Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Comparison of D-[18F]FMAU and L-[18F]FMAU as PET Imaging Agents for HSV1-TK Gene Expression

  • Moon, Byung-Seok (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences) ;
  • Jo, Nam-Hyun (Biomaterials Center, Korea Institute of Science and Technology) ;
  • Lee, Kyo-Chul (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences) ;
  • El-Gamal, Mohammed I. (Biomaterials Center, Korea Institute of Science and Technology) ;
  • An, Gwang-Il (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences) ;
  • Hong, Su-Hee (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences) ;
  • Choi, Tae-Hyun (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences) ;
  • Choi, Won-Kyoung (Biomaterials Center, Korea Institute of Science and Technology) ;
  • Park, Jin-Hun (Biomaterials Center, Korea Institute of Science and Technology) ;
  • Cho, Jung-Hyuck (Biomaterials Center, Korea Institute of Science and Technology) ;
  • Cheon, Gi-Jeong (Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences) ;
  • Oh, Chang-Hyun (Biomaterials Center, Korea Institute of Science and Technology)
  • Received : 2010.05.10
  • Accepted : 2010.09.15
  • Published : 2010.11.20
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Abstract

D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines. D-[$^{18}F$]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[$^{18}F$]FMAU. On the other hand, L-[$^{18}F$]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[$^{18}F$]FMAU. L-[$^{18}F$]FMAU can be utilized as a good candidate for HSV1-TK PET imaging. It can be used for antiviral drug evaluation.

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References

  1. Kwon, H. C.; Kim, J. H.; Kim, K. C.; Lee, K. H.; Lee, J. H.; Lee, B. H.; Lee, K. H.; Jang, J. J.; Lee, C. T.; Lee, H.; Kim, C. M. Mol. Cells 2001, 11, 170.
  2. Mullen, C. A. Pharm. Ther. 1994, 63, 199. https://doi.org/10.1016/0163-7258(94)90046-9
  3. Haberkorn, U.; Khazaie, K.; Morr, I.; Altmann, A.; Müller, M.; Kaick, G. V. Nucl. Med. Biol. 1998, 25, 367. https://doi.org/10.1016/S0969-8051(97)00210-2
  4. Choi, T. H.; Soon, H. A.; Kwon, H. C.; Choi, C. W.; Awh, O. D.; Lim, S. M. Appl. Radiat. Isot. 2004, 60, 15. https://doi.org/10.1016/j.apradiso.2003.08.006
  5. Adamsen, T. C. H.; Krohn, K. A.; Abstracts of Papers; 231st American Chemical Society National Meeting, ACS: Washington, DC, 2006.
  6. Ahn, H.; Choi, T. H.; De Castro, K.; Lee, K. C.; Kim, B.; Moon, B. S.; Hong, S. H.; Lee, J. C.; Chun, K. S.; Cheon, G. J.; Lim, S. M.; An, G. I.; Rhee, H. J. Med. Chem. 2007, 50, 6032. https://doi.org/10.1021/jm070791g
  7. Colacino, J. M. Antiviral Res. 1996, 29, 125. https://doi.org/10.1016/0166-3542(95)00836-5
  8. Horn, D. M.; Neeb, L. A.; Colacino, J. M.; Richardson, F. C. Antiviral Res. 1997, 34, 71. https://doi.org/10.1016/S0166-3542(96)01027-3
  9. Alauddin, M. M.; Conti, P. S.; Fissekis, J. D. J. Labelled Compd. Radiopharm. 2002, 45, 583. https://doi.org/10.1002/jlcr.549
  10. Alauddin, M. M.; Ghosh, P.; Gelovani, J. G. J. Labelled Compd. Radiopharm. 2006, 49, 1079. https://doi.org/10.1002/jlcr.1127
  11. Samuelsson, L.; Långström, B. J. Labelled Compd. Radiopharm. 2003, 46, 263. https://doi.org/10.1002/jlcr.668
  12. Conti, P. S.; Alauddin, M. M.; Fissekis, J. D.; Watanabe, K. A. Nucl. Med. Biol. 1995, 22, 783. https://doi.org/10.1016/0969-8051(95)00017-R
  13. Sun, H.; Sloan. A.; Mangner, T. J.; Vaishampayan, U.; Muzik, O.; Collins, J. M.; Douglas, K.; Shields, A. F. Eur. J. Nucl. Med. Mol. Imaging 2005, 32, 15. https://doi.org/10.1007/s00259-004-1713-8
  14. Kim, E. J.; Hong, S. H.; Choi, T. H.; Lee, E. A.; Kim, K. M.; Lee, K. C.; An, G. I.; El-Gamal, M. I.; Cheon, G. J.; Choi, C. W.; Lim, S. M. Appl. Radiat. Isot. 2010, 68, 971. https://doi.org/10.1016/j.apradiso.2009.12.032
  15. Gumina, G.; Chong, Y.; Choo, H.; Song, G. Y.; Chu, C. K. Curr. Top. Med. Chem. 2002, 2, 1065. https://doi.org/10.2174/1568026023393138
  16. Choi, S. R.; Zhuang, Z. P.; Chacko, A. M.; Acton, P. D.; Tjuvajev-Gelovani, J.; Doubrovin, M.; Chu, D. C. K.; Kung, H. F. Acad. Radiol. 2005, 12, 798. https://doi.org/10.1016/j.acra.2005.04.010
  17. Jo, N. H.; Moon, B. S.; Hong, S. H.; An, G. I.; Choi, T. H.; Cheon, G. J.; Cho, J.-H.; Yoo, K. H.; Lee, K. C.; Oh, C.-H. Bull. Korean Chem. Soc. 2007, 28, 2449. https://doi.org/10.5012/bkcs.2007.28.12.2449

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