Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지
DOI QR코드

DOI QR Code

Epithelial-mesenchymal transition in osteogenic sarcoma of the neck following oral squamous cell carcinoma

구강 편평세포암종 제거 후 발생한 경부 골육종에서의 상피간엽이행

  • Kim, Hyun-Sil (Departments of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University) ;
  • Kim, Nam-Hee (Departments of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University,) ;
  • Han, Seon-Hui (Departments of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University,) ;
  • Cha, In-Ho (Oral and Maxillofacial Surgery College of Dentistry, Yonsei University) ;
  • Seo, Dong-Jun (Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Park, Won-Se (Advanced General Dentistry, College of Dentistry, Yonsei University) ;
  • Yook, Jong-In (Departments of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University) ;
  • Kim, Hyung-Jun (Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
  • Received : 2010.03.18
  • Accepted : 2010.05.20
  • Published : 2010.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Postirradiation extraosseous osteogenic sarcomas are uncommon in the head and neck, despite the extensive use of high-dose radiation. It has been described as de novo radiation-induced neoplasm. We present a 73-year-old male who had been treated by radiotherapy for gingival cancer 7 years earlier and later developed extraosseous osteogenic sarcomas (EOSs) of the neck. Microscopically, the neck mass was composed with mesenchymal malignant cells with cartilaginous and osteogenic differentiation. Immunohistochemical stain demonstrated strong positivity of tumor cells for Snail, the one of major epithelial-mesenchymal transition (EMT) inducer. The E-cadherin expression was scarce, showing inverse relationship to Snail expression. Compared with previous squamous cell carcinoma (SCC) of the gingiva, the present EOS sample revealed the remained epithelial cells on cytokeratin immunohistochemistry, suggesting the tumor arise from the cells of epithelial origin. We have also reviewed the previous 6 cases of head and neck EOSs carefully. The clinicopathologic features of the unusual lesion suggest that it is an incomplete EMT of precedent epithelial malignancy rather than de novo pathology.

Keywords

References

  1. Lin SY, Chen WM, Wu HH, Chen WY, Chen TH. Extraosseous osteogenic sarcoma. J Chin Med Assoc 2005;68:542-5. https://doi.org/10.1016/S1726-4901(09)70091-7
  2. Rao U, Cheng A, Didolkar MS. Extraosseous osteogenic sarcoma: clinicopathological study of eight cases and review of literature. Cancer 1978;41:1488-96. https://doi.org/10.1002/1097-0142(197804)41:4<1488::AID-CNCR2820410437>3.0.CO;2-A
  3. Sordillo PP, Hajdu SI, Magill GB, Golbey RB. Extraosseous osteogenic sarcoma. A review of 48 patients. Cancer 1983;51:727- 34. https://doi.org/10.1002/1097-0142(19830215)51:4<727::AID-CNCR2820510429>3.0.CO;2-I
  4. Manning JT, Raymond AK, Batsakis JG. Extraosseous osteogenic sarcoma of the parotid gland. J Laryngol Otol 1986; 100:239-42. https://doi.org/10.1017/S0022215100099059
  5. Das Gupta TK, Hajdu SI, Foote FW Jr. Extraosseous osteogenic sarcoma. Ann Surg 1968;168:1011-22. https://doi.org/10.1097/00000658-196812000-00011
  6. Jussawalla DJ, Desai JG. Primary osteogenic sarcoma arising in extra-skeletal soft tissues of the neck. Br J Surg 1964;51:504-5. https://doi.org/10.1002/bjs.1800510709
  7. Parsons WH, Henthorne JC. Extraskeletal osteogenic sarcoma : report of a case of osteogenic sarcoma of the lip. Ann Surg 1944;119:595-601. https://doi.org/10.1097/00000658-194404000-00012
  8. Shanoff LB, Spira M, Hardy SB. Myositis ossificans: evolution to osteogenic sarcoma. Report of a histologically verified case. Am J Surg 1967;113:537-41. https://doi.org/10.1016/0002-9610(67)90203-6
  9. Yook JI, Li XY, Ota I, Fearon ER, Weiss SJ. Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 2005; 280:11740-8. https://doi.org/10.1074/jbc.M413878200
  10. Yook JI, Li XY, Ota I, Hu C, Kim HS, Kim NH, et al. A Wnt- Axin2-GSK3beta cascade regulates Snai11 activity in breast cancer cells. Nat Cell Biol 2006;8:1398-406. https://doi.org/10.1038/ncb1508
  11. Allan CJ, Soule EH. Osteogenic sarcoma of the somatic soft tissues. Clinicopathologic study of 26 cases and review of literature. Cancer 1971;27:1121-33. https://doi.org/10.1002/1097-0142(197105)27:5<1121::AID-CNCR2820270519>3.0.CO;2-3
  12. Kauffman SL, Stout AP. Extraskeletal osteogenic sarcomas and chondrosarcomas in children. Cancer 1963;16:432-9. https://doi.org/10.1002/1097-0142(196304)16:4<432::AID-CNCR2820160403>3.0.CO;2-E
  13. Wurlitzer F, Ayala L, Romsdahl M. Extraosseous osteogenic sarcoma. Arch Surg 1972;105:691-5. https://doi.org/10.1001/archsurg.1972.04180110016006
  14. Kalra S, Grimer RJ, Spooner D, Carter SR, Tillman RM, Abudu A. Radiation-induced sarcomas of bone: factors that affect outcome. J Bone Joint Surg Br 2007;89:808-13. https://doi.org/10.1302/0301-620X.89B6.18729
  15. Tan A, Ngan SY, Choong PF. Post-radiation sarcoma of the neck treated with re-irradiation followed by wide excision. World J Surg Oncol 2006;4:69. https://doi.org/10.1186/1477-7819-4-69
  16. Oda H, Tsukita S, Takeichi M. Dynamic behavior of the cadherin- based cell-cell adhesion system during Drosophila gastrulation. Dev Biol 1998;203:435-50. https://doi.org/10.1006/dbio.1998.9047
  17. Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007;7:415-28. https://doi.org/10.1038/nrc2131
  18. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-54. https://doi.org/10.1038/nrc822
  19. Becker KF, Rosivatz E, Blechschmidt K, Kremmer E, Sarbia M, Ho ¨fler H. Analysis of the E-cadherin repressor Snail in primary human cancers. Cells Tissues Organs 2007;185:204-12. https://doi.org/10.1159/000101321
  20. Francl C, Takkunen M, Dave N, Alameda F, Gomez S, Rodrlguez R, et al. Expression of Snail protein in tumor-stroma interface. Oncogene 2006;25:5134-44. https://doi.org/10.1038/sj.onc.1209519
  21. Fine G, Stout AP. Osteogenic sarcoma of the extraskeletal soft tissues. Cancer 1956;9:1027-43. https://doi.org/10.1002/1097-0142(195609/10)9:5<1027::AID-CNCR2820090522>3.0.CO;2-K
  22. Brabletz T, Hlubek F, Spaderna S, Schmalhofer O, Hiendlmeyer E, Jung A, et al. Invasion and metastasis in colorectal cancer: epithelial- mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs 2005;179: 56-65. https://doi.org/10.1159/000084509
  23. Jeschke U, Mylonas I, Kuhn C, Shabani N, Kunert-Keil C, Schindlbeck C, et al. Expression of E-cadherin in human ductal breast cancer carcinoma in situ, invasive carcinomas, their lymph node metastases, their distant metastases, carcinomas with recurrence and in recurrence. Anticancer Res 2007;27:1969-74.
  24. Liu J, Ikeguchi M, Nakamura S, Kaibara N. Re-expression of the cadherin-catenin complex in lymph nodes with metastasis in advanced gastric cancer: the relationship with patient survival. J Exp Clin Cancer Res 2002;21:65-71.
  25. Park D, Karesen R, Axcrona U, Noren T, Sauer T. Expression pattern of adhesion molecules (E-cadherin, alpha-, beta-, gammacatenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis. APMIS 2007;115:52-65. https://doi.org/10.1111/j.1600-0463.2007.apm_524.x

Cited by

  1. Extraskeletal osteosarcoma: nosologocal diversity, morphology, differential diagnosis, and features of metastasis vol.80, pp.3, 2010, https://doi.org/10.17116/patol201880359-65