Korean Circulation Journal

  • 제40권11호
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  • Pages.581-586
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  • 2010
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
권호 표지
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Comparison of Plaque Composition in Diabetic and Non-Diabetic Patients With Coronary Artery Disease Using Multislice CT Angiography

  • Kwon, Yong-Seop (Department of Internal Medicine, Busan St. Mary's Hospital) ;
  • Jang, Jae-Sik (Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital) ;
  • Lee, Chang-Won (Department of Internal Medicine, Busan St. Mary's Hospital) ;
  • Kim, Dong-Kie (Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital) ;
  • Kim, Ung (Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital) ;
  • Seol, Sang-Hoon (Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital) ;
  • Kim, Doo-Il (Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital) ;
  • Jo, Young-Wan (Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital) ;
  • Jin, Han-Young (Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital) ;
  • Seo, Jeong-Sook (Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital) ;
  • Yang, Tae-Hyun (Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital) ;
  • Kim, Dae-Kyeong (Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital) ;
  • Kim, Dong-Soo (Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital)
  • 투고 : 2010.03.12
  • 심사 : 2010.05.11
  • 발행 : 2010.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: Plaque composition rather than degree of luminal narrowing may be predictive of future coronary events in high risk patients. The purpose of this study was to compare degree of plaque burden and composition with mul-tislice computed tomography (MSCT) angiography between diabetic and non-diabetic patients. Subjects and Methods: A total of 452 consecutive MSCT angiography examinations were performed between July 2007 and June 2009. Of these, the patients who underwent invasive coronary angiography were evaluated for the presence and type of atherosclerotic plaque and severity of luminal narrowing. Results: Ninety two (46 in the diabetic group and 46 in the non-diabetic group) patients underwent both MSCT angiography and invasive coronary angiography. Among them, 30 patients (65.2%) in the diabetic group and 26 patients (56.5%) in the non-diabetic group had significant coronary narrowing on MSCT angiography. Sixteen patients (34.8%) in the diabetic group and 15 patients (32.6%) in non-diabetic group underwent coronary angioplasty and stenting. Forty-two patients (93.3%) in the diabetic group and 39 patients (88.6%) in the non-diabetic group had multiple types of coronary plaque (p=0.485). MSCT angiography was similar to conventional coronary angiography in its ability to predict significant coronary artery disease in that the area under the curve was 0.88 (95% confidence interval, 0.81 to 0.95). Diabetic patients had more mixed plaque compared with non-diabetic patients. Conclusion: Differences in coronary plaque composition between diabetic and non-diabetic patients can be determined noninvasively by MSCT angiography. In patients with diabetes, mixed plaque types contribute to the total plaque burden to a higher degree than in non-diabetic patients.

키워드

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피인용 문헌

  1. Impact of diabetes on 10-year outcomes of patients with multivessel coronary artery disease in the Medicine, Angioplasty, or Surgery Study II (MASS II) trial vol.166, pp.2, 2010, https://doi.org/10.1016/j.ahj.2013.04.017
  2. Coronary computed tomography angiography as a tool for long-term cardiovascular risk stratification in diabetic patients vol.34, pp.7, 2019, https://doi.org/10.1007/s00380-018-01339-0