Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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EFFECTS OF HYPOXIA ON THE FORMATION OF OSTEOCLAST

저산소증이 파골세포 분화에 미치는 영향에 관한 연구

  • Sim, Hye-Young (Department of orthodontics, Seoul Municipal Boramae Hospital) ;
  • Jung, Da-Un (Department of Prosthodontics, Seoul Municipal Boramae Hospital) ;
  • Chae, Chang-Hoon (NanoCureTech Inc) ;
  • Lee, Young (Hallym University) ;
  • Jang, Eun-Sik (Hallym University) ;
  • Choi, Mee-Ra (Department of Prosthodontics, KangDong Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Hong, Soon-Min (Department of Oral & Maxillogfacial Surgery, KangDong Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Park, Jun-Woo (Department of Oral & Maxillogfacial Surgery, KangDong Sacred Heart Hospital, College of Medicine, Hallym University)
  • 심혜영 (서울시립보라매병원 교정과) ;
  • 정다운 (서울시립보라매병원 보철과) ;
  • 채창훈 (나노큐어텍) ;
  • 이영 (한림대학교 의학과 대학원) ;
  • 장은식 (한림대학교 의학과 대학원) ;
  • 최미라 (한림대학교 의과대학 강동성심병원 보철과) ;
  • 홍순민 (한림대학교 의과대학 강동성심병원 구강악안면외과) ;
  • 박준우 (한림대학교 의과대학 강동성심병원 구강악안면외과)
  • Received : 2009.11.30
  • Accepted : 2010.01.12
  • Published : 2010.01.29
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Abstract

The vascular changes in periodontal tissues cause local hypoxia which seems to affect the periodontal tissue cells. Abrupt changes in oxygen availability within the periodontium have been suggested to have a regulatory role in alveolar bone remodeling during tooth movement, bone growth or fracture healing. The purpose of this study was to study the effects of hypoxia on formation of osteoclast responsible for bone resorption, in vitro. Primary mouse bone marrow cells were cultured in normoxic (20% $O_2$) and hypoxic (1% $O_2$) conditions and assayed for cellular proliferation. The results obtained were as follows : 1. Reducing oxygen tension increased the formation of multinucleated osteoclasts. 2. Hypoxic stimulus increased the size of mature osteoclasts.

Keywords

References

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