Korean Circulation Journal

  • 제40권11호
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  • Pages.573-580
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  • 2010
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Bone Mineral Density is an Independent Determinant of Left Ventricular Mass Index in the General Female Population

  • Lim, Young-Hyo (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Shin, Jin-Ho (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Lee, Jae-Ung (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Lim, Heon-Kil (Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Hong, Sang-Mo (Division of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Mi-Kyung (Department of Preventive Medicine, Hanyang University College of Medicine) ;
  • Choi, Bo-Youl (Department of Preventive Medicine, Hanyang University College of Medicine) ;
  • Kim, Yu-Mi (Department of Preventive Medicine, Dong-A University College of Medicine)
  • 투고 : 2010.03.12
  • 심사 : 2010.05.12
  • 발행 : 2010.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: Left ventricular hypertrophy (LVH) is a well known cardiovascular prognostic predictor. Osteoporosis has been suggested to be associated with cardiovascular disease. According to studies of primary hyperparathyroidism, a pathophysiological association between calcium metabolism and LVH has been suggested but is not yet fully understood. This study was performed to investigate the association between bone mineral density (BMD) and left ventricular mass index (LVMI) in a general population. Subjects and Methods: Data from 460 subjects among 543 subjects sampled from a general population in a rural area in Korea were analyzed. BMD, echocardiography, brachial-ankle pulse wave velocity (ba-PWV), carotid intima-media thickness (IMT) measurement as well as the measurements of blood pressure, blood chemistry and metabolic parameters were analyzed. BMD was measured using the Sahara Clinical Bone Sonometer (Hologic Inc., Mass., USA). Results: Age of the subjects was 59.4${\pm}$12.4 years. Males were 42.2% (n=194). In a simple correlation analysis on female subjects, age and waist circumference showed negative correlation, and body mass index (BMI) showed positive correlation with BMD. However, only age showed negative correlation with BMD in male subjects. After adjusting baPWV and carotid IMT, we found that BMD was an independent determinant of LVMI in female subjects (${\beta}$=-13.703, p=0.016), but not in male subjects (${\beta}$=-1.235, p=0.841). Conclusion: BMD is a consistent and independent determining factor of LVMI, BMI and carotid IMT in postmenopausal women.

키워드

참고문헌

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  2. Bone mineral density is associated with left ventricular diastolic function in women : BMD and LV diastolic dysfunction in women vol.39, pp.12, 2016, https://doi.org/10.1002/clc.22592
  3. Associations between hip bone mineral density, aortic calcification and cardiac workload in community-dwelling older Australians vol.28, pp.7, 2010, https://doi.org/10.1007/s00198-017-4024-1
  4. Identification of hub genes associated with postmenopausal osteoporosis by Gibbs sampling method vol.17, pp.4, 2019, https://doi.org/10.3892/etm.2019.7231