원발성 간세포암 환자에서 부갑상선 간세포암 전이가 병발한 1예

A case of hepatocellular carcinoma combined with solitary parathyroid metastasis

  • 서미혜 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 김병익 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 이재은 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 송창석 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 윤민용 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 박완 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 김동훈 (성균관대학교 의과대학 강북삼성병원 해부병리과)
  • Seo, Mi-Hye (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School Medicine) ;
  • Kim, Byung-Ik (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School Medicine) ;
  • Lee, Jae-Eun (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School Medicine) ;
  • Song, Chang-Seok (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School Medicine) ;
  • Yoon, Min-Yong (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School Medicine) ;
  • Park, Wan (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School Medicine) ;
  • Kim, Dong-Hoon (Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School Medicine)
  • 투고 : 2009.08.06
  • 심사 : 2010.01.04
  • 발행 : 2010.12.01

초록

저자들은 현재까지 국내외에 원발성 간세포 암의 전이부위로 부갑상선이 보고된 적이 없고 현미경적으로 tumor-to-tumor 전이(공여 부위: 간세포암, 수여 부위: 부갑상선 선종)가 병발한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Extrahepatic metastasis of HCC is now increasing due to prolonged survival. Most extrahepatic HCC occurs in patients with advanced stages. The lung, abdominal lymph nodes, and bone are common sites of extrahepatic metastasis. However, the parathyroid gland has not been reported as a metastatic focus. We report the first case of parathyroid metastasis as the first single metastasis site of HCC and microscopic tumor-to-tumor metastasis to a parathyroid adenoma.

키워드

과제정보

연구 과제 주관 기관 : Sungkyunkwan Univercity

참고문헌

  1. Parikh S, Hyman D. Hepatocellular cancer: a guide for the internist. Am J Med 120:194-202, 2007 https://doi.org/10.1016/j.amjmed.2006.11.020
  2. Livraghi T, Festi D, Monti F, Salmi A, Vettori C. US-guided percutaneous alcohol injection of small hepatic and abdominal tumors. Radiology 161:309-312, 1986 https://doi.org/10.1148/radiology.161.2.3020612
  3. Shuto T, Kinoshita H, Hirohashi K, Kubo S, Tanaka H, Tsukamoto T, Okuda T. Indications for, and effectiveness of, a second hepatic resection for recurrent hepatocellular carcinoma. Hepatogastroenterology 43:932-937, 1996
  4. Yamada R, Sato M, Kawabata M, Nakatsuka H, Nakamura K, Takashima S. Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 148:397-401, 1983
  5. Inagaki Y, Unoura M, Urabe T, Ogino H, Terasaki S, Matsushita E, Kaneko S, Morioka T, Furusawa A, Wakabayashi T. Distant metastasis of hepatocellular carcinoma after successful treatment of the primary lesion. Hepatogastroenterology 40:316-319, 1993
  6. Natsuizaka M, Omura T, Akike T, Kuwata Y, Yamazaki K, Sato T, Karino Y, Toyota J, Suga T, Asaka M. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol 20:1781-1787, 2005 https://doi.org/10.1111/j.1440-1746.2005.03919.x
  7. Nakashima T, Okuda K, Kojiro M, Jimi A, Yamaguchi R, Sakamoto K, Ikari T. Pathology of hepatocellular carcinoma in japan: 232 consecutive cases autopsied in ten years. Cancer 51:868-877, 1983
  8. Katyal S, Oliver JH 3rd, Peterson MS, Ferris JV, Carr BS, Baron RL. Extrahepatic metastases of hepatocellular carcinoma. Radiology 216:698-703, 2000 https://doi.org/10.1148/radiology.216.3.r00se24698
  9. 문준호, 박상훈. 간세포암종에서 간외전이의 진단 및 치료. 대한 간암연구회지 6:12-19, 2006
  10. Fukutomi M, Yokota M, Chuman H, Harada H, Zaitsu Y, Funakoshi A, Wakasugi H, Iguchi H. Increased incidence of bone metastases in hepatocellular carcinoma. Eur J Gastroenterol Hepatol 13:1083-1088, 2001 https://doi.org/10.1097/00042737-200109000-00015
  11. Berent W. Seltene metastsenbildung. Zentralbl Allg Pathol Pathol Anat 13:406-410, 1902
  12. Dobbing J. Cancer to cancer. Guys Hosp Rep 107:60-65, 1958
  13. Campbell LV Jr, Gilbert E, Chamberlain CR Jr, Watne AL. Metastases of cancer to cancer. Cancer 22:635-643, 1968 https://doi.org/10.1002/1097-0142(196809)22:3<635::AID-CNCR2820220320>3.0.CO;2-O
  14. Ro JY, Sahin AA, Ayala AG, Ordonez NG, Grignon DJ, Popok SM. Lung carcinoma with metastasis to testicular seminoma. Cancer 66:347-353, 1990 https://doi.org/10.1002/1097-0142(19900715)66:2<347::AID-CNCR2820660224>3.0.CO;2-I
  15. Sella A, Ro JY. Renal cell cancer: best recipient of tumor-to-tumor metastasis. Urology 30:35-38, 1987 https://doi.org/10.1016/0090-4295(87)90568-1
  16. Ricketts R, Tamboli P, Czerniak B, Guo CC. Tumor-to-tumor metastasis: report of 2 cases of metastatic carcinoma to angiomyolipoma of the kidney. Arch Pathol Lab Med 132:1016-1020, 2008