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Spontaneous Spinal Epidural Hematomas Associated With Acute Myocardial Infarction Treatment

  • Yang, Seung-Min (Department of Neurological Surgery, College of Medicine, Chung-Ang University) ;
  • Kang, Suk-Hyung (Department of Neurological Surgery, Chung-Ang University Graduate School) ;
  • Kim, Kyoung-Tae (Department of Neurosurgery, Kyungpook National University Hospital) ;
  • Park, Seung-Won (Department of Neurological Surgery, College of Medicine, Chung-Ang University) ;
  • Lee, Wang-Soo (Division of Cardiology, College of Medicine, Chung-Ang University)
  • Published : 2011.12.30

Abstract

Many studies have reported spontaneous spinal epidural hematoma (SSEH). Although most cases are idiopathic, several are associated with thrombolytic therapy or anticoagulants. We report a case of SSEH coincident with acute myocardial infarction (AMI), which caused serious neurological deficits. A 56 year old man presented with chest pain accompanied with back and neck pain, which was regarded as an atypical symptom of AMI. He was treated with nitroglycerin, aspirin, low molecular weight heparin, and clopidogrel. A spinal magnetic resonance image taken after paraplegia developed 3 days after the initial symptoms revealed an epidural hematoma at the cervical and thoracolumbar spine. Despite emergent decompressive surgery, paraplegia has not improved 7 months after surgery. A SSEH should be considered when patients complain of abrupt, strong, and non-traumatic back and neck pain, particularly if they have no spinal pain history.

Keywords

References

  1. Chan KC, Wu DJ, Ueng KC, et al. Spinal epidural hematoma following tissue plasminogen activator and heparinization for acute myocardial infarction. Jpn Heart J 2002;43:417-21. https://doi.org/10.1536/jhj.43.417
  2. Subbiah M, Avadhani A, Shetty AP, Rajasekaran S. Acute spontaneous cervical epidural hematoma with neurological deficit after low-molecular-weight heparin therapy: role of conservative management. Spine J 2010;10:e11-5.
  3. Akhtar MM, Iqbal YH, Kaski JC. Managing unstable angina and non-ST elevation MI. Practitioner 2010;254:25-30.
  4. Kumar A, Cannon CP. Acute coronary syndromes: diagnosis and management, part I. Mayo Clin Proc 2009;84:917-38. https://doi.org/10.4065/84.10.917
  5. Riegel B, Hanlon AL, McKinley S, et al. Differences in mortality in acute coronary syndrome symptom clusters. Am Heart J 2010;159:392-8. https://doi.org/10.1016/j.ahj.2010.01.003
  6. Lee HO. Typical and atypical clinical signs and symptoms of myocardial infarction and delayed seeking of professional care among blacks. Am J Crit Care 1997;6:7-13.
  7. McSweeney JC, Cody M, O'Sullivan P, Elberson K, Moser DK, Garvin BJ. Women's early warning symptoms of acute myocardial infarction. Circulation 2003;108:2619-23. https://doi.org/10.1161/01.CIR.0000097116.29625.7C
  8. Lee H, Bahler R, Park OJ, Kim CJ, Lee HY, Kim YJ. Typical and atypical symptoms of myocardial infarction among African-Americans, whites, and Koreans. Crit Care Nurs Clin North Am 2001;13:531-9.
  9. Lovlien M, Schei B, Hole T. Women with myocardial infarction are less likely than men to experience chest symptoms. Scand Cardiovasc J 2006;40:342-7. https://doi.org/10.1080/14017430600913199
  10. Atypical presentation of myocardial infarction in the outpatient setting, a lapse in clinical knowledge and inadequate data transfer constitute a potentially fatal error. Int J Qual Health Care 2003;15:179, doi: 10.1093/intqhc/mzg027.
  11. Liu Z, Jiao Q, Xu J, Wang X, Li S, You C. Spontaneous spinal epidural hematoma: analysis of 23 cases. Surg Neurol 2008;69:253-60. https://doi.org/10.1016/j.surneu.2007.02.019
  12. Kitagawa RS, Mawad ME, Whitehead WE, Curry DJ, Luersen TG, Jea A. Paraspinal arteriovenous malformations in children. J Neurosurg Pediatr 2009;3:425-8. https://doi.org/10.3171/2009.2.PEDS08427
  13. Sung JH, Hong JT, Son BC, Lee SW. Clopidogrel-induced spontaneous spinal epidural hematoma. J Korean Med Sci 2007;22:577-9. https://doi.org/10.3346/jkms.2007.22.3.577
  14. Dimou J, Jithoo R, Morokoff A. Spontaneous spinal epidural haematoma in a geriatric patient on aspirin. J Clin Neurosci 2010;17:142-4. https://doi.org/10.1016/j.jocn.2009.03.021
  15. Deger SM, Emmez H, Bahadirli K, et al. A spontaneous spinal epidural hematoma in a hemodialysis patient: a rare entity. Intern Med 2009;48:2115-8. https://doi.org/10.2169/internalmedicine.48.2335
  16. Tagaya A, Miyajima Y, Sakamoto M, et al. Spontaneous spinal epidural hematoma in an infant with undiagnosed hemophilia A. Pediatr Int 2010;52:296-8. https://doi.org/10.1111/j.1442-200X.2010.03033.x
  17. Cultrera F, Passanisi M, Giliberto O, Giuffrida M, Mancuso P, Ventura F. Spinal epidural hematoma following coronary thrombolysis: a case report. J Neurosurg Sci 2004;48:43-7.
  18. Groen RJ, van Alphen HA. Operative treatment of spontaneous spinal epidural hematomas: a study of the factors determining postoperative outcome. Neurosurgery 1996;39:494-508; discussion 508-9.

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