The Korean Journal of Medicine

  • 제79권6호
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  • Pages.710-713
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  • 2010
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지

Paroxetine 복용 후 발생한 항이뇨호르몬 분비이상 증후군 1예

A case of syndrome of inappropriate secretion of antidiuretic hormone associated with paroxetine

  • 안효준 (가톨릭대학교 의학전문대학원 내과학교실) ;
  • 김형욱 (가톨릭대학교 의학전문대학원 내과학교실) ;
  • 김영수 (가톨릭대학교 의학전문대학원 내과학교실) ;
  • 김영옥 (가톨릭대학교 의학전문대학원 내과학교실) ;
  • 윤선애 (가톨릭대학교 의학전문대학원 내과학교실) ;
  • 최재기 (가톨릭대학교 의학전문대학원 내과학교실)
  • Ahn, Hyo-Jun (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Kim, Hyung-Wook (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Kim, Young-Soo (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Kim, Young-Ok (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Yoon, Sun-Ae (Department of Internal Medicine, The Catholic University of Korea School of Medicine) ;
  • Choi, Jae-Ki (Department of Internal Medicine, The Catholic University of Korea School of Medicine)
  • 투고 : 2009.12.09
  • 심사 : 2010.01.05
  • 발행 : 2010.12.01
⟨ 이전 논문 다음 논문 ⟩

초록

저자들은 우울증으로 paroxetine을 투여받은 후 전신 쇠약감과 저나트륨혈증이 발생한 환자에서 SIADH를 진단한 증례를 경험하여 국내 최초로 보고하는 바이다.

Paroxetine is a well-known selective serotonin reuptake inhibitor, and has been reported to be advantageous for chronic pain control. Paroxetine is increasingly used for various types of chronic pain because of its safety; however, hyponatremia, or syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with paroxetine, has been reported. This complication is relatively rare, but some patients have presented with severe neurological symptoms. Here, we report the first case of SIADH associated with paroxetine in Korea.

키워드

참고문헌

  1. Masand PS, Narasimhan M, Patkar A. Paroxetine for somatic pain associated with physical illness: a review. Prim Care Companion J Clin Psychiatry 8:122-130, 2006 https://doi.org/10.4088/PCC.v08n0301
  2. Kubota T, Miyata A. Syndrome of inappropriate secretion of antidiuretic hormone associated with paroxetine. J Anesth 20:126-128, 2006 https://doi.org/10.1007/s00540-005-0381-6
  3. Malik AR, Wolf PK, Ravasia S. Recurrent paroxetine-induced hyponatremia. Can J Psychiatry 49:785, 2004
  4. Wakita M, Matsuoka H, Hamada R, Okatsu H, Nakajima T, Osame M. Hyponatremia upon resumption of paroxetine therapy. Intern Med 44:240-242, 2005 https://doi.org/10.2169/internalmedicine.44.240
  5. Odeh M, Seligmann H, Oliven A. Severe life-threatening hyponatremia during paroxetine therapy. J Clin Pharmacol 39:1290-1291, 1999 https://doi.org/10.1177/00912709922011980
  6. Rosner MH. Severe hyponatremia associated with the combined use of thiazide diuretics and selective serotonin reuptake inhibitors. Am J Med Sci 327:109-111, 2004 https://doi.org/10.1097/00000441-200402000-00012
  7. Bartter FC. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Dis Mon:1-47, 1973
  8. Anderson IM. Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability. J Affect Disord 58:19-36, 2000 https://doi.org/10.1016/S0165-0327(99)00092-0
  9. Baldwin DS, Anderson IM, Nutt DJ, Bandelow B, Bond A, Davidson JR, den Boer JA, Fineberg NA, Knapp M, Scott J, Wittchen HU. Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology. J Psychopharmacol 19:567-596, 2005 https://doi.org/10.1177/0269881105059253
  10. Jung AC, Staiger T, Sullivan M. The efficacy of selective serotonin reuptake inhibitors for the management of chronic pain. J Gen Intern Med 12:384-389, 1997 https://doi.org/10.1007/s11606-006-5088-3
  11. Montgomery SA. A meta-analysis of the efficacy and tolerability of paroxetine versus tricyclic antidepressants in the treatment of major depression. Int Clin Psychopharmacol 16:169-178, 2001 https://doi.org/10.1097/00004850-200105000-00006
  12. Rapaport MH, Schneider LS, Dunner DL, Davies JT, Pitts CD. Efficacy of controlled-release paroxetine in the treatment of late-life depression. J Clin Psychiatry 64:1065-1074, 2003 https://doi.org/10.4088/JCP.v64n0912
  13. Yonkers KA, Lin H, Howell HB, Heath AC, Cohen LS. Pharmacologic treatment of postpartum women with new-onset major depressive disorder: a randomized controlled trial with paroxetine. J Clin Psychiatry 69:659-665, 2008 https://doi.org/10.4088/JCP.v69n0420
  14. Wilkinson TJ, Begg EJ, Winter AC, Sainsbury R. Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people. Br J Clin Pharmacol 47:211-217, 1999
  15. Kazal LA Jr, Hall DL, Miller LG, Noel ML. Fluoxetine-induced SIADH: a geriatric occurrence? J Fam Pract 36:341-343, 1993
  16. Lindeman RD, Van Buren HC, Raisz LG. Osmolar renal concentrating ability in healthy young men and hospitalized patients without renal disease. N Engl J Med 262:1306-1309, 1960 https://doi.org/10.1056/NEJM196006302622603
  17. Miller M. Fluid and electrolyte balance in the elderly. Geriatrics 42:65-68, 71, 75-76, 1987
  18. Helderman JH, Vestal RE, Rowe JW, Tobin JD, Andres R, Robertson GL. The response of arginine vasopressin to intravenous ethanol and hypertonic saline in man: the impact of aging. J Gerontol 33:39-47, 1978 https://doi.org/10.1093/geronj/33.1.39
  19. Fabian TJ, Amico JA, Kroboth PD, Mulsant BH, Corey SE, Begley AE, Bensasi SG, Weber E, Dew MA, Reynolds CF 3rd, Pollock BG. Paroxetine-induced hyponatremia in older adults: a 12-week prospective study. Arch Intern Med 164:327-332, 2004 https://doi.org/10.1001/archinte.164.3.327
  20. Schwartz WB, Bennett W, Curelop S, Bartter FC. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone: 1957. J Am Soc Nephrol 12:2860-2870, 2001