The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Usual Dose of Simvastatin Does Not Inhibit Plaque Progression and Lumen Loss at the Peri-Stent Reference Segments after Bare-Metal Stent Implantation: A Serial Intravascular Ultrasound Analysis

  • Hong, Young-Joon (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Jeong, Myung-Ho (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Choi, Yun-Ha (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Ma, Eun-Hye (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Ko, Jum-Suk (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Lee, Min-Goo (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Park, Keun-Ho (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Sim, Doo-Sun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Yoon, Nam-Sik (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Youn, Hyun-Ju (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kim, Kye-Hun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Park, Hyung-Wook (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kim, Ju-Han (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Ahn, Young-Keun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Cho, Jeong-Gwan (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Park, Jong-Chun (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences) ;
  • Kang, Jung-Chaee (The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences)
  • Received : 2010.01.25
  • Accepted : 2010.06.11
  • Published : 2010.12.01
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Abstract

Background/Aims: The aim of this study was to assess the effects of a usual dose of simvastatin (20 mg/day) on plaque regression and vascular remodeling at the peri-stent reference segments after bare-metal stent implantation. Methods: We retrospectively investigated serial intravascular ultrasound (IVUS) findings in 380 peri-stent reference segments (184 proximal and 196 distal to the stent) in 196 patients (simvastatin group, n = 132 vs. nonstatin group, n = 64). Quantitative volumetric IVUS analysis was performed in 5-mm vessel segments proximal and distal to the stent. Results: IVUS follow-up was performed at a mean of 9.4 months after stenting (range, 5 to 19 months). No significant differences were observed in the changes in mean plaque plus media (P&M) area, mean lumen area, and mean external elastic membrane (EEM) area from post-stenting to follow-up at both proximal and distal edges between the simvastatin and non-statin group. Although lumen loss within the first 3 mm from each stent edge was primarily due to an increase in P&M area rather than a change in EEM area, and lumen loss beyond 3 mm from each stent edge was due to a combination of increased P&M area and decreased EEM area, no significant differences in changes were observed in P&M, EEM, and lumen area at every 1-mm subsegment between the simvastatin and non-statin group. Conclusions: A usual dose of simvastatin does not inhibit plaque progression and lumen loss and does not affect vascular remodeling in peri-stent reference segments in patients undergoing bare-metal stent implantation.

Keywords

References

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