당뇨병 환자에서의 결핵

Tuberculosis in diabetic patient

  • 최재철 (중앙대학교 의과대학 내과학교실, 호흡기알레르기내과)
  • Choi, Jae-Chol (Division of Pulmonary Disease, Department of Internal Medicine, Chung-Ang University School of Medicine)
  • 발행 : 2010.12.01

초록

Tuberculosis (TB) and diabetes mellitus (DM) are major global health problem. The link between DM and TB has been recognized for centuries. And, there are growing evidences that diabetes is a risk factor for tuberculosis. However, the risk varies according to races and regional prevalence, but limited data is available in South Korea. The report of Park et al. showed that the relative odds ratio was 2.220 (95% CI 1.090~4.523) in diabetic group, compared with hypertensive group. Although this study has some limitations, it is a meaningful data. A large-scale multi-center prospective study is needed in Korean population.

키워드

참고문헌

  1. Zykova SN, Jenssen TG, Berdal M, Olsen R, Myklebust R, Seljelid R. Altered cytokine and nitric oxide secretion in vitro by macrophages from diabetic type II-like db/db mice. Diabetes 49:1451-1458, 2000 https://doi.org/10.2337/diabetes.49.9.1451
  2. Dooley KE, Chaisson RE. Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect Dis 9:737-746, 2009 https://doi.org/10.1016/S1473-3099(09)70282-8
  3. Yamashiro S, Kawakami K, Uezu K, Kinjo T, Miyagi K, Nakamura K, Saito A. Lower expression of Th1-related cytokines and inducible nitric oxide synthase in mice with streptozotocin-induced diabetes mellitus infected with mycobacterium tuberculosis. Clin Exp Immunol 139:57-64, 2005 https://doi.org/10.1111/j.1365-2249.2005.02677.x
  4. Sugawara I, Yamada H, Mizuno S. Pulmonary tuberculosis in spontaneously diabetic goto kakizaki rats. Tohoku J Exp Med 204:135-145, 2004 https://doi.org/10.1620/tjem.204.135
  5. Oluboyo PO, Erasmus RT. The significance of glucose intolerance in pulmonary tuberculosis. Tubercle 71:135-138, 1990 https://doi.org/10.1016/0041-3879(90)90010-6
  6. Jawad F, Shera AS, Memon R, Ansari G. Glucose intolerance in pulmonary tuberculosis. J Park Med Assoc 45:237-238, 1995
  7. Jeon CY, Murray MB. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med 5:e152, 2008 https://doi.org/10.1371/journal.pmed.0050152
  8. Niemi M, Backman JT, Neuvonen M, Neuvonen PJ, Kivisto KT. Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide. Clin Pharmacol Ther 69:400-406, 2001 https://doi.org/10.1067/mcp.2001.115822
  9. Tatar D, Senol G, Alptekin S, Karakurum C, Aydin M, Coskunol I. Tuberculosis in diabetics: features in an endemic area. Jpn J Infect Dis 62:423-427, 2009
  10. Bacakoglu F, Basoglu OK, Cok G, Sayiner A, Ates M. Pulmonary tuberculosis in patients with diabetes mellitus. Respiration 68:595-600, 2001 https://doi.org/10.1159/000050578
  11. Wang CS, Yang CJ, Chen HC, Chuang SH, Chong IW, Hwang JJ, Huang MS. Impact of type 2 diabetes on manifestations and treatment outcome of pulmonary tuberculosis. Epidemiol Infect 137:203-210, 2009 https://doi.org/10.1017/S0950268808000782
  12. Alisjahbana B, Sahiratmadja E, Nelwan EJ, Purwa AM, Ahmad Y, Ottenhoff TH, Nelwan RH, Parwati I, van der Meer JW, van Crevel R. The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis. Clin Infect Dis 45:428-435, 2007 https://doi.org/10.1086/519841