Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Relationship Between Obesity and N-Terminal Brain Natriuretic Peptide Level as a Prognostic Value After Acute Myocardial Infarction

  • Choi, Seon-Gyu (Department of Internal Medicine, Yeosu Chonnam Hospital) ;
  • Jeong, Myung-Ho (Department of Internal Medicine, The Heart Center of Chonnam National University Hospital) ;
  • Ahn, Young-Keun (Department of Internal Medicine, The Heart Center of Chonnam National University Hospital) ;
  • Cho, Jeong-Gwan (Department of Internal Medicine, The Heart Center of Chonnam National University Hospital) ;
  • Kang, Jung-Chaee (Department of Internal Medicine, The Heart Center of Chonnam National University Hospital) ;
  • Chae, Shung-Chull (Department of Internal Medicine, Kyungpook National University College of Medicine) ;
  • Hur, Seung-Ho (Department of Internal Medicine, Keimyung University College of Medicine) ;
  • Hong, Taek-Jong (Department of Internal Medicine, Pusan National University Schoool of Medicine) ;
  • Kim, Young-Jo (Department of Internal Medicine, Yeungnam University College of Medicine) ;
  • Seong, In-Whan (Department of Internal Medicine, Chungnam National University College of Medicine) ;
  • Chae, Jei-Keon (Department of Internal Medicine, Chonbuk National University College of Medicine) ;
  • Rhew, Jay-Young (Department of Internal Medicine, Jeonju Presbyterian Medical Center) ;
  • Chae, In-Ho (Department of Internal Medicine, Seoul National University College of Medicine) ;
  • Cho, Myeong-Chan (Department of Internal Medicine, Chungbuk National College of Medicine) ;
  • Bae, Jang-Ho (Department of Internal Medicine, Konyang University College of Medicine) ;
  • Rha, Seung-Woon (Department of Internal Medicine, Korea University College of Medicine) ;
  • Kim, Chong-Jin (Department of Internal Medicine, Kyunghee University College of Medicine) ;
  • Choi, Dong-Hoon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Jang, Yang-Soo (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Yoon, Jung-Han (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Chung, Wook-Sung (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Seung, Ki-Bae (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Park, Seung-Jung (Department of Internal Medicine, University of Ulsan College of Medicine)
  • Received : 2010.01.22
  • Accepted : 2010.04.13
  • Published : 2010.11.30
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Abstract

Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393${\pm}$4,022 pg/mL in the lean group (n=875), 1,506${\pm}$3,074 pg/mL in the overweight group (n=724) and 1,100${\pm}$1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.

Keywords

References

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