Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Diagnostic Imaging of Massive Hepatocellular Carcinoma in 5 Dogs

개의 종괴형 간세포암종에 대한 진단 영상 소견에 대한 고찰

  • 최지혜 (해마루 이차진료동물병원) ;
  • 김아림 (해마루 이차진료동물병원) ;
  • 계서연 (해마루 이차진료동물병원) ;
  • 최희연 (해마루 이차진료동물병원) ;
  • 장재영 (해마루 이차진료동물병원) ;
  • 윤정희 (서울대학교 수의과대학)
  • Accepted : 2010.08.03
  • Published : 2010.08.30
Download PDF
⟨ Previous Next ⟩

Abstract

Hepatocellular carcinoma (HCC) is a primary hepatic neoplasms in dogs. Three types of HCC such as massive, nodular and diffuse form were reported. Massive HCC is most common and has relatively better prognosis than other forms because this type of HCC can be removed surgically and has low frequency of relapse or metastasis. Diagnostic image can provide useful information for shape and internal structure of the hepatic mass as well as the location and adhesion or invasiveness of the mass to establish surgical plan to remove the mass safely. In this study, we investigated diagnostic features of massive HCC in 5 dogs. Radiography showed soft tissue mass in cranial abdomen in 3 dogs. On ultrasonography, all dogs had a solitary hepatic mass with mixed echo pattern with anechoic cysts, which represented necrosis and hemorrhage. The radiographic and ultrasonographic findings of affected hepatic lobe were compared with the macroscopic findings through laparotomy. Computed tomography was performed to check metastasis and figure out the origin of the mass in two dogs. Ultrasonography is useful and relatively sensitive examination for diagnosis and planning for surgery in canine massive HCC.

Keywords

References

  1. Befeler AS, Bisceglie AM. Hepatocellular carcinoma: diagnosis and treatment. Gastroenterology 2002; 122: 1609-1619. https://doi.org/10.1053/gast.2002.33411
  2. Bruix J, Llovet JM. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 2002; 35: 519-524. https://doi.org/10.1053/jhep.2002.32089
  3. Clifford CA, Pretorius ES, Weisse C, Sorenmo KU, Drobatz KJ, Siegelman ES, Solomon JA. Magnetic resonance imaging of focal splenic and hepatic lesions in the dog. J Vet Intern Med 2004; 18: 330-338. https://doi.org/10.1111/j.1939-1676.2004.tb02554.x
  4. Coakley FV, Schwartz LH. Imaging of hepatocellular carcinoma: a practical approach. Semin Oncol 2001; 28: 460-473. https://doi.org/10.1016/S0093-7754(01)90139-3
  5. Crow SE. Clinical veterinary oncology. Tumors of the alimentary tract. Vet Clin North Am Small Anim Pract 1985; 15: 577-596.
  6. Cuccovillo A, Lamb CR. Cellular features of sonographic target lesions of the liver and spleen in 21 dogs and a cat. Vet Radiol Ultrasound 2002; 43: 275-278. https://doi.org/10.1111/j.1740-8261.2002.tb01003.x
  7. Evans HE. In: Evans HE, Christensen GC, eds. Miller's anatomy of the dog, 2nd ed. Philadelphia: WB Saunders. 1979: 777-778.
  8. Eves NG. Hepatocellular adenoma in a 12-year-old crossbred German shepherd dog. Can Vet J 2004; 45: 326-328.
  9. Feeney DA, Johnston GR, Hardy RM. Two-dimensional, grayscale ultrasonography for assessment of hepatic and splenic neoplasia in the dog and cat. J Am Vet Med Assoc. 1984; 184: 68-81.
  10. Gumerlock PH, Kraegel SA, Madewell BR. Detection of mammalian and avian hepadenovirus by the polymerase chain reaction. J Vet Microbiol 1992; 32: 273-280. https://doi.org/10.1016/0378-1135(92)90150-R
  11. Hammer AS, Sikkema DA. Hepatic neoplasia in the dog and cat. Vet Clin North Am Small Anim Pract 1995; 25: 419-435.
  12. Hunt GB, Bellenger CR, Borg R, Youmans KR, Tisdall PL, Malik R. Congenital interruption of the portal vein and caudal vena cava in dogs: six case reports and a review of the literature. Vet Surg 1998; 27: 203-215. https://doi.org/10.1111/j.1532-950X.1998.tb00119.x
  13. Jones SM, Roh MS. Results of surgical resection for hepatocellular carcinoma. Cancer Treat Res 2001; 109: 59-75.
  14. Kosovsky JE, Manfra-Marretta S, Matthiesen DT, Patnaik AK. Results of partial hepatectomy in 18 dogs with hepatocellular carcinoma. J Am Anim Hosp Assoc. 1989; 25: 203-206.
  15. Liptak JM, Dernell WS, Monnet E, Powers BE, Bachand AM, Kenney JG, Withrow SJ. Massive hepatocellular carcinoma in dogs: 48 cases (1992–2002). J Am Vet Med Assoc 2004; 225: 1225-1230. https://doi.org/10.2460/javma.2004.225.1225
  16. Liptak JM, Dernell WS, Withrow SJ. Liver tumors in cats and dogs. Compend Contin Educ Pract Vet 2004; 26: 50-56.
  17. Lodi M, Chinosi S, Faverzani S, Ferro E. Clinical and ultrasonographic features of the canine hepatocellular carcinoma (CHC). Vet Res Commun 2001; 31: 293-295.
  18. Magne ML, Withrow SJ. Hepatic neoplasia. Vet Clin North Am Small Anim Pract 1985; 15: 243-256.
  19. Monto A, Wright TL. The epidemiology and prevention of hepatocellular carcinoma. Semin Oncol 2001; 28: 441-449. https://doi.org/10.1016/S0093-7754(01)90137-X
  20. Patnaik AK, Hurvitz AI, Lieberman PH. Canine hepatic neoplasms: a clinicopathological study. Vet Pathol 1980; 17: 553-564. https://doi.org/10.1177/030098588001700504
  21. Patnaik AK, Hurvitz AI, Lieberman PH, Johnson GF. Canine hepatocellular carcinoma. Vet Pathol 1981; 18: 427-438.
  22. Thamm DH. Hepatobiliary tumors. In: Withrow SJ, MacEwen EG, eds. Small Animal Clinical Oncology, 3rd ed. Philadelphia: WB Saunders. 2001: 327-334.
  23. Whiteley MB, Feeney DA, Whiteley LO, Hardy RM. Ultrasonographic appearance of primary and metastatic canine hepatic tumors. A review of 48 cases. J Ultrasound Med 1989; 8: 621-630.