DOI QR코드

DOI QR Code

Familial Clustering of Type 2 Diabetes in Korean Women with Gestational Diabetes Mellitus

  • Rhee, Sang-Youl (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine) ;
  • Kim, Joo-Young (Department of Internal Medicine, Dongsuwon Hospital) ;
  • Woo, Jeong-Taek (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine) ;
  • Kim, Young-Seol (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine) ;
  • Kim, Sung-Hoon (Division of Endocrinology and Metabolism, Department of Medicine, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine)
  • Received : 2010.03.03
  • Accepted : 2010.05.24
  • Published : 2010.09.01

Abstract

Background/Aims: This study was conducted to examine the relationship between family history of type 2 diabetes (T2DM) and risk of developing gestational diabetes mellitus (GDM) in Korean women. Methods: We performed a 100-g oral glucose tolerance test in 858 pregnant women who had abnormal glucose tolerance in 50-g oral glucose challenge. In addition, we reviewed the incidence of T2DM in the parents and siblings and analyzed the association between the familial history of T2DM and the risk of GDM. Results: Of the 858 subjects, 427 were normal, and 431 were diagnosed with GDM. Compared with women with no family history of T2DM, women with first degree family history of T2DM displayed higher risk of T2DM (odd ratio: parent only 1.91, sibling only 6.24, any 2.27). Conclusions: The risk of developing GDM was significantly increased in Korean women with a family history of T2DM in first-degree relatives.

Keywords

References

  1. Kjos SL, Buchanan TA. Gestational diabetes mellitus. N Engl J Med 1999;341:1749-1756. https://doi.org/10.1056/NEJM199912023412307
  2. Buchanan TA, Xiang AH. Gestational diabetes mellitus. J Clin Invest 2005;115:485-491.
  3. Solomon CG, Willett WC, Carey VJ, et al. A prospective study of pregravid determinants of gestational diabetes mellitus. JAMA 1997;278:1078-1083. https://doi.org/10.1001/jama.278.13.1078
  4. Retnakaran R, Connelly PW, Sermer M, Zinman B, Hanley AJ. The impact of family history of diabetes on risk factors for gestational diabetes. Clin Endocrinol (Oxf) 2007;67:754-760. https://doi.org/10.1111/j.1365-2265.2007.02958.x
  5. Williams MA, Qiu C, Dempsey JC, Luthy DA. Familial aggregation of type 2 diabetes and chronic hypertension in women with gestational diabetes mellitus. J Reprod Med 2003;48:955-962.
  6. Jang HC, Cho NH, Jung KB, Oh KS, Dooley SL, Metzger BE. Screening for gestational diabetes mellitus in Korea. Int J Gynaecol Obstet 1995;51:115-122. https://doi.org/10.1016/0020-7292(95)02524-G
  7. Coustan DR, Carpenter MW. The diagnosis of gestational diabetes. Diabetes Care 1998;21 Suppl 2:B5-B8.
  8. McLellan JA, Barrow BA, Levy JC, et al. Prevalence of diabetes mellitus and impaired glucose tolerance in parents of women with gestational diabetes. Diabetologia 1995;38:693-698. https://doi.org/10.1007/BF00401841
  9. Martin AO, Simpson JL, Ober C, Freinkel N. Frequency of diabetes mellitus in mothers of probands with gestational diabetes: possible maternal influence on the predisposition to gestational diabetes. Am J Obstet Gynecol 1985;151:471-475.
  10. Moses R, Rodda M, Griffiths R. Predominance of a maternal history of diabetes for patients with non-insulin-dependent diabetes mellitus. Implications for the intrauterine transmission of diabetes. Aust N Z J Obstet Gynaecol 1997;37:279-281. https://doi.org/10.1111/j.1479-828X.1997.tb02408.x
  11. Harder T, Franke K, Kohlhoff R, Plagemann A. Maternal and paternal family history of diabetes in women with gestational diabetes or insulin-dependent diabetes mellitus type I. Gynecol Obstet Invest 2001;51:160-164. https://doi.org/10.1159/000052916
  12. Kelly LA, Lane CJ, Weigensberg MJ, et al. Parental history and risk of type 2 diabetes in overweight Latino adolescents: a longitudinal analysis. Diabetes Care 2007;30:2700-2705. https://doi.org/10.2337/dc07-0050
  13. Kim DJ, Cho NH, Noh JH, Lee MS, Lee MK, Kim KW. Lack of excess maternal transmission of type 2 diabetes in a Korean population. Diabetes Res Clin Pract 2004;65:117-124. https://doi.org/10.1016/j.diabres.2003.11.020

Cited by

  1. Growth patterns of large, small, and appropriate for gestational age infants: impacts of long-term breastfeeding: a retrospective cohort study vol.24, pp.7, 2010, https://doi.org/10.1515/jpem.2011.168
  2. Risk Factors for Gestational Diabetes Mellitus in Korean Women vol.22, pp.2, 2010, https://doi.org/10.7570/kjo.2013.22.2.85
  3. Gestational Diabetes Mellitus in Korean Women: Similarities and Differences from Other Racial/Ethnic Groups vol.38, pp.1, 2010, https://doi.org/10.4093/dmj.2014.38.1.1
  4. Gestational diabetes risk factors and long-term consequences for both mother and offspring: a literature review vol.14, pp.1, 2010, https://doi.org/10.1080/17446651.2018.1476135
  5. The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population vol.10, pp.1, 2010, https://doi.org/10.1038/s41598-020-75797-w
  6. CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Gene Polymorphisms and Gestational Diabetes Mellitus Risk: A Trial Sequential Meta-Analysis of 13,306 Subjects vol.12, pp.None, 2010, https://doi.org/10.3389/fendo.2021.722674
  7. Gestational Diabetes Mellitus (GDM) Risk for Declared Family History of Diabetes, in Combination with BMI Categories vol.18, pp.13, 2010, https://doi.org/10.3390/ijerph18136936