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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Dimethylsulfoxide (DMSO) induces downregulation of heme oxygenase-1 (HO-1) in HL-60 cells: involvement of HO-1 in HL-60 cell differentiation

  • Noh, Eun-Mi (Department of Biochemistry, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Cho, Dong-Hyu (Department of Obstetrics & Gynecology, Chonbuk National University Medical School) ;
  • Lee, Young-Rae (Department of Biochemistry, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Jeong, Young-Ju (Department of Obstetrics & Gynecology, Chonbuk National University Medical School) ;
  • Kim, Jong-Hyeon (Department of Obstetrics & Gynecology, Chonbuk National University Medical School) ;
  • Chae, Hee-Suk (Department of Obstetrics & Gynecology, Chonbuk National University Medical School) ;
  • Park, Jinny (Division of Hematology/Oncology, Department of Internal Medicine, Gachon University of Medicine and Science, Gil Hospital) ;
  • Jung, Won-Seok (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Joo (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Kim, Jong-Suk (Department of Biochemistry, Institute for Medical Sciences, Chonbuk National University Medical School)
  • Received : 2011.09.26
  • Accepted : 2011.10.10
  • Published : 2011.11.30
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Abstract

Heme oxygenase-1 (HO-1), an inducible enzyme with broad tissue expression, is wel1-regulated in response to hematopoietic stress and preserves vascular homeostasis. We investigated the involvement of HO-1 in HL-60 cell differentiation. Dimethyl sulfoxide (DMSO) completely decreased HO-1 expression in a time-dependent manner, but clearly induced HL-60 cell differentiation, as evidenced by a marked increase in CD11b expression. Interestingly, zinc protoporphyrin (ZnPP), a strong inhibitor of HO-1, induced HL-60 cell differentiation. In contrast, treatment with cobalt protoporphyrin (CoPP), an activator of HO-1, decreased CD11b expression. Additionally, ZnPP down-regulated HO-1 protein expression in HL-60 cells, whereas CoPP induced upregulation. These results suggest that HO-1 might have a negative function in DMSO-induced HL-60 cell differentiation. This study provides the first evidence that HO-1 plays an important role in DMSO-induced HL-60 cell differentiation.

Keywords

References

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