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Atherogenic Risk Stratification According to Changes in the Geometrical Shape of the Coronary Artery

관상동맥의 기하학적 형상변화에 따른 동맥경화 위험도

  • Suh, Sang-Ho (Dept. of Mechanical Engineering, Soongsil Univ.) ;
  • Park, Jun-Gil (Dept. of Mechanical Engineering, Soongsil Univ.) ;
  • Roh, Hyung-Woon (IVAI GD3) ;
  • Lee, Byung-Kwon (Cardiology Division, Dept. of Internal Medicine Gangnam Severance Hospital, Yonsei Univ.) ;
  • Kwon, Hyuck-Moon (Cardiology Division, Dept. of Internal Medicine Gangnam Severance Hospital, Yonsei Univ.)
  • 서상호 (숭실대학교 기계공학과) ;
  • 박준길 (숭실대학교 기계공학과) ;
  • 노형운 ((주)아이베이디지쓰리) ;
  • 이병권 (연세대학교 강남세브란스병원 심장내과) ;
  • 권혁문 (연세대학교 강남세브란스병원 심장내과)
  • Received : 2009.10.30
  • Accepted : 2010.08.24
  • Published : 2010.10.01

Abstract

A previous study showed that hemodynamics is correlated with stenosis in the coronary artery. The flow characteristics and the distributions of the hemodynamic wall parameters in the coronary artery are investigated under physiological flow condition. The present study also aims to establish the mechanism of the generation of atherosclerosis by analyzing the hemodynamic variables in the coronary artery where atherosclerosis frequently occurs. The stenosis phenomena due to atherosclerosis are related to not only the biochemical reaction between blood and blood vessels but also the hemodynamic factors sush as flow separation and oscillatory wall shear stress. As the bifurcated angle increases, the size of the recirculation area that appears in the cross section increases and disturbed flow is observed in this area. We speculate that this area is the starting point of atherosclerosis in the coronary artery.

박동유동조건에서 관상동맥 내의 유동특성과 혈류역학적 인자 분포를 선행연구에서 수행하여 혈류역학이 관상동맥 내의 협착현상과 연관관계가 있음을 밝혔다. 동맥경화증의 호발부위인 관상동맥 분지부에서 혈류역학적 변수를 분석하여 동맥경화증의 발생기전을 규명하는 것이 본 연구의 목적이다. 동맥경화증에 의한 협착현상은 혈액과 혈관벽 사이의 생화학 반응뿐 아니라 유동박리나 벽전단응력과 같은 혈류역학적 인자와도 관계 있음을 확인하였다. 관상동맥 분지부의 분지각이 증가할수록 분지부 단면에서의 재순환영역의 크기가 증가하고 교란유동이 발생하게 된다. 이 재순환영역이 관상동맥에서 동맥경화의 시작점으로 의심되는 영역이라 할 수 있다.

Keywords

References

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