Anatomy and Cell Biology

Korean Association of Anatomists (대한해부학회)
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Assessment of experimental saccular aneurysm using selective angiography in common carotid artery of rabbits

  • Chang, Dong-Woo (Department of Veterinary Radiology, College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Bong-Kyung (Medical Research Center, Yonsei University College of Medicine) ;
  • Shin, Jae-Hoon (Department of Veterinary Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University) ;
  • Yoon, Young-Min (Medical Research Center, Yonsei University College of Medicine) ;
  • Oh, Seung-Hyun (Medical Research Center, Yonsei University College of Medicine) ;
  • Yoon, Yeo-Sung (Department of Veterinary Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University) ;
  • Hong, Sung-Hyeok (Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health) ;
  • Lee, Ki-Chang (Department of Veterinary Radiology, College of Veterinary Medicine, Chonbuk National University) ;
  • Lee, Young-Won (Department of Veterinary Radiology, College of Veterinary Medicine, Chungnam National University) ;
  • Seo, Kang-Moon (Department of Veterinary Surgery) ;
  • Kweon, Oh-Kyeong (Department of Veterinary Surgery) ;
  • Yoon, Jung-Hee (Veterinary Radiology) ;
  • Shin, Nam-Shik (Zoo and Wild Animal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Kyu-Ho (Medical Research Center, Yonsei University College of Medicine) ;
  • Suh, Jun-Gyo (Department of Medical Genetics, College of Medicine, Hallym University) ;
  • Seong, Je-Kyung (Medical Research Center, Yonsei University College of Medicine)
  • Received : 2010.02.09
  • Accepted : 2010.04.02
  • Published : 2010.06.30
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Abstract

In order to study the treatment of aneurysms, the technique of making experimental aneurysms in laboratory animals must be established. In our study, to examine the feasibility of making experimental aneurysm and selective angiography on the common carotid artery in rabbits and to determine the size of experimental aneurysm after surgery, saccular aneurysms were fashioned on the right common carotid artery in 17 rabbits using a vein pouch technique. Selective angiography of the common carotid artery was performed immediately aft er surgery, and at 1 week, 4 weeks, and 8 weeks after surgery. Also, histological changes in the aneurysms were observed. In 16 rabbits with established successful experimental aneurysm, no differences were found in diet intake and behavior before and after surgery. The patency of the carotid artery was confirmed by selective angiography. The average size of the aneurysm immediately after surgery was similar to that of 1 week postoperatively in selective angiography, however it increased with time at 4weeks and 8 weeks. Histologically, infiltration of inflammatory cells and hemorrhage were found at the junction of the carotid artery and the vein pouch at 1 week, which disappeared at 4 weeks and 8 weeks. This study suggests experimental saccular aneurysm using the vein pouch technique might form aneurysms similar to that of the human in its properties such as increment of size, and selective angiography might be suitable for assessment of experimental aneurysm. Therefore, this animal model may be suitable for investigating new treatment methodologies for human aneurysms.

Keywords

Acknowledgement

Grant : Priority Research Cencers Program

Supported by : National Research Foundation of Korea (NRF), Ministry of Health

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