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Assessment of experimental saccular aneurysm using selective angiography in common carotid artery of rabbits

  • Chang, Dong-Woo (Department of Veterinary Radiology, College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Bong-Kyung (Medical Research Center, Yonsei University College of Medicine) ;
  • Shin, Jae-Hoon (Department of Veterinary Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University) ;
  • Yoon, Young-Min (Medical Research Center, Yonsei University College of Medicine) ;
  • Oh, Seung-Hyun (Medical Research Center, Yonsei University College of Medicine) ;
  • Yoon, Yeo-Sung (Department of Veterinary Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University) ;
  • Hong, Sung-Hyeok (Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health) ;
  • Lee, Ki-Chang (Department of Veterinary Radiology, College of Veterinary Medicine, Chonbuk National University) ;
  • Lee, Young-Won (Department of Veterinary Radiology, College of Veterinary Medicine, Chungnam National University) ;
  • Seo, Kang-Moon (Department of Veterinary Surgery) ;
  • Kweon, Oh-Kyeong (Department of Veterinary Surgery) ;
  • Yoon, Jung-Hee (Veterinary Radiology) ;
  • Shin, Nam-Shik (Zoo and Wild Animal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Kyu-Ho (Medical Research Center, Yonsei University College of Medicine) ;
  • Suh, Jun-Gyo (Department of Medical Genetics, College of Medicine, Hallym University) ;
  • Seong, Je-Kyung (Medical Research Center, Yonsei University College of Medicine)
  • Received : 2010.02.09
  • Accepted : 2010.04.02
  • Published : 2010.06.30

Abstract

In order to study the treatment of aneurysms, the technique of making experimental aneurysms in laboratory animals must be established. In our study, to examine the feasibility of making experimental aneurysm and selective angiography on the common carotid artery in rabbits and to determine the size of experimental aneurysm after surgery, saccular aneurysms were fashioned on the right common carotid artery in 17 rabbits using a vein pouch technique. Selective angiography of the common carotid artery was performed immediately aft er surgery, and at 1 week, 4 weeks, and 8 weeks after surgery. Also, histological changes in the aneurysms were observed. In 16 rabbits with established successful experimental aneurysm, no differences were found in diet intake and behavior before and after surgery. The patency of the carotid artery was confirmed by selective angiography. The average size of the aneurysm immediately after surgery was similar to that of 1 week postoperatively in selective angiography, however it increased with time at 4weeks and 8 weeks. Histologically, infiltration of inflammatory cells and hemorrhage were found at the junction of the carotid artery and the vein pouch at 1 week, which disappeared at 4 weeks and 8 weeks. This study suggests experimental saccular aneurysm using the vein pouch technique might form aneurysms similar to that of the human in its properties such as increment of size, and selective angiography might be suitable for assessment of experimental aneurysm. Therefore, this animal model may be suitable for investigating new treatment methodologies for human aneurysms.

Keywords

Acknowledgement

Grant : Priority Research Cencers Program

Supported by : National Research Foundation of Korea (NRF), Ministry of Health

References

  1. Allcock J, Canham P. (1976). Angiographic study of the growth of intracranial aneurysms. J Neurosurg 45: 617-621 https://doi.org/10.3171/jns.1976.45.6.0617
  2. Bookstein JJ, Chlosta EM, Foley D, Walter JF. (1974). Transcatheter hemostasis of gastrointestinal bleeding using modified autogenous clot. Radiology 113: 277-285 https://doi.org/10.1148/113.2.277
  3. Byrne JV, Sohn MJ, Molyneux AJ, Chir B. (1999). Five-year experience in using coil embolization for ruptured intracranial aneurysms: outcomes and incidence of late rebleeding. J Neurosurg 90: 656-663 https://doi.org/10.3171/jns.1999.90.4.0656
  4. Drake CG, Friedman AH, Peerless SJ. (1984). Failed aneurysm surgery: reoperation in 115 cases. J Neurosurg 61: 848-856 https://doi.org/10.3171/jns.1984.61.5.0848
  5. Forrest MD, O'Reilly GV. (1989). Production of experimental aneurysms at a surgically created arterial bifurcation. AJNR Am J Neuroradiol 10: 400-402
  6. German WJ, Black SP. (1954). Experimental production of carotid aneurysms. N Engl J Med 250: 104-106 https://doi.org/10.1056/NEJM195401212500303
  7. Gertz SD, Kurgan A, Eisenberg D. (1988). Aneurysm of the rabbit common carotid artery induced by periarterial application of calcium chloride in vivo. J Clin Invest 81: 649-656 https://doi.org/10.1172/JCI113368
  8. Guglielmi G, Ji C, Massoud TF, Kurata A, Lownie SP, Vinuela F, Robert J. (1994). Experimental saccular aneurysms. Neuroradiology 36: 547-550 https://doi.org/10.1007/BF00593518
  9. Hashimoto N, Kim C, Kikuchi H, Kojima M, Kang Y, Hazama F. (1987). Experimental induction of cerebral aneurysms in monkeys. J Neurosurg 67: 903-905 https://doi.org/10.3171/jns.1987.67.6.0903
  10. Heilman CB, Kwan ES, Wu JK. (1992). Aneurysm recurrence following endovascular balloon occlusion. J Neurosurg 77: 260-264 https://doi.org/10.3171/jns.1992.77.2.0260
  11. Kirse DJ, Flock S, Teo C, Rahman S, Mrak R. (1996). Construction of a vein-pouch aneurysm at a surgically created carotid bifurcation in the rat. Microsurgery 17: 681-689 https://doi.org/10.1002/(SICI)1098-2752(1996)17:12<681::AID-MICR5>3.0.CO;2-Q
  12. Krings T, Hans FJ, Moller-Hartmann W, et al. (2002). Time-of-flight-, phase contrast and contrast enhanced magnetic resonance angiography for pre-interventional determination of aneurysm size, confi guration, and neck morphology in an aneurysm model in rabbits. Neurosci Lett 326: 46-50 https://doi.org/10.1016/S0304-3940(02)00308-7
  13. Massoud TF, JI C, Guglielmi G, Vinuela F, Robert J. (1994). Experimental models of bifurcation and terminal aneurysms: construction techniques in swine. AJNR Am J Neuroradiol 15: 938-944
  14. Osterman FA, Bell WR, Montali RJ, Novak GR, White RI. (1976). Natural history of autologous blood clot embolization in swine. Invest Radiol 11: 267-276 https://doi.org/10.1097/00004424-197607000-00003
  15. Quigley MR, Tuite GF, Cozzens JW. (1988). Histology and angiography in a bifurcation aneurysm model. Surg Neurol 30: 445-451 https://doi.org/10.1016/0090-3019(88)90029-8
  16. Stehbens WE. (1981a). Chronic changes in experimental saccular and fusiform aneurysms in rabbits. Arch Pathol Lab Med 105: 603-607
  17. Stehbens WE. (1981b). Chronic vascular changes in the walls of experimental berry aneurysms of the aortic bifurcation in rabbits. Stroke 12: 643-647 https://doi.org/10.1161/01.STR.12.5.643
  18. Szikora I, Wakhloo AK, Guterman LR, et al. (1997). Initial experience with collagen-fi lled Guglielmi detachable coils for endovascular treatment of experimental aneurysms. AJNR Am J Neuroradiol 18: 667-672
  19. White JC, Sayre GP, Whisnant JP. (1961). Experimental destruction of the media for the production of intracranial arterial aneurysms. J Neurosurg 18: 741-745 https://doi.org/10.3171/jns.1961.18.6.0741