DOI QR코드

DOI QR Code

Current Concepts in Cardiac CT Angiography for Patients With Acute Chest Pain

  • Yoo, Seung-Min (Department of Diagnostic Radiology, CHA Medical University Hospital, Chung-Ang University College of Medicine) ;
  • Rho, Ji-Young (Department of Diagnostic Radiology, CHA Medical University Hospital, Chung-Ang University College of Medicine) ;
  • Lee, Hwa-Yeon (Department of Diagnostic Radiology, Chung-Ang University College of Medicine) ;
  • Song, In-Sup (Department of Diagnostic Radiology, Chung-Ang University College of Medicine) ;
  • Moon, Jae-Youn (Department of Cardiology, CHA Medical University Hospital, Chung-Ang University College of Medicine) ;
  • White, Charles S. (Department of Diagnostic Radiology, University of Maryland)
  • Published : 2010.11.30

Abstract

This article presents specific examples of delayed diagnosis of acute coronary syndrome, acute aortic dissection, and pulmonary embolism resulting from evaluating patients with nonspecific acute chest pain who did not undergo immediate dedicated coronary CT angiography (CTA) or triple rule-out protocol (TRO). These concrete examples of delayed diagnosis may advance the concept of using cardiac CTA (i.e., dedicated coronary CTA versus TRO) to triage patients with nonspecific acute chest pain. This article also provides an overall understanding of how to choose the most appropriate examination based on the specific clinical situation in the emergency department (i.e., dedicated coronary CTA versus TRO versus dedicated pulmonary or aortic CTA), how to interpret the CTA results, and the pros and cons of biphasic versus triphasic administration of intravenous contrast material during TRO examination. A precise understanding of various cardiac CTA protocols will improve the diagnostic performance of radiologists while minimizing hazards related to radiation exposure and contrast use.

Keywords

References

  1. Bastarrika G, Thilo C, Headden GF, Zwerner PL, Costello P, Schoepf UJ. Cardiac CT in the assessment of acute chest pain in the emergency department. AJR Am J Roentgenol 2009;193:397-409. https://doi.org/10.2214/AJR.08.2265
  2. Lee HY, Yoo SM, White CS. Coronary CT angiography in emergency department patients with acute chest pain: triple rule-out protocol versus dedicated coronary CT angiography. Int J Cardiovasc Imaging 2009;25:319-26. https://doi.org/10.1007/s10554-008-9375-4
  3. Halpern EJ. Triple rule-out CT angiography for evaluation of acute chest pain and possible acute coronary syndrome. Radiology 2009;252:332-45. https://doi.org/10.1148/radiol.2522082335
  4. Johnson TR, Nikolaou K, Wintersperger BJ, et al. Optimization of contrast material administration for electrocardiogram-gated computed tomographic angiography of the chest. J Comput Assist Tomogr 2007;31:265-71. https://doi.org/10.1097/01.rct.0000236421.35761.7a
  5. Frauenfelder T, Appenzeller P, Karlo C, et al. Triple rule-out CT in the emergency department: protocols and spectrum of imaging findings. Eur Radiol 2009;19:789-99. https://doi.org/10.1007/s00330-008-1231-3
  6. Litmanovich D, Zamboni GA, Hauser TH, Lin PJ, Clouse ME, Raptopoulos V. ECG-gated chest CT angiography with 64-MDCT and triphasic IV contrast administration regimen in patients with acute non-specific chest pain. Eur Radiol 2008;18:308-17. https://doi.org/10.1007/s00330-007-0739-2
  7. Shuman WP, Branch KR, May JM, et al. Whole-chest 64-MDCT of emergency department patients with nonspecific chest pain: radiation dose and coronary artery image quality with prospective ECG triggering versus retrospective ECG gating. AJR Am J Roentgenol 2009;192:1662-7. https://doi.org/10.2214/AJR.08.1872
  8. Johnson TR, Nikolaou K, Becker A, et al. Dual-source CT for chest pain assessment. Eur Radiol 2008;18:773-80. https://doi.org/10.1007/s00330-007-0803-y
  9. Schertler T, Scheffel H, Frauenfelder T, et al. Dual-source computed tomography in patients with acute chest pain: feasibility and image quality. Eur Radiol 2007;17:3179-88. https://doi.org/10.1007/s00330-007-0724-9
  10. Takakuwa KM, Halpern EJ. Evaluation of a "triple rule-out" coronary CT angiography protocol: use of 64-Section CT in low-to-moderate risk emergency department patients suspected of having acute coronary syndrome. Radiology 2008;248:438-46. https://doi.org/10.1148/radiol.2482072169
  11. Pozen MW, D'Agostino RB, Selker HP, Sytkowski PA, Hood WB Jr. A predictive instrument to improve coronary-care-unit admission practices in acute ischemic heart disease. A prospective multicenter clinical trial. N Engl J Med 1984;310:1273-8. https://doi.org/10.1056/NEJM198405173102001
  12. Hagan PG, Nienaber CA, Isselbacher EM, et al. The International Rregistry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA 2000;283:897-903. https://doi.org/10.1001/jama.283.7.897
  13. Abcarian PW, Sweet JD, Watabe JT, Yoon HC. Role of a quantitative D-dimer assay in determining the need for CT angiography of acute pulmonary embolism. AJR Am J Roentgenol 2004;182:1377-81. https://doi.org/10.2214/ajr.182.6.1821377
  14. Klompas M. Does this patient have an acute thoracic aortic dissection? JAMA 2002;287:2262-72. https://doi.org/10.1001/jama.287.17.2262
  15. Viljanen T. Diagnostic difficulties in aortic dissection. Retrospective study of 89 surgically treated patients. Ann Chir Gynaecol 1986;75:328-32.
  16. Rogg JG, Neve JW, Huang C, et al. The triple work-up for emergency department patients with acute chest pain: how often does it occur? J Emerg Med 2008. [Epub ahead of print]
  17. van Belle A, Buller HR, Huisman MV, et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA 2006;295:172-9. https://doi.org/10.1001/jama.295.2.172
  18. von Kodolitsch Y, Schwartz AG, Nienaber CA. Clinical prediction of acute aortic dissection. Arch Intern Med 2000;160:2977-82. https://doi.org/10.1001/archinte.160.19.2977
  19. Gallagher MJ, Raff GL. Use of multislice CT for the evaluation of emergency room patients with chest pain: the so-called "triple rule-out". Catheter Cardiovasc Interv 2008;71:92-9. https://doi.org/10.1002/ccd.21398
  20. Pannu HK, Alvarez W Jr, Fishman EK. Beta-blockers for cardiac CT: a primer for the radiologist. AJR Am J Roentgenol 2006;186(6 Suppl 2):S341-5. https://doi.org/10.2214/AJR.04.1944
  21. Hoffmann U, Bamberg F, Chae CU, et al. Coronary computed tomography angiography for early triage of patients with acute chest pain: the ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) trial. J Am Coll Cardiol 2009;53:1642-50. https://doi.org/10.1016/j.jacc.2009.01.052
  22. Hamon M, Biondi-Zoccai GC, Malagutti P, et al. Diagnostic performance of multislice spiral computed tomography of coronary arteries as compared with conventional invasive coronary angiography: a meta-analysis. J Am Coll Cardiol 2006;48:1896-910. https://doi.org/10.1016/j.jacc.2006.08.028
  23. Dokainish H, Pillai M, Murphy SA, et al. Prognostic implications of elevated troponin in patients with suspected acute coronary syndrome but no critical epicardial coronary disease: a TACTICS-TIMI-18 substudy. J Am Coll Cardiol 2005;45:19-24. https://doi.org/10.1016/j.jacc.2004.09.056
  24. Patel MR, Chen AY, Peterson ED, et al. Prevalence, predictors, and outcomes of patients with non-ST-segment elevation myocardial infarction and insignificant coronary disease: results from the can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines (CRUSADE) initiative. Am Heart J 2006;152:641-7. https://doi.org/10.1016/j.ahj.2006.02.035
  25. Goldstein JA, Gallagher MJ, O'Neill WW, Ross MA, O'Neil BJ, Raff GL. A randomized controlled trial of multi-slice coronary computed tomography for evaluation of acute chest pain. J Am Coll Cardiol 2007;49:863-71. https://doi.org/10.1016/j.jacc.2006.08.064
  26. Fleischmann D, Lin M. Contrast medium utilization. In: Remy-Jardin M, Remy J, editors. Integrated Cardiothoracic Imaging with MDCT. Berlin, Germany: Springer;2008. p.53-63.
  27. Jakobs TF, Becker CR, Ohnesorge B, et al. Multislice helical CT of the heart with retrospective ECG gating: reduction of radiation exposure by ECG-controlled tube current modulation. Eur Radiol 2002;12:1081-6. https://doi.org/10.1007/s00330-001-1278-x
  28. Poll LW, Cohnen M, Brachten S, Ewen K, Modder U. Dose reduction in multi-slice CT of the heart by use of ECG-controlled tube current modulation ("ECG pulsing"): phantom measurements. Rofo 2002;174:1500-5. https://doi.org/10.1055/s-2002-35945
  29. Husmann L, Valenta I, Gaemperli O, et al. Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gating. Eur Heart J 2008;29:191-7.
  30. Stolzmann P, Scheffel H, Schertler T, et al. Radiation dose estimates in dual-source computed tomography coronary angiography. Eur Radiol 2008;18:592-9. https://doi.org/10.1007/s00330-007-0786-8
  31. Scheffel H, Alkadhi H, Leschka S, et al. Low-dose CT coronary angiography in the step-and-shoot mode: diagnostic performance. Heart 2008;94:1132-7. https://doi.org/10.1136/hrt.2008.149971
  32. Hirai N, Horiguchi J, Fujioka C, et al. Prospective versus retrospective ECG-gated 64-detector coronary CT angiography: assessment of image quality, stenosis, and radiation dose. Radiology 2008;248:424-30. https://doi.org/10.1148/radiol.2482071804
  33. Ketelsen D, Luetkhoff MH, Thomas C, et al. Estimation of the radiation exposure of a chest pain protocol with ECG-gating in dual-source computed tomography. Eur Radiol 2009;19:37-41. https://doi.org/10.1007/s00330-008-1109-4

Cited by

  1. Little impact of tsunami-stricken nuclear accident on awareness of radiation dose of cardiac computed tomography: A questionnaire study vol.6, pp.None, 2010, https://doi.org/10.1186/1756-0500-6-170
  2. Modern diagnostics for type B aortic dissection vol.20, pp.6, 2015, https://doi.org/10.1007/s00772-015-0078-6
  3. Prevalence of Acute Coronary Syndrome in Patients Suspected for Pulmonary Embolism or Acute Aortic Syndrome: Rationale for the Triple Rule-Out Concept vol.7, pp.8, 2010, https://doi.org/10.14740/jocmr2197w
  4. Computed Tomography Diagnosis of Nonspecific Acute Chest Pain in the Emergency Department: From Typical Acute Coronary Syndrome to Various Unusual Mimics vol.32, pp.1, 2010, https://doi.org/10.1097/rti.0000000000000241
  5. The Expanding Role of Computed Tomography Angiography in the Evaluation of Atherosclerotic Coronary Artery Disease vol.77, pp.6, 2017, https://doi.org/10.3348/jksr.2017.77.6.353
  6. Computed Tomographic Angiography for Risk Stratification in Patients with Acute Chest Pain - The Triple Rule-out Concept in the Emergency Department vol.16, pp.2, 2020, https://doi.org/10.2174/1573405614666180604095120
  7. Current Role of Computed Tomography in the Evaluation of Acute Coronary Syndrome vol.11, pp.2, 2010, https://doi.org/10.3390/diagnostics11020266
  8. Diagnostic Accuracy of Coronary Artery Occlusion and Myocardial Perfusion Defect on Non-Gated Enhanced Chest CT in Predicting Acute Myocardial Infarction vol.7, pp.4, 2021, https://doi.org/10.3390/tomography7040043