastomas? Implications for screening. Br J Cancer 1990;61:441-446 https://doi.org/10.1038/bjc.1990.97

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