Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
권호 표지

An Association between Factor of Metabolic Syndrome and Serum Levels of Gamma-glutamyltranspeptidse at Age 40 Years

  • Choi, Seok-Cheol (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Seok, Seong-Ja (Department of Clinical Pathology, Sorabol College)
  • Received : 2011.02.01
  • Accepted : 2011.03.23
  • Published : 2011.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

We have evaluated an usefulness and association between serum levels of gamma-glutamyltranspeptiase (GGT) and metabolic syndrome (MS) in 40-year-old men and women. The prevalence of MS in men (11.8%) was higher than that of women (4.0%). Serum levels of GGT were higher in men and women with MS than in them without MS. In the prevalence of higher serum GGT, men group with MS (35.8%) was greater than women group with MS (22.7%). In the relative risk of MS to an increased level of GGT, women group was higher than men group (about 3 times) (female, OR=7.48 vs male, OR=2.46). The present study reveals that routine check of serum GGT in health examination can be useful for the prevention and management of MS including cardiovascular and/or liver diseases.

Keywords

References

  1. Bae JM. Prevalence and associated factors of metabolic syndrome among health examined local residents in an university hospital. Doctoral's dissertation, 2007.
  2. Borud O, Mortensen B, Mikkelsen IM, Leroy P, Wellman M, Huseby NE. Regulation of Gamma-glutamyltransferase in cisplatin-resistant and sensitive colon carcinoma cells after acute cisplatin and oxidative stress exposures. Int J Cancer 2000. 88: 464-468. https://doi.org/10.1002/1097-0215(20001101)88:3<464::AID-IJC20>3.0.CO;2-F
  3. Choi SC, Cho BK, Lee YH, Chang KS. Preoperative levels of hematological and biochemical indices affect perioperative variables in adult patients with coronary artery bypass graft surgery. Experi Biomedi Sciences 2010. 16: 247-258.
  4. Expert Panel on Detection, Evaluation and treatment of High Blood Cholesterol in Adults: Executive summary of the third report of the National Cholesterol Education Program (NCEP): Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adults Treatment Panel III) JAMA. 2001. 285: 2486-2497. https://doi.org/10.1001/jama.285.19.2486
  5. Ford ES, Giles WH. A comparison of the prevalence of the metabolic syndrome using two proposed definitions. Diabetes Care 2003. 26: 575-581. https://doi.org/10.2337/diacare.26.3.575
  6. Godsland IF, Leyva F, Walton C, Worthington M, Stevenson JC. Association of smoking, alcohol and physical activity with risk factors for coronary heart disease and diabetes in the first follow-up cohort of the Heart Disease and Diabetes Risk indicators in a Screened Cohort study (HDDRISC-1). J Int Med. 1998. 244: 33-41. https://doi.org/10.1046/j.1365-2796.1998.00312.x
  7. Hunt KJ, Heiss G, Sholinsky PD, Province MA. Familial history of metabolic disorders and the multiple metabolic syndrome: the NHLBI family heart study. Genet Epidemiol. 2000. 19: 395-409. https://doi.org/10.1002/1098-2272(200012)19:4<395::AID-GEPI10>3.0.CO;2-3
  8. Ikai E, Ishizaki M, Suzuki Y, Ishida M, Noborizaka Y, Yamada Y. Association between hepatic steatosis, insulin resistance and hyperinasulinaemia as related to hypertension in alcohol consumers and obese people. J Hum Hypert. 1995. 9: 101-105.
  9. Ishida H, Yamashita C, Kuruta Y, Yoshida Y, Noshiro M. Insulin is a dominant suppressor of sterol 12 alpha-hydroxylase P450 (CYP8B) expression in rat liver: possible role of insulin in circadian rhythm of CYP8B. J Biochem. 2000. 127: 57-64. https://doi.org/10.1093/oxfordjournals.jbchem.a022584
  10. Isomaa B, Almgren P, Tuomi T, Forse B, Lathi K, Nissen M, Taskinen MR, Groop L. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001. 24: 683-689. https://doi.org/10.2337/diacare.24.4.683
  11. Jung CH, Park JS, Lee WY, Kim SW. Original Articles: Effects of smoking, alcohol, exercise, level of education, and family history on the metabolic syndrome in Korean adults. J Kor Ore Inter Med. 2002. 63: 649-659.
  12. Korea National Statistical Office; 2008, 4.
  13. Korea National Health and Nutrition Examination Survey. 2009.
  14. Kwon HS, Park YM, Lee HJ, Lee JH, Choi YH, Ko SH, Lee JM, Kim SR, Kang SY, Lee WC, Ahn MS, Noh JH, Kang JM, Kim DC, Yoon KH, Cha BY, Lee KW, Kang SK, Son HY. The prevalence and clinical characteristics of the metabolic syndrome in middle-aged Korean adults. Kor J Med. 2005. 68: 359-368.
  15. Lee DH, Jacobs DR Jr, Gross M, Kiefe CI, Roseman J, Lewis CE, Steffes M. Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chemi. 2003. 49: 1358-1366. https://doi.org/10.1373/49.8.1358
  16. Lee SJ. Prevalence of a metabolic syndrome and analysis on it's related factors in Korea. Master's dissertation, 2007.
  17. Lim JS, Kim YJ, Choi BY, Yang JH, Lee DH, Kam S. The Association between Serum GGT Level within Normal Range and Risk Factors of Cardiovascular Diseases. J Prevent Med and Pub Heal. 2005. 38: 101-106.
  18. Lim YL, Hwang SW, Shim HJ, Oh EH, Jang YS, Jho BR. Prevalence and Risk Factors of the Metabolic Syndrome as Defined by NCEP-ATP III. J Kor Acad Fam Med. 2003. 24: 135-143.
  19. Miyake Y, Eguchi H, Shinchi K, Oda T, Sasazuki S, Kono S. Glucose intolerance and serum aminotransferase activities in Japanese men. J Hepato. 2003. 38: 18-23.
  20. Mun JH. The risk factors of metabolic syndrome and the association between metabolic syndrome. doctoral dissertation, 2004.
  21. Nakanishi N, Nishina K, Li W, Sato M, Suzuki K, Tatara K. Serum gamma-glutamyltransferase and development of impaired fasting glucose or type 2 diabetes in middle-aged Japanes men. J Interl Med. 2003. 254: 287-295. https://doi.org/10.1046/j.1365-2796.2003.01198.x
  22. Park HS, Oh SW, Kang JH, Park YW, Choi JM, Kim YS, Choi WH, You HJ, Kim HS. Prevalence and Associated Factors with Metabolic Syndrome in South Korea. Kor J Obes. 2003. 12: 1-13.
  23. Park JS, Park HD, Yoon JW, Jung CH, Lee WY, Kim SW. Prevalence of association the metabolic syndrome as defined by NCEP - APT III among the urban Korean population. Kor J Med. 2002. 63: 290-299.
  24. Perry IJ, Wannamethee SG, Shaper AG. Prospective study of serum gamma-glutamyltransferase and risk of NIDDM. Diab Care 1988. 21: 732-737.
  25. Rantala AO, Lilja M, Kauma H, Savolainen MJ, Reunanen A, Kesaniemi YA. Gamma-glutamyltranspeptidase and the metabolic syndrome. J Inter Med. 2000. 248: 230-238. https://doi.org/10.1046/j.1365-2796.2000.00723.x
  26. Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Ann Rev Med. 1993. 44: 121-131. https://doi.org/10.1146/annurev.me.44.020193.001005
  27. Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Ann Rev Med. 1993. 44: 121-131. https://doi.org/10.1146/annurev.me.44.020193.001005
  28. Szegedi A, Muller MJ, Himmerich H, Anghelescu I, Wetzel H. Carbohydrate-deficient transferrin (CDT) and HDLcholesterol (HDL) are highly correlated in male alcohol dependent patients. Alcoholism 2000. 24: 497-500. https://doi.org/10.1111/j.1530-0277.2000.tb02017.x
  29. WHO West Pacific Region. The Asia-Pacific Perspective: Redefining Obesity and its Treatment. IOTF. 2000.
  30. Yamamoto A, Temba H, Horibe H, Mabuchi H, Saito Y, Matsuzawa Y, Kita T, Nakamura H. Life style and cardiovascular risk factors in the Japanese population-from an epidemiological survey on serum lipid levels in Japan 1990 part 1: influence of life style and excess body weight on HDL-cholesterol and other lipid parameters in men. J Atheroscler Thromb. 2003. 10: 165-175. https://doi.org/10.5551/jat.10.165
  31. Yokoyama H, Hirose H, Moriya S, Saito I. Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidas (gamma-GTP) activity in non-drinkers. Alcoholism 2002. 26: 91-94.