Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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Toxicity of PFCs in Embryos of the Oryzias latipes Using Flow though Exposure System

유수식 연속노출장비를 이용한 과불화화합물(PFOS, PFOA)이 송사리 (Oryzias latipes) 알의 초기발생과정에 미치는 영향 연구

  • Cho, Jae-Gu (Risk Assessment Divison, National Institute of Environmental Research) ;
  • Kim, Kyung-Tae (Risk Assessment Divison, National Institute of Environmental Research) ;
  • Ryu, Tae-Kwon (Risk Assessment Divison, National Institute of Environmental Research) ;
  • Park, Yu-Ri (Risk Assessment Divison, National Institute of Environmental Research) ;
  • Yoon, Jun-Heon (Risk Assessment Divison, National Institute of Environmental Research) ;
  • Lee, Chul-Woo (Risk Assessment Divison, National Institute of Environmental Research) ;
  • Kim, Hyun-Mi (Future Strategy Research team, National Institute of Environmental Research) ;
  • Choi, Kyung-Hee (Risk Assessment Divison, National Institute of Environmental Research) ;
  • Jung, Ki-Eun (Risk Assessment Divison, National Institute of Environmental Research)
  • 조재구 (국립환경과학원 환경건강위해성연구부 위해성평가과) ;
  • 김경태 (국립환경과학원 환경건강위해성연구부 위해성평가과) ;
  • 류태권 (국립환경과학원 환경건강위해성연구부 위해성평가과) ;
  • 박유리 (국립환경과학원 환경건강위해성연구부 위해성평가과) ;
  • 윤준헌 (국립환경과학원 환경건강위해성연구부 위해성평가과) ;
  • 이철우 (국립환경과학원 환경건강위해성연구부 위해성평가과) ;
  • 김현미 (국립환경과학원 연구전략기획실 미래전략연구팀) ;
  • 최경희 (국립환경과학원 환경건강위해성연구부 위해성평가과) ;
  • 정기은 (국립환경과학원 환경건강위해성연구부 위해성평가과)
  • Received : 2010.02.24
  • Accepted : 2010.06.01
  • Published : 2010.06.30
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Abstract

Perfluorinated chemicals (PFCs) is a kinds of persistent organic pollutants, and have the potential toxicity of which is causing great concern. In this study, we employed Oryzias latipes embryos to investigate the developmental toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)s compound using flowthrow system for 14 day. O. latipes embryos were exposed to solvent control, 20, 40 and 80 mg/L of PFOS and 62.5, 130, 260 mg/L of PFOA respectively. After exposure, hatchability, mortality, total length and heart beats were examined. Hatching rates were reduced approximately 27% in the 80 mg/L PFOS-treated group and 17% in the 62.5, 130 mg/L PFOA-treated groups. Heart beats in the PFOS-treated groups were reduced at 7 day but, PFOA-treated groups were increased heart beats. 80 mg/L PFOS treated group showed significant reduction in growth (total length) level to 90% of control. But PFOA did not showed significant effect on growth. In the 14 days $LC_{50}$ of PFOS and PFOA was 22.74 mg/L and 173 mg/L, respectively. The overall results indicated that the early stage of O. latipes might be a reliable model for the testing of developmental toxicity to perfluorinated chemicals.

Keywords

References

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