Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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In Silico Study of the Ion Channel Formed by Tolaasin I Produced by Pseudomonas tolaasii

  • Jo, Geun-Hyeong (Division of Bioscience and Biotechnology, BMIC, Konkuk University) ;
  • Hwang, Do-Seok (Division of Bioscience and Biotechnology, BMIC, Konkuk University) ;
  • Lee, Sun-Hee (Division of Bioscience and Biotechnology, BMIC, Konkuk University) ;
  • Woo, Yoon-Kyung (Division of Bioscience and Biotechnology, BMIC, Konkuk University) ;
  • Hyun, Ji-Ye (Division of Bioscience and Biotechnology, BMIC, Konkuk University) ;
  • Yong, Yeon-Joong (Division of Bioscience and Biotechnology, BMIC, Konkuk University) ;
  • Kang, Kyung-Rai (Division of Bioscience and Biotechnology, BMIC, Konkuk University) ;
  • Kim, Dong-Woon (Swine Science Division, National Institute of Animal Science, RDA) ;
  • Lim, Yoong-Ho (Division of Bioscience and Biotechnology, BMIC, Konkuk University)
  • Received : 2011.03.15
  • Accepted : 2011.06.16
  • Published : 2011.10.28
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Abstract

A toxin produced by Pseudomonas tolaasii, tolaasin, causes brown blotch disease in mushrooms. Tolaasin forms pores on the cellular membrane and destroys cell structure. Inhibiting the ability of tolaasin to form ion channels may be an effective method to protect against attack by tolaasin. However, it is first necessary to elucidate the three-dimensional structure of the ion channels formed by tolaasin. In this study, the structure of the tolaasin ion channel was determined in silico based on data obtained from nuclear magnetic resonance experiments.

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References

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