The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지

Angiogenesis and cell therapy

혈관신생과 세포치료

  • Kim, Jeong-A (Division of Hematology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
  • 김정아 (가톨릭대학교 의과대학 내과학교실, 혈액내과)
  • Published : 2010.12.01
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Abstract

All cells in human body receive oxygen and nutrients and remove metabolic wastes through the vascular network. New vessel formation in a human body is significantly decreased in adults compared with fetus. New vessel formation is a critical process in pathogenesis, thus, it is a therapeutic target in several diseases, such as cancer, diabetic retinopathy, myocardial infarction and cerebral ischemia. Angiogenesis initiates through the interaction of several factors. For the increment of angiogenesis, new vessel promoting factors, such as vascular endothelial growth factor, or their genes have been directly injected to patients in the past. However, in recent studies, direct injection of cells promoting blood flow to patients has been attempted. In this paper, I will focus on cell therapy and its application in promoting blood flow in patients with impaired vessel such as myocardial infarction, cerebral ischemia and limb ischemia.

Keywords

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