The Korean Journal of Medicine

  • 제79권5호
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  • Pages.506-508
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  • 2010
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지

Sunitinib에 의한 갑상선기능저하증

Sunitinib-induced hypothyroidism

  • 정윤재 (중앙대학교 의과대학 중앙대학교병원 내분비내과)
  • Chung, Yun-Jae (Division of Endocrinology, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine)
  • 발행 : 2010.11.01
⟨ 이전 논문 다음 논문 ⟩

초록

Sunitinib is an oral multi-targeted tyrosine kinase inhibitor that is effective for advanced renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor. Currently, sunitinib is being investigated in multiple other tumor types including non-small cell lung cancer, breast cancer, colon cancer, and endocrine tumors. Recent studies have shown that sunitinib induces thyroid dysfunction, mainly hypothyroidism during treatment. The incidence of sunitinib-induced hypothyroidism has been reported to be 36~85%. Although several hypotheses have been suggested, the mechanisms by which sunitinib induces hypothyroidism are not clear. As considered the fairly high incidence of sunitinib-induced hypothyroidism, thyroid function should be regularly monitored in all patients treated with sunitinib.

키워드

참고문헌

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