Acknowledgement
Supported by : National Research Foundation of Korea (NRF)
References
- Chvatal A, Anderova M, Neprasova H, Prajerova I, Benesova J, Butenko O, Verkhratsky A. Pathological potential of astroglia. Physiol Res. 2008;57 Suppl 3:S101-110.
- Rodriguez JJ, Olabarria M, Chvatal A, Verkhratsky A. Astroglia in dementia and Alzheimer's disease. Cell Death Differ. 2009;16:378-385. https://doi.org/10.1038/cdd.2008.172
- Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 1999;20:649-688. https://doi.org/10.1210/er.20.5.649
- Michalik L, Desvergne B, Wahli W. Peroxisome-proliferatoractivated receptors and cancers: complex stories. Nat Rev Cancer. 2004;4:61-70. https://doi.org/10.1038/nrc1254
- Lalloyer F, Staels B. Fibrates, glitazones, and peroxisome proliferator-activated receptors. Arterioscler Thromb Vasc Biol. 2010;30:894-899. https://doi.org/10.1161/ATVBAHA.108.179689
- Heneka MT, Landreth GE. PPARs in the brain. Biochim Biophys Acta. 2007;1771:1031-1045. https://doi.org/10.1016/j.bbalip.2007.04.016
- Pannu R, Singh AK, Singh I. A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma. J Biol Chem. 2005;280:13742-13751. https://doi.org/10.1074/jbc.M411959200
- Gao Q, Li Y, Shen L, Zhang J, Zheng X, Qu R, Liu Z, Chopp M. Bone marrow stromal cells reduce ischemia-induced astrocytic activation in vitro. Neuroscience. 2008;152:646-655. https://doi.org/10.1016/j.neuroscience.2007.10.069
- Selmaj KW, Farooq M, Norton WT, Raine CS, Brosnan CF. Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J Immunol. 1990;144:129-135.
- Forman BM, Chen J, Evans RM. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A. 1997;94:4312-4317. https://doi.org/10.1073/pnas.94.9.4312
- Xu J, Drew PD. Peroxisome proliferator-activated receptorgamma agonists suppress the production of IL-12 family cytokines by activated glia. J Immunol. 2007;178:1904-1913. https://doi.org/10.4049/jimmunol.178.3.1904
- Sun GJ, Xie XM, Xing Y, Yan WH, Yang TL, Yu GL. Effects of fenofibrate on the proliferation and apoptosis and nitric oxide synthase expression of cultured human umbilical vein endothelial cells induced by lysophosphatidylcholine. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006;31:373-378.
- Gizard F, Amant C, Barbier O, Bellosta S, Robillard R, Percevault F, Sevestre H, Krimpenfort P, Corsini A, Rochette J, Glineur C, Fruchart JC, Torpier G, Staels B. PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a. J Clin Invest. 2005;115:3228-3238. https://doi.org/10.1172/JCI22756
- Perez-Ortiz JM, Tranque P, Vaquero CF, Domingo B, Molina F, Calvo S, Jordan J, Cena V, Llopis J. Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma. J Biol Chem. 2004;279:8976-8985. https://doi.org/10.1074/jbc.M308518200
- Ogata T, Miyauchi T, Irukayama-Tomobe Y, Takanashi M, Goto K, Yamaguchi I. The peroxisome proliferator-activated receptor alpha activator fenofibrate inhibits endothelin-1-induced cardiac fibroblast proliferation. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S279-282. https://doi.org/10.1097/01.fjc.0000166274.24797.0e
- Pogue AI, Cui JG, Li YY, Zhao Y, Culicchia F, Lukiw WJ. Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation. Neurosci Lett. 2010;476:18-22. https://doi.org/10.1016/j.neulet.2010.03.054
- Quintana A, Molinero A, Borup R, Nielsen FC, Campbell IL, Penkowa M, Hidalgo J. Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome. Dev Neurobiol. 2008;68:195-208. https://doi.org/10.1002/dneu.20584
- Cardenas H, Bolin LM. Compromised reactive microgliosis in MPTP-lesioned IL-6 KO mice. Brain Res. 2003;985:89-97. https://doi.org/10.1016/S0006-8993(03)03172-X
- Penkowa M, Giralt M, Carrasco J, Hadberg H, Hidalgo J. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia. 2000;32:271-285. https://doi.org/10.1002/1098-1136(200012)32:3<271::AID-GLIA70>3.0.CO;2-5
- Xu J, Chavis JA, Racke MK, Drew PD. Peroxisome proliferator-activated receptor-alpha and retinoid X receptor agonists inhibit inflammatory responses of astrocytes. J Neuroimmunol. 2006;176:95-105. https://doi.org/10.1016/j.jneuroim.2006.04.019
Cited by
- Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system vol.89, pp.5, 2011, https://doi.org/10.1016/j.lfs.2011.05.011
- Fenofibrate in cancer: mechanisms involved in anticancer activity vol.4, pp.None, 2010, https://doi.org/10.12688/f1000research.6153.2
- Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin vol.58, pp.None, 2016, https://doi.org/10.1016/j.bbi.2016.01.001