Korean Circulation Journal

  • 제40권11호
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  • Pages.604-608
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  • 2010
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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A Case of Chloroquine-Induced Cardiomyopathy That Presented as Sick Sinus Syndrome

  • Lee, Jae-Hak (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Chung, Woo-Baek (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kang, Ju-Hyun (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Hyung-Woo (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Jin-Jin (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Ji-Hyun (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Hwang, Hui-Jeong (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Lee, Jea-Beom (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Chung, Jong-Won (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Hyo-Lim (Department of Internal Medicine and Radiology, College of Medicine, The Catholic University of Korea) ;
  • Choi, Yun-Seok (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Park, Chul-Soo (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Youn, Ho-Joong (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Lee, Man-Young (Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea)
  • 투고 : 2010.02.09
  • 심사 : 2010.04.02
  • 발행 : 2010.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

A 52-year-old woman with rheumatoid arthritis who had been treated with prednisone and hydroxychloroquine for >12 years presented with chest discomfort and a seizure. She was diagnosed with restrictive cardiomyopathy combined with sick sinus syndrome. A myocardial muscle biopsy was performed to identify the underlying cardiomyopathy, which showed marked muscle fiber hypertrophy, fiber dropout, slightly increased interstitial fibrous connective tissue, and extensive cytoplasmic vacuolization of the myocytes under light microscopy. Electron microscopy of the myocytes demonstrated dense, myeloid, and curvilinear bodies. The diagnosis of hydroxychloroquine-induced cardiomyopathy was made based on the clinical, hemodynamic, and pathologic findings. This is the first case report describing chloroquine-induced cardiomyopathy involving the heart conduction system.

키워드

참고문헌

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피인용 문헌

  1. Cardiomyopathy Caused by Longterm Treatment with Chloroquine: A Rare Disease, or a Rare Diagnosis? vol.39, pp.5, 2010, https://doi.org/10.3899/jrheum.110959
  2. Hydroxychloroquine-Induced Cardiomyopathy That Presented as Pulmonary Hypertension: A Newly Noted Complication vol.123, pp.3, 2010, https://doi.org/10.1159/000343142
  3. Chloroquine cardiomyopathy - a review of the literature vol.35, pp.3, 2010, https://doi.org/10.3109/08923973.2013.780078
  4. Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy: key diagnostic features and literature review vol.2, pp.1, 2010, https://doi.org/10.1177/2048872612471215
  5. Restrictive Cardiomyopathy Associated With Long-Term Use of Hydroxychloroquine for Systemic Lupus Erythematosus vol.30, pp.5, 2010, https://doi.org/10.1177/0897190016655726
  6. Antimalarial-induced cardiomyopathy: a systematic review of the literature vol.27, pp.4, 2010, https://doi.org/10.1177/0961203317734922
  7. Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature vol.41, pp.10, 2010, https://doi.org/10.1007/s40264-018-0689-4
  8. Antimalarial-induced Cardiomyopathy in Systemic Lupus Erythematosus: As Rare as Considered? vol.46, pp.4, 2019, https://doi.org/10.3899/jrheum.180124