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Optical Spectroscopic Analysis of Muscle Spasticity for Low-Level Laser Therapy (LLLT)

  • Lee, Yeon-Ui (Department of Biomedical Engineering, College of Medical Science, Catholic University of Daegu) ;
  • Lee, Sang-Kwan (Department of Internal Medicine and Neuroscience, College of Oriental Medicine, WonKwang University) ;
  • Youn, Jong-In (Department of Biomedical Engineering, College of Medical Science, Catholic University of Daegu)
  • 투고 : 2011.09.09
  • 심사 : 2011.11.30
  • 발행 : 2011.12.25

초록

Current therapeutic methods for suppressing muscle spasticity are intensive functional training, surgery, or pharmacological interventions. However, these methods have not been fully supported by confirmed efficacy due to the aggravation of the muscle spasticity in some patients. In this study, a combined system was developed to treat with a low-level laser and to monitor the region of the treatment using an optical spectroscopic probe that measures oxygen saturation and deoxygenation during low-level laser therapy (LLLT). The evaluation of the wavelength dependence for LLLT was performed using a Monte Carlo simulation and the results showed that the greatest amount of heat generation was seen in the deep tissue at ${\lambda}$ = 830 nm. In the oxy- and deoxygenation measurements during and after the treatment, oxygen-Hb concentration was significantly increased in the laser-irradiated group when compared to the control group. These findings suggest that LLLT using ${\lambda}$ = 830 nm may be of benefit in accelerating recovery of muscle spasticity. The combined system that we have developed can monitor the physiological condition of muscle spasticity during the laser treatment in real time and may also be applied to various myotonia conditions such as muscle fatigue, back-pain treatment/monitoring, and ulcer due to paralysis.

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참고문헌

  1. D. V. Vaz and M. C. Mancini, "Muscle stiffness and strength and their relation to hand function in children with hemiplegic cerebral palsy," Developmental Medicine & Child Neurology 48, 728-733 (2006). https://doi.org/10.1017/S0012162206001563
  2. R. L. Lieber, S. Steinman, I. A. Barash, and H. Chambers, "Structural and functional changes in spastic skeletal muscle," Muscle Nerve 29, 615-27 (2004). https://doi.org/10.1002/mus.20059
  3. R. A. Deyo, J. Bergman, and W. R. Phillips, "Drug therapy for back pain: Which drugs help which patients?," Spine 21, 2840-2850 (1996). https://doi.org/10.1097/00007632-199612150-00007
  4. R. Chou, K. Peterson, and M. Helfand, "Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal condition: a systematic review," J. Pain Symptom Manage 28, 140-175 (2004). https://doi.org/10.1016/j.jpainsymman.2004.05.002
  5. A. Hulme, W. J. MacLennan, and R. T. Ritchie, "Baclofen in the elderly stroke patient its side effects and pharmacokinetics," Eur. J. Clin. Pharmacol. 29, 467-469 (1985). https://doi.org/10.1007/BF00613463
  6. H. Mori, H. Ohsawa, T. H. Tanaka, E. Taniwaki, G. Leisman, and K. Nishijo, "Effect of massage on blood flow and muscle fatigue following isometric lumbar exercise," Med. Sci. Monit. 10, 173-178 (2004).
  7. B. Drust, G. Atkinson, W. Gregson, D. French, and D. Binningsley, "The effects of massage on intra muscular temperature in the vastus lateralis in humans," Int. J. Sports Med. 24, 395-399 (2003). https://doi.org/10.1055/s-2003-41182
  8. Y. Y Huang, A. C. Chen, J. D. Carroll, and M. R. Hamblin, "Biphasic dose response in low level light therapy," Dose Response 7, 358-383 (2009). https://doi.org/10.2203/dose-response.09-027.Hamblin
  9. D. A. Sussai, P. T. Carvalho, D. M. Dourado, A. C. Belchior, F. A. dos Reis, and D. M. Pereira, "Low-level laser therapy attenuates creatine kinase levels and apoptosis during forced swimming in rats," Lasers Med. Sci. 25, 115-120 (2009).
  10. A. R. Medrado, L. S. Pugliese, S. R. Reis, and Z. A. Andrade, "Influence of low level laser therapy on wound healing and its biological action upon myofibroblasts," Lasers Surg. Med. 32, 239-244 (2003). https://doi.org/10.1002/lsm.10126
  11. C. R. Hayworth, J. C. Rojas, E. Padilla, G. M. Holmes, E. C. Sheridan, and F. Gonzalez-Lima, "In vivo low-level light therapy increases cytochrome oxidase in skeletal muscle," Photochem. Photobiol. 86, 673-680 (2010). https://doi.org/10.1111/j.1751-1097.2010.00732.x
  12. T. Karu, "Primary and secondary mechanisms of action of visible to near-IR radiation on cells," J. Photochem. Photobiol. B: Biol. 49, 1-17 (1999). https://doi.org/10.1016/S1011-1344(98)00219-X
  13. Y. Asagai, A. Imakiire, and T. Ohshiro, "Thermographic effects of laser therapy in patients with cerebral palsy," Laser Therapy 12, 12-15 (2000). https://doi.org/10.5978/islsm.12.12
  14. E. C. Leal Junior, R. A. Lopes-Martins, F. Dalan, M. Ferrari, F. M. Sbabo, R. A. Generosi, B. M. Baroni, S. C. Penna, V. V. Iversen, and J. M. Bjordal, "Effect of 655-nm low-level laser therapy on exerciseinduced skeletal muscle fatigue in humans," Photomed. Laser Surg. 26, 419-424 (2008). https://doi.org/10.1089/pho.2007.2160
  15. J. B. Walker, "Temporary suppression of clonus in humans by brief photostimulation. Brain research," Brain Res. 340, 109-113 (1985). https://doi.org/10.1016/0006-8993(85)90779-6
  16. J. D. MacDougall, A. L. Hicks, J. R. MacDonald, R. S. Mckelvie, H. J. Green, and K. M. Smith, "Muscle performance and enzymatic adaptations to sprint interval training," J. Appl. Physiol. 84, 2138-2142 (1998). https://doi.org/10.1063/1.368275
  17. S. Ahmaidi, P. Granier, Z. Taoutaou, J. Mercier, H. Dubouchaud, and C. Prefaut, "Effects of active recovery on plasma lactate and anaerobic power following repeated intensive exercise," Med. Sci. Sports Exerc. 28, 450-456 (1996). https://doi.org/10.1097/00005768-199604000-00009
  18. T. O. McBride, B. W. Pogue, E. D. Gerety, S. B. Poplack, U. L. Osterberg, and K. D. Paulsen, "Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue," Appl. Opt. 38, 5480-5490 (1999). https://doi.org/10.1364/AO.38.005480
  19. S. Volianitis, P. Krustrup, E. Dawson, and N. H. Secher, "Arm blood flow and oxygenation on the transition from arm to combined arm and leg exercise in humans," J. Physiol. 547, 641-648 (2003). https://doi.org/10.1113/jphysiol.2002.034496
  20. M. Johns, C. A. Giller, and H. Liu, "Determination of hemoglobin oxygen saturation from turbid media using reflectance spectroscopy with small source-detector separations," Applied Spectroscopy 55, 1686-1694 (2001). https://doi.org/10.1366/0003702011954026
  21. F. Costes, F. Prieur, L. Reasson, A. Geyssant, J. C. Barthelemy, and C. Denis, "Influence of trainging on NIRS muscle oxygen saturation during submaximal exercise," Med. Sci. Sports Exercise 33, 1484-1489 (2001). https://doi.org/10.1097/00005768-200109000-00010
  22. T. Binzoni, L. Ngo, E. Hiltbrand, R. Springett, and D. Delpy, "Comsumption-temperature curves during rest and isometric exercise in human skeletal muscle," Comp. Biochem. Physiol. A 132, 27-32 (2002).
  23. T. Karu, "Primary and secondary mechanisms of action of visible to near-IR radiation on cells," J. Photochem. Photobiol. B 49, 1-17 (1999). https://doi.org/10.1016/S1011-1344(98)00219-X
  24. C. M. Carvalho, J. A. de Lacerda, F. P. dos Santos Neto, M. C. T. Cangussu, A. M. C. Marques, and A. L. B. Pinheiro, "Wavelength effect in temporomandibular joint pain : a clinical experience," Lasers Med. Sci. 25, 229-232 (2010). https://doi.org/10.1007/s10103-009-0695-y
  25. J. S. Dam, P. E. Andersen, T. Dalgaard, and P. E. Fabricius, "Determination of tissue optical properties from diffuse reflectance profiles by multivariate calibration," Appl. Opt. 37, 772-778 (1998). https://doi.org/10.1364/AO.37.000772
  26. J. I. Youn, "A comparison of wavelength dependence for laser-assisted lipolysis effect using Monte Carlo simulation," J. Opt. Soc. Korea 13, 267-271 (2009). https://doi.org/10.3807/JOSK.2009.13.2.267
  27. H. Lee, Y. U. Jeong, and K. F. Chan, "The advent of laser therapies in dermatology and urology: underlying mechanisms, recent trends, and future," J. Opt. Soc. Korea 13, 321-329 (2009). https://doi.org/10.3807/JOSK.2009.13.3.321
  28. L. Wang, S. L. Jacques, and L. Zheng, "MCML-Monte Carlo modeling of light transport in multi-layered tissues," Computer Methods and Programs in Biomedicine 47, 131-146 (1995). https://doi.org/10.1016/0169-2607(95)01640-F
  29. C. S. Enwemeka, "Attenuation and penetration depth of red 632.8 nm and invisible infrared 904 nm light in soft tissues," J. Laser Ther. 13, 95-101 (2001).
  30. A. Bozkurt, A. Rosen, H. Rosen, and B. Onaral, "A portable near infrared spectroscopy system for bedside monitoring of newborn brain," BioMedical Engineering OnLine 4, 1-11 (2005). https://doi.org/10.1186/1475-925X-4-1
  31. A. W. Subudhi, A. C. Dimmen, and R. C. Roach, "Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise," J. Appl. Physiol. 103, 177-183 (2007). https://doi.org/10.1152/japplphysiol.01460.2006
  32. G. Yu, T. Durduran, C. Zhou, and A. G. Yodh, "Timedependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies," J. Biomed. Opt. 10, 024027 (2005). https://doi.org/10.1117/1.1884603
  33. M. L. Snyder, C. Bork, B. Bourbon, and D. Trumbore, "Effect of helium-neon laser on musculoskeletal trigger points," Phys. Ther. 66, 1087-1090 (1986).
  34. S. A. Spector, J. T. Lemmer, B. M. Koffman, T. A. Fleisher, I. M. Feuerstein, B. F. Hurley, and M. C. Dalakas, "Safety and efficacy of strength training in patients with sporadic inclusion body myositis," Muscle Nerve. 20, 1242-1248 (1997). https://doi.org/10.1002/(SICI)1097-4598(199710)20:10<1242::AID-MUS6>3.0.CO;2-C
  35. R. T. Hepple, J. L. Hagen, D. J. Krause, and C. C. Jackson, "Aerobic power declines with aging in rat skeletal muscles perfused at matched convective $O_2$ delivery," J. Appl. Physiol. 94, 744-751 (2003). https://doi.org/10.1152/japplphysiol.00737.2002
  36. E. C. Leal Junior, R. A. Lopes-Martins, A. A. Vanin, B. M. Baroni, D. Grosselli, T. De Marchi, V. V. Iversen, and J. M. Bjordal, "Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans," Lasers Med. Sci. 24, 425-431 (2009). https://doi.org/10.1007/s10103-008-0592-9
  37. S. Passarella, E. Casamassima, S. Molinari, D. Pastore, E. Quagliariello, I. M. Catalano, and A. Cingolani, "Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondria irradiated in vitro by helium-neon laser," FEBS Letters 175, 95-99 (1984). https://doi.org/10.1016/0014-5793(84)80577-3
  38. T. I. Karu, "Mitochondrial signaling in mammalian cells activated by red and near-IR radiation," Photochem. Photobiol. 84, 1091-1099 (2008). https://doi.org/10.1111/j.1751-1097.2008.00394.x
  39. C. Kudoh, K. Inomata, K. Okajima, M. Motegi, and T. Ohshiro, "Low level laser therapy : pain attenuation mechanism," Laser ther. 10, 3-6 (1988).

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