The Korean journal of internal medicine

  • 제25권3호
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  • Pages.337-340
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  • 2010
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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High-Dose Fentanyl Patch for Cancer Pain of a Patient with Cholangiocarcinoma

  • Kim, Jung-Han (Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine) ;
  • Kim, Mi (Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine) ;
  • Sung, Chong-Won (Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine) ;
  • Kim, Hyeoung-Su (Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine) ;
  • Jang, Hyun-Joo (Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine) ;
  • Shin, Young-Chul (Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine) ;
  • Jung, Joo-Young (Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine)
  • 투고 : 2007.07.31
  • 심사 : 2007.10.16
  • 발행 : 2010.09.01
⟨ 이전 논문 다음 논문 ⟩

초록

We describe here a patient who obtained a good analgesic effect with high-dose fentanyl patches for controlling cancer pain. A 52-year-old man was referred to our hospital because of severe cancer pain that was 7/10 on a numeric rating scale (NRS). He had been diagnosed with locally advanced cholangiocarcinoma 3 months previously. We prescribed weak opioids and an antidepressant, but his pain was not relieved. We introduced strong opioids (transdermal fentanyl patches for the background pain and a short-acting opioid for the breakthrough pain) and his pain was tolerable on 250 ${\mu}g$/hr of fentanyl patches for 3 months. With time, however, his pain intensity became worse and this reached up to 8/10 to 9/10 on the NRS. Percutaneous transhepatic biliary drainage was performed, which did not relieve his pain. We increased gradually the dose of transdermal fentanyl to 1,050 ${\mu}g$/hr (20 patches). At this dose, the patient was mentally alert, with good pain control (NRS 2/10 to 3/10) and no exacerbation of side effects. To the best of our knowledge, we report here on the highest dose of transdermal fentanyl that has been successfully used for treating a patient suffering from visceral cancer pain.

키워드

참고문헌

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피인용 문헌

  1. Efficacy of Fentanyl Transdermal Patch in the Treatment of Chronic Soft Tissue Cancer Pain vol.5, pp.1, 2010, https://doi.org/10.5812/aapm.22900
  2. Characterization of QTLs and Candidate Genes for Days to Heading in Rice Recombinant Inbred Lines vol.11, pp.9, 2020, https://doi.org/10.3390/genes11090957