Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Prenatal Diagnosis of Bilateral Pulmonary Agenesis: a Case Report

  • Lee, Kyung-A (Department of Obstetrics and Gynecology, Seoul National University College of Medicine) ;
  • Cho, Jeong-Yeon (Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine) ;
  • Lee, Seung-Mi (Department of Obstetrics and Gynecology, Seoul National University College of Medicine) ;
  • Jun, Jong-Kwan (Department of Obstetrics and Gynecology, Seoul National University College of Medicine) ;
  • Kang, Jieun (Department of Pathology, Seoul National University College of Medicine) ;
  • Seo, Jeong-Wook (Department of Pathology, Seoul National University College of Medicine)
  • Received : 2009.05.19
  • Accepted : 2009.07.08
  • Published : 2010.02.01
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Abstract

We report a case of bilateral pulmonary agenesis (BPA), which was suspected during a prenatal US examination and diagnosed by fetal magnetic resonance imaging (MRI). BPA is an extremely rare congenital anomaly and, although many fetal structural defects can be detected with a high degree of confidence after introducing high-resolution US, the prenatal diagnosis of BPA remains problematic. Other thoracic abnormalities, such as a congenital diaphragmatic hernia, congenital cystic adenomatoid malformation, and pulmonary sequestration, should be excluded from the list of possible diagnoses before coming to the conclusion of BPA, because BPA is absolutely incompatible with extrauterine life, and an accurate internal diagnosis can prevent a futile intervention from being performed.

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References

  1. Engellenner W, Kaplan C, Van de Vegte GL. Pulmonary agenesis association with nonimmune hydrops. Pediatr Pathol 1989;9:725-730 https://doi.org/10.3109/15513818909022379
  2. Vettraino IM, Tawil A, Comstock CH. Bilateral pulmonary agenesis: prenatal sonographic appearance simulates diaphragmatic hernia. J Ultrasound Med 2003;22:723-726 https://doi.org/10.7863/jum.2003.22.7.723
  3. Nazir Z, Qazi SH, Ahmed N, Atiq M, Billoo AG. Pulmonary agenesis-vascular airway compression and gastroesophageal reflux influence outcome. J Pediatr Surg 2006;41:1165-1169 https://doi.org/10.1016/j.jpedsurg.2006.02.012
  4. Lee EY, Boiselle PM, Cleveland RH. Multidetector CT evaluation of congenital lung anomalies. Radiology 2008;247:632-648 https://doi.org/10.1148/radiol.2473062124
  5. Laudy JA, Wladimiroff JW. The fetal lung. 1: Developmental aspects. Ultrasound Obstet Gynecol 2000;16:284-290 https://doi.org/10.1046/j.1469-0705.2000.00228.x
  6. Gabarre JA, Galindo Izquierdo A, Rasero Ponferrada M, Orbea Gallardo C, Puente Agueda JM, de la Fuente Pe′rez P. Isolated unilateral pulmonary agenesis: early prenatal diagnosis and long-term follow-up. J Ultrasound Med 2005;24:865-868 https://doi.org/10.7863/jum.2005.24.6.865
  7. Joshi S, Kotecha S. Lung growth and development. Early Hum Dev 2007;83:789-794 https://doi.org/10.1016/j.earlhumdev.2007.09.007
  8. Moreno-Alvarez O, Hernandez-Andrade E, Oros D, Jani J, Deprest J, Gratacos E. Association between intrapulmonary arterial Doppler parameters and degree of lung growth as measured by lung-to-head ratio in fetuses with congenital diaphragmatic hernia. Ultrasound Obstet Gynecol 2008;31:164-170 https://doi.org/10.1002/uog.5201
  9. Kalache KD, Chaoui R, Paris S, Bollmann R. Prenatal diagnosis of right lung agenesis using color Doppler and magnetic resonance imaging. Fetal Diagn Ther 1997;12:360-362 https://doi.org/10.1159/000264506
  10. Levine D, Barnewolt CE, Mehta TS, Trop I, Estroff J, Wong G. Fetal thoracic abnormalities: MR imaging. Radiology 2003;228:379-388 https://doi.org/10.1148/radiol.2282020604
  11. Obenauer S, Maestre LA. Fetal MRI of lung hypoplasia: imaging findings. Clin Imaging 2008;32:48-50 https://doi.org/10.1016/j.clinimag.2007.08.019
  12. Yang JI. Left diaphragmatic eventration diagnosed as congenital diaphragmatic hernia by prenatal sonography. J Clin Ultrasound 2003;31:214-217 https://doi.org/10.1002/jcu.10157
  13. Jeanty C, Nien JK, Espinoza J, Kusanovic JP, Goncalves LF, Qureshi F, et al. Pleural and pericardial effusion: a potential ultrasonographic marker for the prenatal differential diagnosis between congenital diaphragmatic eventration and congenital diaphragmatic hernia. Ultrasound Obstet Gynecol 2007;29:378-387 https://doi.org/10.1002/uog.3958

Cited by

  1. Recurrent prenatally diagnosed isolated bilateral pulmonary agenesis vol.40, pp.6, 2012, https://doi.org/10.1002/uog.11146
  2. Usefulness of ultrasonography and MRI for diagnosis of fetal pulmonary agenesis: case report and review of the literature vol.40, pp.2, 2013, https://doi.org/10.1007/s10396-012-0410-7
  3. Bilateral Pulmonary Agenesis: A Rare and Unexpected Finding in a Newborn vol.6, pp.2, 2010, https://doi.org/10.1055/s-0036-1584530