Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
권호 표지

Effect of Cnidium officinale Mixture on Recovery Capability of DNCB-induced Allergic Contact Dermatitis in Rat

  • Lim, Jae-Hwan (Department of Biological Science, Andong National University) ;
  • Park, Young-Mi (Department of Biological Science, Andong National University) ;
  • Jeong, Hyung-Jin (Department of Medicinal Plant Resource, Andong National University) ;
  • Seo, Eul-Won (Department of Biological Science, Andong National University)
  • Received : 2011.02.07
  • Accepted : 2011.03.19
  • Published : 2011.03.31
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Abstract

This study is aimed to investigate the skin thickness, plasma components, serum IgE level and antioxidant enzymes activities by mixtures of Cnidium officinale, Saururus chinensis, Houttuynia cordata and Glycyrrhiza uralensis on the allergic contact dermatitis of rat induced by 1-chloro-2,4-dinitrochlorobenzene (DNCB). Mixtures reduced the thickness of the skin and removed the dead skin cells compared to the skin of rats treated with DNCB alone. Also, these mixtures down-regulated the contents of lipid and IgE, and reduced the activities of superoxide dismutase and catalase. These results indicate that the mixtures significantly recovered the contact dermatitis induced by DNCB. In conclusion, it is thought that the mixtures could be useful for the allergic contact dermatitis.

Keywords

References

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